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Manuscripts Now Accepted or In Press

Science Translational Medicine Dan JM, Havenar-Daughton C, Kendric K, Kaushik K, Rosales S, Anderson E, LaRock C, Pandurangan V, Seumois G,  Layfield D, Cutress R, Ottensmeier C, Lindestam Alrehman C, Sette A, Nizet V, Bothwell M, Brigger M, Crotty S. Recurrent tonsillitis is a genetic immunosusceptibility disease associated with poor antibody responses and aberrant T follicular helper cells.  Sci Transl Med 2019
Chemical Biology & Drug
                Design Huang YM, Munguia J, Miao Y, Nizet V., McCammon JA. Docking simulation and antibiotic discovery targeting the MlaC protein in Gram-negative bacteria.  Chem Biol Drug Des 2019


Submitted Manuscripts in Peer Review



Munguia J, Lin L, Olson J, Nonejuie P, Gallo RL, Adams MD, Kirkup BC, Pogliano J, Zurawski DV, Nizet V. Outer membrane lipid modifying protein VacJ contributes to antimicrobial peptide resistance and virulence of multidrug-resistant Acinetobacter baumannii.

Pence MA, Malone C, van Sorge NM, Horswill AR, Nizet V.  The metalloprotease aureolysin is not essential for cathelicidin resistance or virulence of methicillin-resistant Staphylococcus aureus

Caffrey AR, Timbrook TT, Ali SR, Nizet V, Sakoulas G.  Proton pump inhibitors do not influence clinical outcomes in patients with Staphylococcus aureus bacteremia.

Pashangeh S, Shekarforoush SS, Aminlari M, Hosseinzadeh S, Nizet V, Dahesh S, Rahmdel S.  Molecular characteristics of histamine producing and degrading staphylococci isolated from goats and sheep milk.

Henningham A, Davies MR, Chan A, Thompson LF, Stewart C, Buffalo CZ, Corriden R, McIntyre L, Olson J, Ghosh P, Boss GR, Walker MJ, Cole JN, Nizet V. The conserved surface-associated 5′-nucleotidase of group A Streptococcus is a vaccine antigen that protects against systemic infection.

Sun J, LaRock DL, Kimmey JM, Olson J, Jiang Z, O’Donoghue AJ, Nizet V, LaRock CN. Pseudomonas aeruginosa proteolytic activation of IL-1β drives pathological inflammation

Sakoulas G, Murray B, Askarian F, Nizet V. Ertapenem and cefazolin synergism in methicillin-susceptible Staphylococcus aureus with type A beta-lactamase.

LaRock DL, Ettouati E, Richard M, Bushway PJ, Adler ED, Nizet V, LaRock CN.  Inflammasome inhibition protects against cardiac glycoside cellular toxicity.

Corriden R, Döhrmann S, Flores R, Denholtz M, Catteau L, Olson J, Chen A, Carlin AF, Nizet V.   Free fatty acids enhance formation of neutrophil extracellular traps.

Geriak M, Haddad F, Rizvi K, Rose W, LaPlante K, Yu M, Vasina L, Ouellette K, Zervos M, Nizet V, Sakoulas G. Clinical data on daptomycin plus ceftaroline versus standard of care monotherapy in the treatment of methicillin-resistant Staphylococcus aureus bacteremia.

Rivera-Hernandez T, Carnathan D, Jones S, Cork A, Davies M, Moyle P, Toth I, Batzloff M, McCarthy J, Nizet V, Goldblatt D, Silvestri G, Walker MJ. An experimental group A Streptococcus vaccine that reduces pharyngitis and tonsillitis in a non-human primate model.

Uchiyama S, Sun J, Fukahori K, Wu M, Schwarz F, Siddiqui SS, Varki A, Marth JD, Nizet V.  Dual actions of group B Streptococcus capsular sialic acid provide resistance to platelet-mediated antimicrobial killing.

Cohen-Katsenelson K, Stender JD, Uchiyama S, Grezchnik AT, Nizet V, Glass CK, Newton AC. PH domain leucine rich repeat protein phosphatase 1 (PHLPP1) counter-regulates STAT1-mediated inflammatory signaling.

Zhang Q, Chao TC, Patil VS, Qin Y, Kant Tiwari S, Chiou J, Dobin A, Tsai CM, Li Z, Dang J, Gupta S, Urdahl K, Nizet V, Gingeras TR, Gaulton K, Rana TM.  A cis-acting long noncoding RNA ROCKI regulates inflammatory gene expression.

Quinn RA, Vrbanac A, Melnik AV, Patras KA, Christy M, Nelson AT, Aksenov A, Tripathi A, Humphrey G, da Silva R, Bussell R, Thron T, Wang M, Vargas F, Gauglitz JM, Meehan MJ, Poulsen O, Boland BS, Chang HT, Sandborn WJ, Lim M, Garg N, Lumeng J, Kazmierczak BI, Jain R, Egan M, Rhee KE, Haddad GG, Siegel D, Mazmanian S, Nizet V, Knight R, Dorrestein PC. Chemical impacts of the microbiome across scales reveal novel conjugated bile acids.

Meier A, Chien J, Hobohm L, Patras KA, Nizet V, Corriden R. Propofol significantly decreases neutrophil extracellular trap (NET) production in fresh human neutrophils.

Ulloa ER, Dillon N, Tsunemoto H, Pogliano J, Sakoulas G, Nizet V.  Avibactam sensitizes carbapenem-resistant NDM-1-producing Klebsiella pneumoniae to innate immune clearance.

Patras KA, Ha AD, Rooholfada E, Olson J, RamachandraRao SP, Lin AE, Nizet V. Augmentation of urinary lactoferrin enhances host innate immune clearance of uropathogenic E. coli.

Escajadillo T, Popov LM, Dahesh S, Carette JE, Nizet V. Sterol regulatory element binding protein-2 (SREBP-2) influences host cell susceptibility to the bacterial pore-forming toxin streptolysin O.

Dillon N, Holland M, Tsunemoto H, Hancock B, Cornax I, Pogliano J, Sakoulas G, Nizet V. Dual bacterial translation inhibitors azithromycin and minocycline demonstrate synergy against multidrug-resistant Acinetobacter baumannii.

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