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Manuscripts Now Accepted or In Press

Cell Wozniak JM, Mills RH, Olson J, Caldera JR, Poore GD, Carrillo-Terrazas M, Tsai CM, Vargas F, Knight R, Dorrestein PC, Liu GY, Nizet V, Sakoulas G, Rose W, Gonzalez DJ. Mortality risk profiling of Staphylococcus aureus bacteremia by multi-omic serum analysis reveals early predictive and pathogenic molecular signatures.  Cell 2020
EBiomedicine Sun J, LaRock DL, Skowronski E, Kimmey JM, Olson J, Jiang Z, O’Donoghue AJ, Nizet V, LaRock CN. Role of inflammasome-independent activation of IL-1β by the Pseudomonas aeruginosa protease LasB.  BioRxiv
mSystems Campeau A, Mills R, Blanchette M, Bajc K, Malfavon M, Munji R, Deng L, Hancock B, Patras K, Olson J, Nizet V, Daneman R, Doran K, and Gonzalez D.  Multi-dimensional proteome profiling of blood-brain barrier perturbation by group B Streptococcus.


Submitted Manuscripts in Peer Review



Munguia J, Lin L, Olson J, Nonejuie P, Gallo RL, Adams MD, Kirkup BC, Pogliano J, Zurawski DV, Nizet V. Outer membrane lipid modifying protein VacJ contributes to antimicrobial peptide resistance and virulence of multidrug-resistant Acinetobacter baumannii.

Pence MA, Malone C, van Sorge NM, Horswill AR, Nizet V.  The metalloprotease aureolysin is not essential for cathelicidin resistance or virulence of methicillin-resistant Staphylococcus aureus

Pashangeh S, Shekarforoush SS, Aminlari M, Hosseinzadeh S, Nizet V, Dahesh S, Rahmdel S.  Molecular characteristics of histamine producing and degrading staphylococci isolated from goats and sheep milk.

Henningham A, Davies MR, Chan A, Thompson LF, Stewart C, Buffalo CZ, Corriden R, McIntyre L, Olson J, Ghosh P, Boss GR, Walker MJ, Cole JN, Nizet V. The conserved surface-associated 5′-nucleotidase of group A Streptococcus is a vaccine antigen that protects against systemic infection.

Sakoulas G, Murray B, Askarian F, Nizet V. Ertapenem and cefazolin synergism in methicillin-susceptible Staphylococcus aureus with type A beta-lactamase.

Corriden R, Döhrmann S, Flores R, Denholtz M, Catteau L, Olson J, Chen A, Carlin AF, Nizet V.   Free fatty acids enhance formation of neutrophil extracellular traps.

Escajadillo T, Popov LM, Dahesh S, Carette JE, Nizet V. Sterol regulatory element binding protein-2 (SREBP-2) influences host cell susceptibility to the bacterial pore-forming toxin streptolysin O.

Sun J, Uchiyama S, Olson J, Cornax I, Ando N, Kohno Y, Kyaw M, Aguilar B, Haste NM, Rose WE, Sakoulas G, Marth JD, Nizet V.  Repurposed drugs block toxin-driven platelet clearance by the hepatic Ashwell-Morell receptor to clear Staphylococcus aureus bacteremia.

Washington A, Varki N, Valderrama JA, Nizet V, Bui JD. Evaluation of interleukin-17D in host immunity to group A Streptococcus infection.

Mesci P, LaRock C, Jeziorski J, Trujillo C, Nizet V, Muotri AR. MeCP2 is essential for optimal human microglia function.

Brouwer S, Barnett TC, Ly D, Kasper KJ, De Oliveira DM, Rivera-Hernandez T, Cork AJ, McIntyre L, Jespersen MG, Richter J, Schulz BL, Dougan G, Nizet V, Yuen KY, You Y, McCormick JK, Sanderson-Smith ML, Davies MR, Walker MJ. Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes. BioRxiv

Rada C, Mejia-Pena H, Grimsey N, Canto Cordova I, Olson J, Wozniak J, Gonzalez DJ, Nizet V, Trejo J. Heat Shock Protein 27 activity is linked to endothelial barrier resolution induced by GPCR pro-inflammatory mediators.

Saha S, Coady A, Sasmal A, Kawanishi K, Choudhury B, Yu H, Sorensen R, Inostroza J, Schoenhofen I, Chen X, Münster-Kühnel A, Sato C, Kitajima K, Ram S, Nizet V, Varki A. Ketodeoxynonulosonic acid uptake and surface display by non-typeable Haemophilus influenzae: impairment of bacterial immune evasion and implications for therapeutics.

Vrbanac A, Patras KA, Jarmusch AK, Mills RH, Shing S, Quinn RA, Vargas F, Gonzalez DJ, Dorrestein PC, Knight R, Nizet V. Evaluating organism-wide changes in the metabolome and microbiome following a single dose of antibiotic.

Askarian F, Uchiyama S, Masson H, Bunaes AC, Golten O, Mekasha S, Røhr ÅK, Kommedal E, Ludviksen JA, Sørenson HV, Arntzen MØ, Schmidt B, van Sorge NM, Eijsink VG, Krengel U, Mollnes TE, Lewis NE, Nizet V, Vaaje-Kolstad G. The lytic polysaccharide monooxygenase CbpD promotes Pseudomonas aeruginosa virulence in systemic infection.

Liu X, Kimmey JM, de Bakker V, Nizet V, Veening JW. Exploration of bacterial bottlenecks and Streptococcus pneumoniae pathogenesis by CRISPRi-seq.  BioRxiv

Machado H, Seif Y, Sakoulas G, Olson CA, Szubin R, Palsson BO, Nizet V, Feist AM. Environmental conditions dictate differential evolution of vancomycin resistance in Staphylococcus aureus.

Kumaraswamy M, Coady A, Szubin R, Martin TC, Palsson BO, Nizet V, Monk JM. Comprehensive whole genome sequencing with hybrid assembly of a multi-drug resistant Candida albicans isolate causing cerebral abscess

Seif Y, Poudel S, Tsunemoto H, Rajput A, Szubin R, Meehan MJ, Olson CA, Alarcon G, Lamsa A, Dillon N, Vrbananc A, Sugie J, Dahesh S, Monk JM, Dorrestein PC, Knight R, Pogliano J, Feist AM, Palsson BO, Nizet V. Profiling the effect of nafcillin on HA-MRSA D592 using bacteriological and physiological media.  BioRxiv

Sastry AV, Dillon N, Poudel S, Hefner Y, Xu S, Szubin R, Feist A, Nizet V, Palsson BO. Decomposition of transcriptional responses provides insights into differential antibiotic susceptibility.  BioRxiv

Machado H, Seif Y, Sakoulas G, Olson CA, Szubin R, Palsson BO, Nizet V, Adam M, Feist A. Environmental conditions dictate differential evolution of vancomycin resistance in Staphylococcus aureus.

Rajput A, Poudel S, Tsunemoto H, Meehan M, Szubin R, Olson CA, Seif Y, Lamsa A, Dillon N, Vrbanac A, Sugie J, Dahesh S, Monk JM, Dorrestein PC, Knight R, Pogliano P, Nizet V, Feist AM, Palsson BO. Identifying the effect of vancomycin on HA-MRSA strains using bacteriological and physiological media. BioRxiv

Swanson S, Katkar G, Tam J, Pranadinata R, Chareddy Y, Coates J, Olson J, Nizet V, Kufareva I, Das S, Castillo V, Ghosh P. GIV dampens macrophage inflammatory responses by inhibiting TLR4 signaling.

Dillon N, Seif Y, Tsunemoto H,  Poudel S, Meehan MJ,  Szubin R, Olson CA, Rajput A, Alarcon G, Lamsa A, Vrbanac A, Sugie J, Dahesh S, Monk JM, Dorrestein PC, Knight R, Feist AM, Pogliano P, Palsson BO, Nizet V. Characterizing the response of Acinetobacter baumannii ATCC 17978 to azithromycin in multiple in vitro growth conditions.  BioRxiv

Bjanes E, Nizet V. Backhanding complement: pathogen resistance to a cascading host defense system.

Hirose Y, Yamaguchi M, Sumitomo T, Nakata M, Hanada T, Okuzaki D, Motooka D, Mori Y, Kawasaki H, Amagai M, Nizet V, Kawabata S. Streptococcus pyogenes upregulates arginine metabolism to exert its pathogenesis on the skin surface.

Kim JK, Uchiyama S, Gong H, Zhang L, Nizet V. Engineered Biomimetic Platelet membrane-coated nanoparticles block Staphylococcus aureus cytotoxicity and protect against lethal systemic infection.

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