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|Janet was born in Beijing, China and grew up in Fremont,
CA. She received her B.S. degree from UC Davis, where she
majored in Biological Sciences with an emphasis in Medical
Microbiology. Janetís interest in microbiology and
host-pathogen interaction brought her to UC Irvine, where
she conducted her graduate studies in the lab of Dr. Manuela
In the Raffatellu lab Janet studied the role of zinc acquisition in Salmonella Typhimurium pathogenesis. She demonstrated that S. Typhimurium is resistant to calprotectin: an antimicrobial protein that binds to and sequesters zinc ion from microbes, and is highly expressed during S. Typhimurium gastroenteritis. S. Typhimurium is able to overcome calprotectin-mediated zinc withholding by expressing a high affinity zinc transporter, ZnuABC, thereby promoting its own growth over competing microbes. During her graduate studies Janet was supported by the NIH Immunology Research Training Program grant, and the American Heart Association Predoctoral Fellowship grant.
As a postdoc in the Nizet lab, Janetís project focuses on how the cyclic AMP activating cholera toxin and anthrax edema factor interfere with Rab11-mediated protein trafficking and host cell barrier and immune functions. This research is conducted in collaboration with the laboratory of Ethan Bier in the UCSD Division of Biological Sciences.