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Manuscripts Now Accepted or In Press

mSystems Hirose Y, Poudel S, Sastry A, Rychel K, Zielinski D, Lim H, Menon N, Bergsten H, Uchiyama SA, Hanada T, Kawabata S, Palsson BO,  Nizet V. Elucidation of independently modulated genes in Streptococcus pyogenes reveals carbon sources that control its expression of hemolytic toxins. mSystems 2023 (in press)   BioRxiv
Nature Immunology Mohanty T, Karlsson CAQ, Chao Y, Malmström E, Bratanis E, Grentzmann A, Mørch M, Nizet N, Malmström L, Linder A, Shannon O, Malmström J, A pharmacoproteomic landscape of organotypic intervention responses in Gram-negative sepsis. Nat Comm 2023 (in press)
Cambridge Prisms: Precision
                Medicine Baglaenko Y, Wagner C, Bhoj V, Brodin P, Gershwin E, Graham D, Invernizzi P, Kidd K, Kuronsky I, Levy M, Mammen A, Nizet V, Ramirez-Valle F, Sites E, Williams M, Wilson M, Rose N, Ladd V, Sirota M.Making inroads to precision medicine for the treatment of autoimmune diseases: harnessing genomic studies to better diagnose and treat complex disorders. Cambridge Prisms: Precis Med 2023 (in press)


Submitted Manuscripts in Peer Review



Askarian F, Tsai CM, Cordarab G, Zurich RH, Bjånes E, Goltenc O, Sørensen HV, Kousha A, Meier A, Chikwatie E, Bruun JA, Ludviksen JA, Choudhury B, Trieu D, Davis S, Edvardsen PKT, Mollnes TE, Liu GY, Krengel U, Conrad DJ, Vaaje-Kolstad G, Nizet V.  Immunization with lytic polysaccharide monooxygenase CbpD induces protective immunity against lethal Pseudomonas aeruginosa pneumonia

Kumaraswamy M, Riestra A, Flores A, Uchiyama S, Dahesh S, Bondsäter G, Nilsson V, Chang M, Seo H, Sakoulas G, Nizet V. Unrecognized Potent Activities of Colistin Against Clinically Important mcr + Enterobacteriaceae Revealed in Synergy with Host Immunity. bioRxiv [Preprint]. 2023 Mar 21:2023.03.21.533661.

Munguia J, Menon N, Lin L, Olson J, Nonejuie P, Gallo RL, Adams MD, Kirkup BC, Pogliano J, Zurawski DV, Nizet V. Outer membrane lipid modifying protein VacJ contributes to antimicrobial peptide resistance and virulence of multidrug-resistant Acinetobacter baumannii.

Pence MA, Malone C, van Sorge NM, Horswill AR, Nizet V. The metalloprotease aureolysin is not essential for cathelicidin resistance or virulence of methicillin-resistant Staphylococcus aureus

Henningham A, Davies MR, Chan A, Thompson LF, Stewart C, Buffalo CZ, Corriden R, McIntyre L, Olson J, Ghosh P, Boss GR, Walker MJ, Cole JN, Nizet V. The conserved surface-associated 5′-nucleotidase of group A Streptococcus is a vaccine antigen that protects against systemic infection.

Corriden R, Döhrmann S, Flores R, Denholtz M, Catteau L, Olson J, Chen A, Carlin AF, Nizet V.   Free fatty acids enhance formation of neutrophil extracellular traps.

Escajadillo T, Popov LM, Dahesh S, Carette JE, Nizet V. Sterol regulatory element binding protein-2 (SREBP-2) influences host cell susceptibility to the bacterial pore-forming toxin streptolysin O.

Mesci P, LaRock CN, Ferrasa A, Herai RH, Jeziorski J, Saleh A, Trujillo CA, Nizet V, Muotri AR. Impact of human microglial cells on neuronal connectivity during development.

Dillon N, Seif Y, Tsunemoto H,  Poudel S, Meehan MJ,  Szubin R, Olson CA, Rajput A, Alarcon G, Lamsa A, Vrbanac A, Sugie J, Dahesh S, Monk JM, Dorrestein PC, Knight R, Feist AM, Pogliano P, Palsson BO, Nizet V. Characterizing the response of Acinetobacter baumannii ATCC 17978 to azithromycin in multiple in vitro growth conditions.  BioRxiv

Perez-Lopez A, Silva S, Dillon NA, Brandt S, Gerner R, Lee M, Melchior K, Torres-Ruiz J, Sosa-Hernandez V, Cervantez-Diaz R, Perez-Fragoso A, Romer-Ramirez S, Gomez-Martin, D, Maravillas-Montero, J, Nuccio SP, Nizet V, Raffatellu M. CCL28 modulates neutrophil responses and impacts the trajectory of mucosal infections.

Ghebremedhin A, Shepard RM, Betts C, Robinson S, Chen H, Paradise M, Hu J, Sasik S, Fisch KM, Zak J, Uchiyama S, Seo H, Paradise M, Dayao DA, Tzipori S, Piedra-Mora C, Das S, Hasteh F, Russo H, Sun X, Xu L, Kirchberger NC, Chin SM, Von Schalscha T, Cheresh D, Morrey JD, Alargova R, O'Connell B, Martinot TA, Patel SP, Nizet V, Martinot AJ, Coussens LM, Varner JA. PI3Kg inhibition circumvents inflammation and 1 lethality in SARS-CoV-2 and other infections.

Wang KC, Nizet V, Ghosh P. Design of M protein immunogens to elicit broadly reactive antibodies against Streptococcus pyogenes. BioRxiv

Zhang Y, Bharahthi V, Dokoshi T, de Anda J, Tumey Ursery L, Kulkarni NN, Chen J, Luo EWC, Wang L, Xu H, Coady A, Zurich R, Lee MW, Matsui T, Lee HK, Chan LC, Schepmoes AA, Lipton MS, Zhao R, Adkins JN, Clair G, Thurlow LR, Schisler J, Wolfgang MC, Hagan RS, Yeaman MR, Weiss TM, Chen X, Li MMH, Nizet V, Antoniak S, Mackman N, Gallo RL, Wong GCL. Viral afterlife: SARS-CoV-2 as a reservoir of immunomimetic peptides that re-assemble into pro-inflammatory supramolecular complexes.

X Liu, Van Maele L, Matarazzo L, Soulard DS, Duarte da Silva VA, de Bakker V, Dénéréaz J, Bock FP, Taschner M, Gruber S, Nizet V, Sirard JC, Veening JW. A conserved antigen induces respiratory Th17-mediated serotype-independent protection against pneumococcal superinfection.

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