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Manuscripts Now Accepted or In Press

Cell Host &
                Microbe Yang WH, Heithoff DM, Aziz P, Haslund-Gourney B, Westman JS, Narisawa S, Pinkerton AB, Millan JL, Nizet V, Mahan MJ, Marth JD.  Accelerated aging and clearance of anti-inflammatory enzymes in the pathophysiology of Gram-negative sepsis and its therapeutic reversal. Cell Host Microbe 2018
Nature Communications Kavvas E, Catoiu E, Mih N, Yurkovich J, Seif Y, Dillon N, Heckmann D, Anand A, Yang L, Nizet V, Monk J, Palsson BO. Machine learning and structural analysis of Mycobacterium tuberculosis pan-genome identifies genetic signatures of antibiotic resistance.  Nat Commun 2018
PNAS Fong J, Tsai CM, Nizet V, Varki A, Bui J.  Siglec-7 Engagement by GBS β-protein suppresses pyroptotic cell death of natural killer cells.  Proc Natl Acad Sci USA 2018
Journal of Innate Immunity Riestra AM, Valderrama JA, Patras KA, Booth SD, Quek X, Tsai CM.  Trichomonas vaginalis induces NLRP3 inflammasome activation  and pyroptosis in human macrophages.  J Innate Immun 2018
PLoS Pathogens van Hensbergen VP, Movert E, de Maat V, Le Breton Y, Lambeau G, Payre C, Kahn F, Henningham A, Nizet V, Van Strijp JA, Carlsson F, McIver KS,  van Sorge NM. Streptococcal Lancefield polysaccharides are critical cell wall determinants for human group IIA secreted phospholipase A2 to exert its bactericidal effects.  PLoS Pathogens 2018


Submitted Manuscripts in Peer Review



Munguia J, Lin L, Olson J, Nonejuie P, Gallo RL, Adams MD, Kirkup BC, Pogliano J, Zurawski DV, Nizet V. Outer membrane lipid modifying protein VacJ contributes to antimicrobial peptide resistance and virulence of multidrug-resistant Acinetobacter baumannii.

Pence MA, Malone C, van Sorge NM, Horswill AR, Nizet V.  The metalloprotease aureolysin is not essential for cathelicidin resistance or virulence of methicillin-resistant Staphylococcus aureus

Caffrey AR, Timbrook TT, Ali SR, Nizet V, Sakoulas G.  Proton pump inhibitors do not influence clinical outcomes in patients with Staphylococcus aureus bacteremia.

Pashangeh S, Shekarforoush SS, Aminlari M, Hosseinzadeh S, Nizet V, Dahesh S, Rahmdel S.  Molecular characteristics of histamine producing and degrading staphylococci isolated from goats and sheep milk.

Henningham A, Davies MR, Chan A, Thompson LF, Stewart C, Buffalo CZ, Corriden R, McIntyre L, Olson J, Ghosh P, Boss GR, Walker MJ, Cole JN, Nizet V. The conserved surface-associated 5′-nucleotidase of group A Streptococcus is a vaccine antigen that protects against systemic infection.

Sun J, LaRock DL, Kimmey JM, Olson J, Jiang Z, O’Donoghue AJ, Nizet V, LaRock CN. Pseudomonas aeruginosa proteolytic activation of IL-1β drives pathological inflammation

Sakoulas G, Murray B, Askarian F, Nizet V. Ertapenem and cefazolin synergism in methicillin-susceptible Staphylococcus aureus with type A beta-lactamase.

LaRock DL, Ettouati E, Richard M, Bushway PJ, Adler ED, Nizet V, LaRock CN.  Inflammasome inhibition protects against cardiac glycoside cellular toxicity.

Corriden R, Döhrmann S, Flores R, Denholtz M, Catteau L, Olson J, Chen A, Carlin AF, Nizet V.   Free fatty acids enhance formation of neutrophil extracellular traps.

Dan JM, Dr. Colin Havenar-Daughton C, Kendric K, Kaushik K, Rosales S, Anderson E, LaRock C, Pandurangan V, Seumois G,  Layfield D, Cutress R, Ottensmeier C, Lindestam Alrehman C, Sette A, Nizet V, Bothwell M, Brigger M, Crotty S. Recurrent tonsillitis is a genetic immunosusceptibility disease associated with poor antibody responses and aberrant T follicular helper cells.

Vrbanac A, Riestra A, Coady A, Knight R, Nizet V, Patras KA. The murine vaginal microbiota and perturbation by the human pathogen group B Streptococcus.

Geriak M, Haddad F, Rizvi K, Rose W, LaPlante K, Yu M, Vasina L, Ouellette K, Zervos M, Nizet V, Sakoulas G. A pilot randomized trial comparing ceftaroline plus daptomycin to standard of care monotherapy in patients with methicillin-resistant Staphylococcus aureus bacteremia.

Rivera-Hernandez T, Carnathan D, Jones S, Cork A, Davies M, Moyle P, Toth I, Batzloff M, McCarthy J, Nizet V, Goldblatt D, Silvestri G, Walker MJ. An experimental group A Streptococcus vaccine that reduces pharyngitis and tonsillitis in a non-human primate model.

Uchiyama S, Sun J, Fukahori K, Wu M, Schwarz F, Siddiqui SS, Varki A, Marth JD, Nizet V.  Dual actions of group B Streptococcus capsular sialic acid provide resistance to platelet-mediated antimicrobial killing.

Cohen-Katsenelson K, Stender JD, Uchiyama S, Grezchnik AT, Nizet V, Glass CK, Newton AC. PH domain leucine rich repeat protein phosphatase 1 (PHLPP1) counter-regulates STAT1-mediated inflammatory signaling.

Zhang Q, Chao TC, Patil VS, Qin Y, Kant Tiwari S, Chiou J, Dobin A, Tsai CM, Li Z, Dang J, Gupta S, Urdahl K, Nizet V, Gingeras TR, Gaulton K, Rana TM.  A cis-acting long noncoding RNA ROCKI regulates inflammatory gene expression.

Meier A, Nizet V. The impact of anesthetics on human neutrophil function.

Quinn RA, Vrbanac A, Melnik AV, Patras KA, Christy M, Nelson AT, Aksenov A, Tripathi A, Humphrey G, da Silva R, Bussell R, Thron T, Wang M, Vargas F, Gauglitz JM, Meehan MJ, Poulsen O, Boland BS, Chang HT, Sandborn WJ, Lim M, Garg N, Lumeng J, Kazmierczak BI, Jain R, Egan M, Rhee KE, Haddad GG, Siegel D, Mazmanian S, Nizet V, Knight R, Dorrestein PC. Chemical impacts of the microbiome across scales reveal novel conjugated bile acids.

Meier A, Chien J, Hobohm L, Patras KA, Nizet V, Corriden R. Propofol significantly decreases neutrophil extracellular trap (NET) production in fresh human neutrophils.

Uchiyama S, Dahesh S, Nizet V, Kessler J. Enhanced topical delivery of non-complexed molecular iodine for methicillin-resistant Staphylococcus aureus decolonization.

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