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Nature Communications Mu A, Klare WP, Baines SL, (multiple authors), Cole JN, Nizet V, (multiple authors), Stinear TP, Schembri MA, Walker MJ. Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria. Nat Commun 2023;14:1530. ABSTRACT | PDF
International Journal of
                ntimicrobial Agents Catteau L, Iglesias YD, Tsunemoto H, Pogliano J, Van Bambeke F, Nizet V, Sakoulas G. Nafcillin augmentation of daptomycin and cathelicidin LL-37 killing of methicillin-resistant Staphylococcus epidermidis: foundations of successful therapy of endocarditis. Int J Antimicrob Agents 2023; 61:106758. ABSTRACT | PDF
Journal of Medical
                Microbiology Anderson E, Nair B, Nizet V, Kumar G. Man vs microbes - the race of the century. J Med Microbiol 2023; 72(1). ABSTRACT | PDF
Journal of Infectious Diseases Osowicki J, Nizet V. Malice in Chains. J Infect Dis. 2023 Feb 7:jiad035. PDF
Iranian Journal of
                Microbiology Pashangeh S, Berizi E, Majlesi M, Ghaderi S, Nizet V, Dahesh S. Effect of eliminating hdcA gene of Staphylococcus epidermidis TYH1 on histamine production. Iran J Microbiol 2022;14:529-534. ABSTRACT | PDF
Nature Immunology Barajas-Mora EM, Lee L, Lu H, Valderrama JA, Bjanes E, Nizet V, Feeney AJ, Hu M, Murre C. Enhancer-instructed epigenetic landscape and chromatin compartmentalization dictate a primary antibody repertoire protective against specific bacterial pathogens. Nat Immunol 2023;24:320-336. ABSTRACT  | PDF
Current Research Microbial
                Sciences Kumaraswamy M, Coady A, Szubin R, Martin TC, Palsson B, Nizet V, Monk JM. Comprehensive whole genome sequencing with hybrid assembly of multi-drug resistant Candida albicans isolate causing cerebral abscess. Curr Res Microb Sci 2023;4:100180. ABSTRACT  |  PDF
Advanced Nanobiomed
                Research Bjanes E, Zhou J, Qayum T, Zurich RH, Menon ND, Hoffman A, Fang RH, Zhang L, Nizet V. Outer membrane vesicle-coated nanoparticle vaccine protects against Acinetobacter baumannii pneumonia and sepsis. Adv Nanobiomed Res 2023; 3:2200130. ABSTRACT  |  PDF
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mSystems Poudel S, Hefner Y, Szubin R, Sastry A, Gao Y, Nizet V, Palsson BO. Coordination of CcpA and CodY regulators in Staphylococcus aureus USA300 strains. mSystems. 2022 Nov 2:e0048022. Epub ahead of print.  ABSTRACT  |  PDF
Frontiers in
                Immunology Masso-Silva JA, Sakoulas G, Olay J, Groysberg V, Geriak M, Nizet V, Crotty Alexander LE, Meier A. Abrogation of neutrophil inflammatory pathways and potential reduction of neutrophil-related factors in COVID-19 by intravenous immunoglobulin. Front Immunol. 2022;13:993720.  ABSTRACT  |  PDF
Pharmacotherapy Thomas SP, Denizer E, Zuffa S, Best BM, Bode L, Chambers CD, Dorrestein PC, Liu GY, Momper JD, Nizet V, Tsunoda SM, Tremoulet AH. Transfer of antibiotics and their metabolites in human milk: Implications for infant health and microbiota. Pharmacotherapy 2022 (epub ahead of print)  ABSTRACT  |  PDF
Nature Materials Zhang F, Zhuang J, Li Z, Gong H, de Ávila BE, Duan Y, Zhang Q, Zhou J, Yin L, Karshalev E, Gao W, Nizet V, Fang RH, Zhang L, Wang J. Nanoparticle-modified microrobots for in vivo antibiotic delivery to treat acute bacterial pneumonia. Nat Mater 2022; 21:1324-1332.   ABSTRACT  |  PDF  |  Press Release 
Infectious Microbes and
                Diseases Siew R, Ou TL, Dahesh S, Akong K, Nizet V. Bicarbonate effects on antibacterial immunity and mucus glycobiology in the cystic fibrosis lung: a review with selected experimental observations. Infect Microb Dis 2022; 4:103-110. ABSTRACT  | PDF
mSystems Sorrentino JT, Golden GJ, Morris C, Painter CD, Nizet V, Campos AR, Smith JW, Karlsson C, Malmström J, Lewis NE, Esko JD, Gómez Toledo A. Vascular proteome responses precede organ dysfunction in a murine model of Staphylococcus aureus bacteremia. mSystems. 2022; 7:e0039522.  ABSTRACT  |  PDF 
Infectious Microbes and
                Diseases Bergmann R, Gulotta G, Andreoni F, Sumitomo T, Kawabata S, Zinkernagel AS Chhatwal GS, Nizet V, Rohde M, Uchiyama S. The group A Streptococcus interleukin-8 protease SpyCEP promotes bacterial intracellular survival by evasion of autophagy. Infect Microb Dis 2022; 4:116-123.  ABSTRACT  |  PDF 
ACS Omega Kapoor N, Uchiyama S, Pill S, Bautista L, Yin L, Regan M, Chu E. Rabara T, Wong M, Fairman J, Nizet V. Click chemistry-based technology for site-specific polysaccharide conjugation allows a bacterial protein to serve as both carrier and vaccine antigen. ACS Omega 2022; 7:24111-24120.  ABSTRACT  |  PDF
Cardiovascular Research Passos LSA, Nizet V, Levine RA, Aikawa E. Can we diagnose acute rheumatic fever early to maximize the success of secondary prophylaxis in rheumatic heart valve disease? Cardiovasc Res 2022; 118:e62-e65  ABSTRACT  |  PDF
Antimicrobial Agents and
                Chemotherapy Menon N, Penziner S, Montaño E, Zurich R, Pride D, Nair B, Kumar G, Nizet V. Increased innate immune susceptibility in hyperpigmented bacteriophage-resistant mutants of Pseudomonas aeruginosa. Antimicrob Agents Chemother 2022; July 6: e0023922 (online early)  ABSTRACT  |  PDF  |  Supplemental 
Microbial Pathogenesis Hirose Y, Kolesinski P, Hiraoka M, Uchiyama S, Zurich RH, Kumaraswamy M, Bjanes E, Yamaguchi M, Sumitomo T, Ghosh P,  Kawabata S, Nizet V. Contribution of Streptococcus pyogenes M87 protein to innate immune resistance and virulence.  Microb Pathogen 2022; 169:105636  ABSTRACT  |  PDF
eLife Kolesiński P, Wang KC, Hirose Y, Nizet V, Ghosh P. An M protein coiled coil unfurls and exposes its hydrophobic core to capture LL-37. ELife 2022; 11:e77989.  ABSTRACT  |  PDF
Open Forum Infectious
                Diseases Gilbertie J, Ulloa ER, Daiker JC, Nguyen K, Smelter D, Rose W, Geriak M, Schnabel LV, Nizet V, Sakoulas G, Potent activity of ertapenem plus cefazolin within staphylococcal biofilms: a contributing factor in the treatment of methicillin-susceptible Staphylococcus aureus endocarditis. Open Forum Infect Dis 2022; 5:ofac59  ABSTRACT  |  PDF   
Antimicrobial Agents and
                Chemotherapy Caffrey AR, Appaneal HJ, LaPlante KL, Lopes VV, Ulloa ER, Nizet V, Sakoulas G. Impact of clopidogrel on clinical outcomes in patients with Staphylococcus aureus bacteremia: A national retrospective cohort study. Antimicrob Agents Chemother 2022 Apr 13:e0211721 (online early)  ABSTRACT  |  PDF 
Food Science and Nutrition Pashangeh S, Shekarforoush SS, Aminlari M, Hosseinzadeh S, Nizet V, Dahesh S, Rahmdel S. Inhibition of histamine accumulation by novel histamine degrading species of Staphylococcus sp. isolated from goats and sheep milk. Food Sci Nutr 2022; 10:354-362.  ABSTRACT  |  PDF
Infectious Microbes and
                Diseases Moni M, Madathil T, Sathyapalan DT, Menon V, Gutjahr G, Edathadathil F, Sureshkumar D, Prasanna P, Jose S, Jerome R, Krishnan A, Pillai IC, Kumar G, Nair B, Nizet V, and Jayant A. Clinical efficacy of inhaled nitric oxide in preventing the progression of moderate to severe COVID-19 and its correlation to viral clearance—Results of a pilot study. Infect Microb Dis 2022; 4:26-33.  ABSTRACT   |  PDF
mSphere Mejia M, Ottinger S, Vrbanac A, Babu P, Zulk J, Moorshead D, Bode L, Nizet V, Patras K. Human milk oligosaccharides reduce murine group B Streptococcus vaginal colonization with minimal impact on the vaginal microbiota. mSphere 2022; 7:e00885-2.    ABSTRACT  |  PDF  
British Journal of Anaesthesia Corriden R, Schmidt B, Olson J, Okerblom J, Masso Silva J, Nizet V, Meier A. Dexmedetomidine does not directly inhibit neutrophil extracellular trap production. Brit J Anaesthes 2022; 128:e51-e54.  ABSTRACT  |  PDF
Journal of Antimicrobial
                Chemotherapy Holland ML, Bjanes E, Nizet V, Dillon NA. Bicarbonate modulates delafloxacin activity against multidrug-resistant Staphylococcus aureus and Pseudomonas aeruginosa. J Antimicrob Chemother  2022;77:433-442. ABSTRACT  |  PDF
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Scientific Reports Lee HW, Nizet V, An JN, Lee HS, Song YR, Kim SG, Kim JK. Uremic serum damages endothelium by provoking excessive neutrophil extracellular trap formation. Sci Rep 2021; 11:21439.  ABSTRACT  |  PDF
Frontiers in
                Microbiology Campeau A, Uchiyama S, Sanchez C, Sauceda C, Nizet V, Gonzalez D. The S protein of group B Streptococcus is a critical virulence determinant that impacts the cell surface virulome. Front Microbiol 2021; 12:729308.  ABSTRACT  | PDF
Frontiers in Cellular
                and Infection Microbiology Yamaguchi M, Kinjo Y, Nizet V. Editorial: Host-pathogen interactions during pneumococcal infection. Front Cell Infect Microbiol 2021; 11:752959. ABSTRACT  |  PDF 
Microorganisms Kumaraswamy M, Wiull K, Joshi B, Sakoulas G, Kousha A, Vaaje-Kolstad G, Johannessen M, Hegstad K, Nizet V, Askarian F. Bacterial membrane-derived vesicles attenuate vancomycin activity against methicillin-resistant Staphylococcus aureus. Microorganisms 2021; 9:2055.  ABSTRACT  |  PDF
mBio Golden G, Toledo A, Marki A, Sorrentino J, Morris C, Riley R, Spliid C, Chen Q, Cornax I, Lewis N, Varki N, Le D, Malmström J, Karlsson C, Ley K, Nizet V, Esko J. Endothelial heparan sulfate mediates hepatic neutrophil trafficking and injury during Staphylococcus aureus sepsis. mBio 2021; 12:e01181-21.  ABSTRACT  |  PDF 
Infection and Immunity Gao NJ, Rodas Lima E, Nizet V. Immunobiology of the classical Lancefield group A streptococcal carbohydrate antigen. Infect Immun 2021; 89:e00292-21.  ABSTRACT  |  PDF  
Engineering Kim JK, Uchiyama S, Gong H, Stream A, Zhang L, Nizet V. Engineered biomimetic platelet membrane-coated nanoparticles block Staphylococcus aureus cytotoxicity and protect against lethal systemic infection. Engineering 2021;  7:1149-1156.  ABSTRACT  |  PDF 
Science Signaling Rada C, Mejia-Pena H, Grimsey N, Canto Cordova I, Olson J, Wozniak J, Gonzalez DJ, Nizet V, Trejo J. Heat Shock Protein 27 activity is linked to endothelial barrier resolution induced by GPCR pro-inflammatory mediators. Sci Signal 2021;14,:eabc1044 ABSTRACT  |  PDF  |  Press Release
Immunology and Cell Biology Richter J, Monteleone M, Cork A, Barnett T, Nizet V, Brouwer S, Schroder K, Walker M. Streptolysins are the primary inflammasome activators in macrophages during Streptococcus pyogenes infection. Immunol Cell Biol 2021; 99:1040–1052   ABSTRACT  |  PDF
mSphere Sastry AV, Dillon N, Anand A, Poudel S, Hefner Y, Xu S, Szubin R, Feist AM, Nizet V, Palsson B. Machine learning of bacterial transcriptomes reveals responses underlying differential antibiotic susceptibility. mSphere 2021; 6:e0044321. ABSTRACT  | PDF
Communications Biology Machado H, Seif Y, Sakoulas G, Olson CA, Szubin R, Palsson BO, Nizet V, Adam M, Feist A. Environmental conditions dictate differential evolution of vancomycin resistance in Staphylococcus aureus. Commun Biol 2021; 4:793. ABSTRACT  |  PDF 
Clinical Infectious Diseases Rose WE, Fantl M, Geriak M, Nizet V, Sakoulas G. Current paradigms of combination therapy in methicillin-resistant Staphylococcus aureus (MRSA) bacteremia: does it work, which combination and for which patients? Clin Infect Dis 2021; 73:2353–60.  ABSTRACT  |  PDF
Journal of Infectious Diseases Ulloa ER, Uchiyama S, Gillespie R, Nizet V, Sakoulas G. Ticagrelor increases platelet-mediated Staphylococcus aureus killing resulting in clearance of bacteremia. J Infect Dis 202; 1224:1566–9. ABSTRACTPDF
Journal of Innate Immunity Lum G, Mercado V, van Ens D, Nizet V, Kimmey JM, Patras KA. Hypoxia-inducible factor 1 alpha is dispensable for host defense of group B Streptococcus colonization and infection. J Innate Immun 2021; 13:391–403. ABSTRACT  |  PDF
Cell Reports Hirose Y, Yamaguchi M, Sumitomo T, Nakata M, Hanada T, Okuzaki D, Motooka D, Mori Y, Kawasaki H, Coady A, Uchiyama S, Hiraoka M,  Zurich RH, Amagai M, Nizet V, Kawabata S. Streptococcus pyogenes upregulates arginine metabolism to exert its pathogenesis on the skin surface. Cell Reports 2021; 34:108924.  ABSTRACT  |  PDF
Science Translational Medicine Sun J, Uchiyama S, Olson J, Morodomi Y, Cornax I, Ando N, Kohno Y, Kyaw MMT, Aguilar B, Haste NM, Kanaji S, Kanaji T, Rose WE, Sakoulas G, Marth JD, Nizet V.  Repurposed drugs block toxin-driven platelet clearance by the hepatic Ashwell-Morell receptor to clear Staphylococcus aureus bacteremia. Sci Transl Med 2021; 13:eabd6737.  ABSTRACT  |  PDF  |  Supplemental | Press Release
Trends in Genetics Bier E, Nizet V. Driving to safety: CRISPR-based genetic approaches to reducing antibiotic resistance. Trends Genet 2021; 37:745-757.   ABSTRACT  |  PDF
Nature Communications Askarian F, Uchiyama S, Masson H, Bunaes AC, Golten O, Mekasha S, Røhr ÅK, Kommedal E, Ludviksen JA, Sørenson HV, Arntzen MØ, Schmidt B, van Sorge NM, Eijsink VG, Krengel U, Mollnes TE, Lewis NE, Nizet V, Vaaje-Kolstad G. The lytic polysaccharide monooxygenase CbpD promotes Pseudomonas aeruginosa virulence in systemic infection. Nat Commun 2021; 12:1230.  ABSTRACT  | PDF  |  Supplemental
Microbiology and Molecular
                Biology Reviews Bjanes E, Nizet V. More than a pore: non-lytic antimicrobial functions of complement and bacterial strategies for evasion. Microbiol Mol Biol Rev 2021; 85:e00177-20.   ABSTRACT  |  PDF  
mBio Saha S, Coady A, Sasmal A, Kawanishi K, Choudhury B, Yu H, Sorensen R, Inostroza J, Schoenhofen I, Chen X, Münster-Kühnel A, Sato C, Kitajima K, Ram S, Nizet V, Varki A. Exploring the impact of ketodeoxynonulosonic acid in host-pathogen interactions using uptake and surface display by nontypeable Haemophilus influenzae. mBio 2021; 12:e03226-20.  ABSTRACT  |  PDF
mSphere Cornax I, Zulk J, Olson J, Fulde M, Nizet V, Patras KA. Novel models of Streptococcus canis colonization and disease reveal modest contributions of M-like (SCM) protein. Microorganisms 2021; 9:183.  ABSTRACT  |  PDF
mSphere Menon ND, Kumar MS, Satheesh Babu TG, Bosee S, Vijayakumara G, Baswe M, Chatterjee M, D’Silva JR, Shetty K, Haripriyan J, Kumar A, Nair S, Somanath P, Nair BG, Nizet V, Kumar GB. A novel N4-like bacteriophage isolated from a wastewater source in South India with activity against several multidrug-resistant clinical Pseudomonas aeruginosa isolates. mSphere 2021; 6:e01215-20.  ABSTRACT  |  PDF 
Infectious Microbes and
                Diseases Gao NJ, Uchiyama S, Pill L, Dahesh S, Olson J, Bautista L, Maroju S, Berges A, Liu JZ, Zurich RH, van Sorge NM, Fairman F, Kapoor N, Nizet V. Site-specific conjugation of cell wall polyrhamnose to protein SpyAD envisioning a safe universal group A streptococcal vaccine. Infect Dis Microb 2021; 3:87-100.  ABSTRACT  |  PDF 
Gigascience Rajput A, Poudel S, Tsunemoto H, Meehan M, Szubin R, Olson CA, Seif Y, Lamsa A, Dillon N, Vrbanac A, Sugie J, Dahesh S, Monk JM, Dorrestein PC, Knight R, Pogliano P, Nizet V, Feist AM, Palsson BO. Identifying the effect of vancomycin on healthcare-associated methicillin-resistant Staphylococcus aureus strains using bacteriological and physiological media. GigaScience 2021; 10:giaa156.  ABSTRACT  |  PDF
Journal of Experimental
                Medicine Marki A, Buscher K, Lorenzini C, Meyer M, Saigusa R, Fan Z, Yeh YT, Hartmann N, Golden G, Dan J, Kiosses W, Ganesan R, Winkels H, Orecchioni M, McArdle S, Mikulski Z, Altman Y, Bui J, Kronenberg M, Esko J, Chien S, Nizet V, Smalley D, Roth J, Ley K. Elongated neutrophil-derived structures (ENDS) are novel blood borne microparticles formed by rolling neutrophils during sepsis. J Exp Med 2021; 218:e20200551.  ABSTRACT  |  PDF
Cell Host &
                Microbe Liu X, Kimmey JM, Matarazzo L, de Bakker V, Van Maele L, Sirard JC, Nizet V, Veening JW. Exploration of bacterial bottlenecks and Streptococcus pneumoniae pathogenesis by CRISPRi-seq. Cell Host Microbe 2021; 29:P107-120.E6 ABSTRACT  | PDF  |  Press Release
Journal of Infectious Diseases Wilde S, Olivares KL, Nizet V, Hoffman HM, Radhakrishna S, LaRock CN. Opportunistic invasive Infection by group A Streptococcus during anti-interleukin-6 immunotherapy. J Infect Dis 2021; 223:1260-1264.  ABSTRACT  |  PDF
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Infectious Microbes and
                Diseases Hirose Y, Yamaguchi M, Takemoto N, Miyoshi-Akiyama T, Sumitomo T, Nakata M, Ikebe T, Hanada T, Yamaguchi T, Kawahara R, Okuno R, Otsuka H, Matsumoto Y, Terashima Y, Kazawa Y, Nakanishi N, Uchida K, Akiyama Y, Iwabuchi K, Nakagawa C, Yamamoto K, Nizet V, Kawabata S. Genetic characterization of Streptococcus pyogenes emm89 strains isolated in Japan from 2011 to 2019.  Infect Microbe Dis 2020; 2:160-166.  ABSTRACT  |  PDF 
Journal of Immunology Washington A, Varki N, Valderrama JA, Nizet V, Bui JD. Evaluation of interleukin-17D in host immunity to group A Streptococcus infection. J Immunol 2020; 205:3122-3129.   ABSTRACT  |  PDF
PNAS Swanson S, Katkar G, Tam J, Pranadinata R, Chareddy Y, Coates J, Olson J, Nizet V, Kufareva I, Das S, Castillo V, Ghosh P. TLR4 signaling and macrophage inflammatory responses are dampened by GIV/Girdin. Proc Natl Acad Sci USA 2020; 117:26895-26906.   ABSTRACT  |  PDF
Clinical Infectious Diseases Ulloa ER, Singh KV, Geriak M, Haddad F, Murray BE, Nizet V, Sakoulas G.  Cefazolin and ertapenem salvage therapy rapidly clears persistent methicillin-susceptible Staphylococcus aureus bacteremia. Clin Infect Dis 2020; 71:1413-1418. ABSTRACT | PDF
mSystems Vrbanac A, Patras KA, Jarmusch AK, Mills RH, Shing S, Quinn RA, Vargas F, Gonzalez DJ, Dorrestein PC, Knight R, Nizet V. Evaluating organism-wide changes in the metabolome and microbiome following a single dose of antibiotic.  mSystems 2020; 5:e00340-20.  ABSTRACT  |  PDF  |  Supplemental
Nature Communications Brouwer S, Barnett TC, Ly D, Kasper KJ, De Oliveira DM, Rivera-Hernandez T, Cork AJ, McIntyre L, Jespersen MG, Richter J, Schulz BL, Dougan G, Nizet V, Yuen KY, You Y, McCormick JK, Sanderson-Smith ML, Davies MR, Walker MJ. Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes. Nat Comm  2020; 11:5018.  ABSTRACT  |  PDF
EBiomedicine Sun J, LaRock DL, Skowronski E, Kimmey JM, Olson J, Jiang Z, O’Donoghue AJ, Nizet V, LaRock CN. The Pseudomonas aeruginosa protease LasB directly activates IL-1β. EBiomedicine 2020; 60:102984. ABSTRACT  |  PDF 
Cell Wozniak JM, Mills RH, Olson J, Caldera JR, Poore GD, Carrillo-Terrazas M, Tsai CM, Vargas F, Knight R, Dorrestein PC, Liu GY, Nizet V, Sakoulas G, Rose W, Gonzalez DJ. Mortality risk profiling of Staphylococcus aureus bacteremia by multi-omic serum analysis reveals early predictive and pathogenic molecular signatures.  Cell 2020; 182:1067-1362.  ABSTRACT  |  PDF
mSystems Campeau A, Mills R, Blanchette M, Bajc K, Malfavon M, Munji R, Deng L, Hancock B, Patras K, Olson J, Nizet V, Daneman R, Doran K, and Gonzalez D.  Multi-dimensional proteome profiling of blood-brain barrier perturbation by group B Streptococcus. mSystems 2020; 5:e00368-20.  ABSTRACT  |  PDF 
mBio Chen YH, Li SH, Yang YC, Hsu SH, Nizet V, Chang YC. T4 pili promote colonization and immune evasion phenotypes
of non-encapsulated M4 Streptococcus pyogenes. mBio 2020; 11: e01580-20.  ABSTRACT  |  PDF 
Open Forum Infectious
                Diseases Berti I, Rose WE, Nizet V, Sakoulas G.  Antibiotics and innate immunity: a cooperative effort towards the successful treatment of infections.  Open Forum Infect Dis 2020; 7:ofaa302.  ABSTRACT  |  PDF  
Clinical Infectious Diseases Volk CF, Burgdorf S, Edwarson GW, Nizet V, Sakoulas G, Rose W. IL-1β and IL-10 host responses in patients with Staphylococcus aureus bacteremia determined by antimicrobial therapy.  Clin Infect Dis 2020; 70:2634-2640  ABSTRACT  |  PDF
ACS Chemical Biology Woehl JL, Kitamura S, Dillon N, Edgar LJ, Han Z, Nizet V, Wolan DW. An irreversible inhibitor to probe the role of Streptococcus pyogenes cysteine protease SpeB in evasion of host complement defenses.  ACS Chem Biol 2020; 15: 2060-2069.  ABSTRACT   |  PDF
PNAS Poudel S, Tsunemoto H, Seif Y, Sastry AV, Szubin R, Xu S, Machado H, Olson CA, Anand A, Pogliano J, Nizet V, Palsson BO. Revealing 29 sets of independently modulated genes in Staphylococcus aureus, their regulators and role in key physiological responses. Proc Natl Acad Sci 2020; 117:17228-17239.  ABSTRACT  |  PDF  |  Supplemental 
JACS Kitamura S, Zheng Q, Woehl, J, Solania A, Chen E, Dillon N, Hull M, Kotaniguchi M, Cappiello J, Kitamura S, Nizet V, Sharpless KB, Wolan D. Sulfur(VI) fluoride exchange (SuFEx)-enabled high-throughput medicinal chemistry. J Am Chem Soc 2020; 142:10899-10904.   ABSTRACT  |  PDF  |  Supplemental  
ChemBioChem Li Y, Fin A, Rovira A, Su Y, Dippel A, Valderrama JA, Riestra A, Nizet V, Hammond MC, Tor Y. Tuning the innate immune response to cyclic dinucleotides using atomic mutagenesis. ChemBioChem 2020; 21:2595-2598.  ABSTRACT  |  PDF 
iScience Lund SJ, Patras KA, Kimmey JM, Yamamura A, Butcher LD, Del Rosario PG, Hernandez GE, McCoy AM, Lakhdari O, Nizet V, Prince LS. Developmental immaturity of Siglec receptor expression on neonatal alveolar macrophages predisposes to severe group B streptococcal infection. iScience 2020; 23:101207.  ABSTRACT  |  PDF 
Science Advances Shewell LK, Day CJ, Jen FE, Haselhorst T, Atack JM, Reijneveld JF, Everest-Dass A, James DB, Boguslawski KM, Brouwer S, Gillen CM, Luo Z, Kobe B, Nizet V, von Itzstein M, Walker MJ, Adrienne W. Paton AW, Paton JC, Torres VJ,  Jennings MP. All major cholesterol-dependent cytolysins use glycans as cellular receptors.  Sci Adv 2020; 6:eaaz4926.  ABSTRACT  |  PDF
mSphere Patras K, Coady A, Babu P, Shing S, Ha A, Rooholfada E, Brandt S, Geriak M, Gallo RL, Nizet V. Host cathelicidin exacerbates group B Streptococcus urinary tract infection. mSphere 2020; 5:e00932-19.  ABSTRACT  |  PDF 
Trends in Immunology Lawrence SM, Corriden R, Nizet V. How neutrophils meet their end.  Trends Immunol 2020; 41:531-544.  ABSTRACT  |  PDF
mSystems Salazar M, Machado H, Dillon N, Tsunemoto H, Szubin R, Dahesh S, Pogliano J, Sakoulas G, Palsson BO, Nizet V, Feist A. Genetic determinants enabling media-dependent adaptation to nafcillin in methicillin-resistant Staphylococcus aureusmSystems 2020; 5:e00828-19.  ABSTRACT  |  PDF 
Advances in Experimental
                Medicine and Biology Chang YC, Nizet V. Siglecs at the host-pathogen interface. Adv Exp Med Biol 2020; 1204:197-214.  ABSTRACT  |  PDF
Scientific Reports Lee HS, Park MJ, Yoon SY, Joo N, Song YR, Kim HJ, Kim SG, Nizet V, Kim JK. Role of peribrachial fat as a key determinant of brachial artery dilatation for successful arteriovenous fistula maturation in hemodialysis patients.  Sci Rep 2020; 10:3841. ABSTRACT  |  PDF
Nature Quinn RA, Melnik AV, Vrbanac A, Fu T, Patras KA, Christy MP, Bodai Z, Belda-Ferre P, Tripathi A, Chung LK, Downes M, Welch RD, Quinn M, Humphrey G, Panitchpakdi M, Weldon KC, Askenov A, da Silva R, Avila-Pacheco J, Clish C, Bae S, Mallick H, Franzosa EA, Lloyd-Price J, Bussell R, Thron T, Nelson AT, Wang M, Leszczynski E, Vargas F, Gauglitz JM, Meehan MJ, Gentry E, Arthur TD, Komor AC, Poulsen O, Boland BS, Chang JT, Sandborn WJ, Lim M, Garg N, Lumeng JC, Xavier RJ, Kazmierczak BI, Jain R, Egan M, Rhee KE, Ferguson D, Raffatellu M, Vlamakis H, Haddad GG, Siegel D, Huttenhower C, Mazmanian SK, Evans RM, Nizet V, Knight R, Dorrestein PC. Global chemical impacts of the microbiome include novel bile acid conjugations.  Nature 2020;  579:123–129.  ABSTRACT  |  PDF  |  Supplemental  |  Press Release
Infectious Microbes &
                Diseases Ulloa ER, Kousha A, Tsunemoto H, Pogliano J, Licitra C, LiPuma JJ, Sakoulas G, Nizet V, Kumaraswamy M. Azithromycin exerts bactericidal activity and enhances innate immune-mediated killing of MDR Achromobacter xylosoxidans. Infect Microb Dis 2020; 2:10-17.  ABSTRACT  |  PDF
Frontiers in Cellular
                and Infection Microbiology Shing SR, Ramos AR, Patras KA, Riestra AM, McCabe S, Nizet V, Coady A.  The fungal pathogen Candida albicans promotes bladder colonization of group B StreptococcusFront Cell Infect Microbiol 2020; 9:437.  ABSTRACT  |  PDF  |  Supplemental
Genes and
                Development Denholtz M, Zhu Y, He Z, Lu H, Isoda T, Döhrmann S, Nizet V, Murre C.  Upon microbial challenge, human neutrophils undergo rapid changes in nuclear architecture and chromatin folding to orchestrate an immediate inflammatory gene program. Genes Dev 2020; 34:149-165.  ABSTRACT  |  PDF  |  Supplemental |  Cover Article
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Scientific Data Rajput A, Poudel S, Tsunemoto H, Meehan M, Szubin R, Olson CA, Lamsa A, Seif Y, Dillon N, Vrbanac A, Sugie J, Dahesh S, Monk JM, Dorrestein PC, Knight R, Nizet V, Palsson BO, Feist AM, Pogliano J. Profiling the effect of nafcillin on HA-MRSA D712 using bacteriological and physiological media.  Sci Data 2019; 6:322.  ABSTRACT  |  PDF
Profiling the effect of nafcillin on HA-MRSA D712 using bacteriological and physiological media
Nature Communications Valderrama JA, Kulkarni SS, Nizet V, Bier E. A bacterial gene-drive system efficiently edits and inactivates a high copy number antibiotic resistance locus. Nat Comm 2019; 10:5726.   ABSTRACT | PDF | Supplemental | Press Release
Journal of Innate Immunity Tsai CM, Riestra AM, Ali SR, Fong JJ, Liu JZ, Hughes G, Varki A, Nizet V.  Siglec-14 enhances NLRP3-inflammasome activation in macrophages. J Innate Immun 2019; 11:86-98.   ABSTRACT  |  PDF  |  Supplemental
Infectious Microbes &
                Diseases Tacke R, Sun J, Uchiyama S, Polovina A, Nguyen DG, Nizet V. Protection against lethal multidrug-resistant bacterial infections using macrophage cell therapy. Infect Microb Dis 2019; 1:61-69.   ABSTRACT  |  PDF 
Frontiers in
                Pediatrics Koo J, Escajadillo T, Zhang L, Nizet V, Lawrence SM. Erythrocyte-coated nanoparticles block cytotoxic effects of group B Streptococcus β-hemolysin/cytolysin.  Front Pediatr 2019; 7:410.  ABSTRACT  |  PDF 
Applied and Environmental
                Microbiology Machado H, Weng L, Dillon N, Seif Y, Holland M, Pekar J, Monk J, Nizet V, Palsson B, Feist A.  Strain-specific metabolic requirements revealed by a defined minimal medium for systems analyses of Staphylococcus aureus.  Appl Environ Microbiol 2019; 85:e01773-19.  ABSTRACT |  PDF
Nature Communications Gomez Toledo A, Golden G, Rosa-Campos A, Cuello H, Sorrentino J, Lewis N, Varki N, Nizet V, Smith JW, Esko JD. Proteomic atlas of organ vasculopathies triggered by Staphylococcus aureus sepsis.  Nat Comm 2019; 10:4656  ABSTRACT  |  PDF
Frontiers in
                Microbiology Gao NJ, Al-Bassam MM, Poudel S, Wozniak JM, Gonzalez DJ, Olson J, Zengler K, Nizet V, Valderrama JA. Functional and proteomic analysis of Streptococcus pyogenes virulence upon loss of its native Cas9 nuclease. Front Microbiol 2019; 10:1967.    ABSTRACT  |  PDF  |  Supplemental 
eLife Cohen-Katsenelson K, Stender JD, Uchiyama S, Grezchnik AT, Nizet V, Glass CK, Newton AC.  PH domain leucine rich repeat protein phosphatase 1 (PHLPP1) counter-regulates STAT1-mediated inflammatory signaling.  eLife  2019; 8:e48609.  ABSTRACT  |  PDF  |  Press Release
eBiomedicine Dillon N, Holland M, Tsunemoto H, Hancock B, Cornax I, Pogliano J, Sakoulas G, Nizet V. Dual bacterial translation inhibitors azithromycin and minocycline demonstrate synergy against multidrug-resistant Acinetobacter baumanniieBiomedicine 2019; 46:193-201.   ABSTRACT  |  PDF 
Journal of Biological
                Chemistry LaRock DL, Sands J, Ettouati E, Richard M, Bushway PJ, Adler ED, Nizet V, LaRock CN.  Inflammasome inhibition blocks cardiac glycoside cellular toxicity. J Biol Chem 2019; 294:12846-12854.  ABSTRACT  |  PDF    
Antimicrobial Agents and
                Chemotherapy Dahesh S, Wong B, Nizet V, Sakoulas G (Discussion by Tran TT, Aitken SL).  Treatment of multidrug-resistant vancomycin-resistant Enterococcus faecium hardware-associated vertebral osteomyelitis with oritavancin plus ampicillin. Antimicrob Agents Chemother 2019; 63:e02622-18.  ABSTRACT  |  PDF 
Journal of Innate Immunity Patras KA, Ha AD, Rooholfada E, Olson J, RamachandraRao SP, Lin AE, Nizet V. Augmentation of urinary lactoferrin enhances host innate immune clearance of uropathogenic E. coliJ Innate Immun 2019; 11:481-495.  ABSTRACT  |  PDF  |  Supplemental
mBio Rivera-Hernandez T, Carnathan D, Jones S, Cork A, Davies M, Moyle P, Toth I, Batzloff M, McCarthy J, Nizet V, Goldblatt D, Silvestri G, Walker MJ. An experimental group A Streptococcus vaccine that reduces pharyngitis and tonsillitis in a non-human primate model. mBio 2019; 10:e00693-19.   ABSTRACT  |  PDF  |  Supplemental
Scientific Data Poudel S, Tsunemoto H, Meehan M, Szubin R, Olson C, Lamsa A, Seif Y, Dillon N,Vrbanac A, Sugie J, Dahesh S, Monk J, Dorrestein P, Pogliano J, Knight R, Nizet V, Palsson B, Feist A. Characterization of CA-MRSA TCH1516 exposed to nafcillin in bacteriological and physiological media.  Sci Data 2019; 6:43.  ABSTRACT  |  PDF 
Journal of Infectious Diseases Ulloa ER, Dillon N, Tsunemoto H, Pogliano J, Sakoulas G, Nizet V.  Avibactam sensitizes carbapenem-resistant NDM-1-producing Klebsiella pneumoniae to innate immune clearance.  J Infect Dis 2019; 220:484-493.  ABSTRACT  |  PDF  |  Supplemental
EMBO Journal Zhang Q, Chao TC, Patil VS, Qin Y, Tiwari SK, Chiou J, Dobin A, Tsai CM, Li Z, Dang J, Gupta S, Urdahl K, Nizet V, Gingeras TR, Gaulton KJ, Rana TM. The long noncoding RNA ROCKI regulates inflammatory gene expression.  EMBO J 2019; 38:e100041.  ABSTRACT  |  PDF  |  Blog Post
PNAS Uchiyama S, Sun J, Fukahori K, Ando N, Wu M, Schwarz F, Siddiqui SS, Varki A, Marth JD, Nizet V.  Dual actions of group B Streptococcus capsular sialic acid provide resistance to platelet-mediated antimicrobial killing.  Proc Natl Acad Sci USA 2019; 116:7465-7470.   ABSTRACT  |  PDF  |  Blog Post 
Therapeutic Advances in
                Gastroenterology Caffrey AR, Timbrook TT, Ali SR, Nizet V, Sakoulas G. Proton pump inhibitors do not influence clinical outcomes in patients with Staphylococcus aureus bacteremia.  Therap Adv Gastroenterol 2019; 12:1756284819834273.  ABSTRACT  |  PDF
Frontiers in
                Pharmacology Meier A, Chien J, Hobohm L, Patras KA, Nizet V, Corriden R. Inhibition of human neutrophil extracellular trap (NET) production by propofol and lipid emulsion. Front Pharmacol 2019; 10:323.   ABSTRACT  |  PDF
Antimicrobial Agents and
                Chemotherapy Geriak M, Haddad F, Rizvi K, Rose W, Kullar R, LaPlante K, Yu M, Vasina L, Oueletter K, Zervos M, Nizet V, Sakoulas G.  Clinical data on daptomycin plus ceftaroline versus standard of care monotherapy in the treatment of methicillin-resistant Staphylococcus aureus bacteremia.  Antimicrob Agents Chemother 2019; 63:e02483-18.   ABSTRACT  |  PDF
Cell Chemical Biology Bauman KD, Li J, Murata K, Mantovani SM, Dahesh S, Nizet V, Luhavaya H, Moore BS.  Refactoring the cryptic streptophenazine biosynthetic gene cluster unites phenazine, polyketide, and nonribosomal peptide biochemistry.  Cell Chem Biol 2019; 6:724-736.   ABSTRACT  |  PDF  |  Supplemental
Virulence Nerlich A, Lapschies AM, Kohler TP, Cornax I, Eichhorn I, Goldmann O, Krienke P, Bergmann S, Nizet V, Hammerschmidt S, Rohde M, Fulde M.  Homophilic protein interactions facilitate bacterial aggregation and IgG-dependent complex formation by the Streptococcus canis M protein SCM. Virulence 2019; 10:194-206.   ABSTRACT  |  PDF 
Science Translational Medicine Dan JM, Havenar-Daughton C, Kendric K, Kaushik K, Rosales S, Anderson E, LaRock C, Pandurangan V, Seumois G,  Layfield D, Cutress R, Ottensmeier C, Lindestam Alrehman C, Sette A, Nizet V, Bothwell M, Brigger M, Crotty S. Recurrent tonsillitis is a genetic immunosusceptibility disease associated with poor antibody responses and aberrant T follicular helper cells.  Sci Transl Med 2019; 11:eaau3776  ABSTRACT  |  PDF  |  Supplemental  |  News
Clinical Infectious Diseases Walker MJ, Brouwer S, Forde BM, Worthing KA, McIntyre L, Sundac L, Maloney S, Roberts LW, Barnett TC, Richter J, Cork AJ, Irwin AD, You Y, Zhang J, Dougan G, Yuen KY, Nizet V, Beatson SA, Grimwold K, Davies MR.  Detection of epidemic scarlet fever group A Streptococcus in Australia.  Clin Infect Dis 2019; 69:1232-1234.  ABSTRACT  |  PDF
Chemical Biology & Drug
                Design Huang YM, Munguia J, Miao Y, Nizet V., McCammon JA. Docking simulation and antibiotic discovery targeting the MlaC protein in Gram-negative bacteria.  Chem Biol Drug Des 2019; 93:647-652.  ABSTRACT  |  PDF  
Anesthesia and Analgesia Meier A, Nizet V. Impact of anesthetics on human neutrophil function.  Anesth Analg  2019; 128:569-574  ABSTRACT  |  PDF
Cell Death &
                Differentiation Boeltz S, Amini P, (26 others), Nizet V, (16 others), von Köckritz-Blickwede M, (2 others), Herrmann M.  To NET or not to NET: Current opinions and state of the science regarding the formation of neutrophil extracellular traps.  Cell Death Differ 2019; 26:395-408.  ABSTRACT  |  PDF  |  Supplemental
Journal of Innate Immunity Riestra AM, Valderrama JA, Patras KA, Booth SD, Quek X, Tsai CM, Nizet V.  Trichomonas vaginalis induces NLRP3 inflammasome activation  and pyroptosis in human macrophages.  J Innate Immun 2019;11:86–98.    ABSTRACT  |  PDF
Clinical Infectious Diseases Sakoulas G, Geriak M, Nizet V. Is a question of penicillin allergy sufficient grounds to forgo the multidimensional antimicrobial benefits of β-Lactam antibiotics?  Clin Infect Dis 2019; 68:157-164.   ABSTRACT  |  PDF
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Toxins Escajadillo T, Nizet V. Pharmacological targeting of pore-forming toxins as adjunctive therapy for invasive bacterial infections.  Toxins  2018; 10:542.   ABSTRACT  |  PDF 
BMC Microbiology Vrbanac A, Riestra A, Coady A, Knight R, Nizet V, Patras KA. The murine vaginal microbiota and perturbation by the human pathogen group B Streptococcus. BMC Microbiol 2018; 18:197.    ABSTRACT  |  PDF  |  Supplemental   
International Journal of
                Pharmaceutics Uchiyama S, Dahesh S, Nizet V, Kessler J. Enhanced topical delivery of non-complexed molecular iodine for methicillin-resistant Staphylococcus aureus decolonization.  Int J Pharmaceut 2018; 554:81-86  ABSTRACT  |  PDF 
PLoS Pathogens van Hensbergen VP, Movert E, de Maat V, Le Breton Y, Lambeau G, Payre C, Kahn F, Henningham A, Nizet V, Van Strijp JA, Carlsson F, McIver KS,  van Sorge NM. Streptococcal Lancefield polysaccharides are critical cell wall determinants for human group IIA secreted phospholipase A2 to exert its bactericidal effects.  PLoS Pathogens 2018; 14:e1007348.  ABSTRACT  |  PDF  | Supplemental 
Infection and Immunity Coady A, Ramos AR, Olson J, Nizet V, Patras KA.   Tamm-Horsfall protein protects the urinary tract against Candida albicansInfect Immun 2018; 86: e00451-18.   ABSTRACT  |  PDF
Nature Communications Kavvas E, Catoiu E, Mih N, Yurkovich J, Seif Y, Dillon N, Heckmann D, Anand A, Yang L, Nizet V, Monk J, Palsson BO. Machine learning and structural analysis of Mycobacterium tuberculosis pan-genome identifies genetic signatures of antibiotic resistance.  Nat Commun 2018; 9:4306.   ABSTRACT  |  PDF  |  Supplemental 
Cell Host &
                Microbe Yang WH, Heithoff DM, Aziz P, Haslund-Gourney B, Westman JS, Narisawa S, Pinkerton AB, Millan JL, Nizet V, Mahan MJ, Marth JD.  Accelerated aging and clearance of host anti-inflammatory enzymes by discrete pathogens fuels sepsis. Cell Host Microbe 2018; 24:500-513.  ABSTRACT  |  PDF  |  Supplemental  |  Press Release 
PNAS Fong J, Tsai CM, Nizet V, Varki A, Bui J.  Siglec-7 Engagement by GBS β-protein suppresses pyroptotic cell death of natural killer cells.  Proc Natl Acad Sci USA 2018; 115:10410-10415.  ABSTRACT  |  PDF  |  Supplemental
PLoS Pathogens Alisson-Silva F, Liu J, Diaz S, Deng L, Gareau M, Chen X, Nizet V, Varki N, Barrett K, Varki A. Human evolutionary loss of epithelial Neu5Gc expression and the species-specific susceptibility to cholera.  PLoS Pathogens 2018; 14:e1007133.  ABSTRACT  |  PDF  |  Supplemental
FEMS Microbiology Reviews Askarian F, Wagner T, Johannessen M, Nizet V. Staphylococcus aureus modulation of innate immune responses through Toll-like (TLR),  (NOD)-like (NLR) and C-type lectin (CLR) receptors.  FEMS Microbiol Rev 2018; 42:656-671  ABSTRACT  |  PDF 
Journal of Infectious Diseases Patras KA, Derieux J, Al-Bassam MM, Adiletta N, Vrbanac A, Lapek JD, Zengler K, Gonzalez DJ, Nizet V. Group B Streptococcus biofilm regulatory protein A contributes to bacterial physiology and innate immune resistance.  J Infect Dis 2018; 218:1641-1652.   ABSTRACT  |  PDF  |  Supplemental 
Applied Microbiology &
                Biotechnology Kumaraswamy M, Collignon S, Do C, Kim J, Nizet V, Friend J. Decontaminating surfaces with atomized disinfectants generated by a novel thickness-mode lithium niobate device.  Appl Microbiol Biotechnol 2018; 102:6459-6467  ABSTRACT  | PDF  |  Supplemental
Frontiers in Cellular
                and Infection Microbiology Soderholm AT, Barnett TC, Korn O, Hernandez TR, Seymour LM, Schulz BL, Nizet V, Wells CA, Sweet MJ, Walker MJ. Group A Streptococcus M1T1 intracellular infection of primary tonsil epithelial cells dampens levels of secreted IL-8 through the action of SpyCEP.  Front Cell Infect Microbiol 2018; 8:160.  ABSTRACT  |  PDF  |  Supplemental
Frontiers in Medicine Gupta N, Nizet V. Stabilization of hypoxia-inducible factor 1-alpha augments the therapeutic capacity of bone marrow-derived mesenchymal stem cells in experimental pneumonia.  Front Med 2018; 5:131.  ABSTRACT  |  PDF  |  Supplemental
                Microbes van den Broek MFL, De Boeck I, Claes IJJ, Nizet V, Lebeer S. Multifactorial inhibition of lactobacilli against the respiratory tract pathogen Moraxella catarrhalis. Benef Microbes 2018; 9:429-439.  ABSTRACT  |  PDF 
Frontiers in
                Immunology Jati S, Kundu S, Chakraborty A, Mahata SK, Nizet V, Sen M.  Wnt5A signaling promotes defense against bacterial pathogens by activating a host autophagy circuit.  Front Immunol 2018; 9:679.   ABSTRACT  |  PDF  |  Supplemental 
Pharmacology Monogue M, Sakoulas G, Nizet V, Nicolau D.  Humanized exposures of a β-lactam-β-lactamase inhibitor, tazobactam, versus non-β-lactam-β-lactamase inhibitor, avibactam, with or without colistin, against Acinetobacter baumannii in murine thigh and lung infection models.   Pharmacology  2018; 101:255-261.     ABSTRACT  |  PDF 
Journal of Antimicrobial
                Chemotherapy Gupta N, Liu R, Shin S, Sinha R, Pogliano J, Pogliano K, Griffin JH, Nizet V, Corriden R.  SCH79797 improves outcomes in experimental bacterial pneumonia by boosting neutrophil killing and direct antibiotic activity. J Antimicrob Chemother 2018; 73:1586-1594.  ABSTRACT  |  PDF  |  Supplemental 
Frontiers in
                Pediatrics Patras KA, Nizet V. Group B streptococcal maternal colonization and neonatal disease: molecular mechanisms and preventative approaches.  Front Pediatr 2018; 6:27.  ABSTRACT |  PDF 
Scientific Reports Haripriyan J, Omanakuttan A, Menon ND, Vanuopadath M, Sadassivan Nair S, Corriden R, Nair BG, Nizet V, Kumar GB.  Clove bud oil modulates pathogenicity phenotypes of the opportunistic human pathogen Pseudomonas aeruginosa.  Sci Rep 2018; 8:3437.  ABSTRACT  |  PDF 
Frontiers in
                Microbiology Askarian F, Lapek JD, Tsai CM, Kumaraswamy M, Kousha A, Valderrama JA, Ludviksen JA, Cavanagh PJ, Uchiyama S, Mollnes TE, Gonzalez DJ, Wai SN, Nizet V, Johannessen M.  Staphylococcus aureus membrane-derived vesicles promote bacterial virulence and confer protective immunity in murine infection models. Front Microbiol 2018; 9:262.  ABSTRACT |  PDF
Advanced Healthcare Materials Chen Y, Chen M, Zhang Y, Lee JH, Escajadillo T, Gong H, Fang RH, Gao W, Nizet V, Zhang L.  Broad-spectrum neutralization of pore-forming toxins with human erythrocyte membrane-coated nanosponges.  Adv Health Mater 2018; 7:e1701366. ABSTRACT  |  PDF 
Microbiology and Molecular
                Biology Reviews Lawrence SM, Corriden R, Nizet V.  The ontogeny of a neutrophil: mechanisms of granulopoiesis and homeostasis. Microbiol Mol Biol Rev 82:e00057-17.   ABSTRACT  |  PDF
Stem Cells Gupta N, Sinha R, Krasnodembskaya A, Xu X, Nizet V, Matthay MA, Griffin JH. The TLR4-PAR1 axis regulates bone marrow mesenchymal stromal cell survival and therapeutic capacity in experimental bacterial pneumonia. Stem Cells  2018; 36:796-806.   ABSTRACT  |  PDF
Scientific Reports Choe D,  Szubin R,  Dahesh S,  Cho; S, Nizet V, Palsson BO, Cho BK. Genome-scale analysis of methicillin-resistant Staphylococcus aureus USA300 reveals a tradeoff between pathogenesis  and drug resistance.  Sci Rep 2018; 8:2215.  ABSTRACT  |  PDF 
International Journal of
                Antimicrobial Agents Kumaraswamy M, Do C, Sakoulas G, Nonejuie P, Tseng GW, King H, Fierer J, Pogliano J, Nizet V.  Listeria monocytogenes endocarditis: Case report, review of the literature, and laboratory evaluation of potential novel antibiotic synergies.  Int J Antimicrob Agents 2018; 51:468-478.  ABSTRACT   |  PDF  |  Supplemental
mBio Henningham A, Davies MR, Uchiyama S, Van Sorge NM, Lund S, Bannon K, Walker MJ, Cole JN, Nizet V.  Virulence role of the GlcNAc side-chain of the Lancefield cell wall carbohydrate antigen in non-M1 serotype group A StreptococcusmBio 2018; 9:e02294-17.  ABSTRACT  |  PDF 
Frontiers in Cellula
                & Infection Microbiology Liu JZ, Ali SR, Bier E, Nizet V.  Innate immune interactions between Bacillus anthracis and host neutrophils.  Front Cell Infect Microbiol 2018; 8:2.   ABSTRACT  |  PDF  |  Supplemental
Future Microbiology Valderrama JA, Nizet V. Group A Streptococcus encounters with host macrophages.  Future Microbiol 2018; 13:119-134.  ABSTRACT  |  PDF 
Human Molecular Genetics Mesci P, Macia A, LaRock CN, Tejwani L, Fernandes IR, Suarez NA, Zanotto PM, Beltrão-Braga PC, Nizet V, Muotri AR. Modeling neuro-immune interactions during Zika virus infection.  Human Mol Genet 2018; 27:41-52.  ABSTRACT  |  PDF
Journal of Infectious Diseases Andreoni, F, Ugolini F, Keller N, Neff A, Nizet V, Hollands A, Marques-Maggio E, Zinkernagel A, Schuepbach R.  Immunoglobulin attenuates streptokinase-mediated virulence in Streptococcus dysgalactiae subsp. equisimilis necrotizing fasciitis.  J Infect Dis 2018; 217:270-279.  ABSTRACT  |  PDF 
Journal of Natural Products Mascuch SJ, Boudreau PD, Carland TM, Pierce NT, Olson J, Hensler ME, Choi H, Campanale J, Hamdoun A, Nizet V, Gerwick WH, Gaasterland T, Gerwick L. The marine natural product honaucin A attenuates inflammation by activating the Nrf2-ARE pathway.  J Nat Prod 2018;  81:506-514  ABSTRACT  |  PDF  |  Supplemental
Journal of
                Antibiotics Reynolds KA, Luhavaya H,  Li J, Dahesh S, Nizet V, Moore BS.  Isolation and structure elucidation of lipopeptide antibiotic taromycin B from the activated taromycin biosynthetic gene cluster.  J Antibiot 2018;71:333-338  ABSTRACT  |  PDF
Journal of Antimicrobial
                Chemotherapy Britt N, Tirmizi S, Ritchie D, Topal J, McManus D, Nizet V, Casabar E, Sakoulas G. Telavancin for refractory methicillin-resistant Staphylococcus aureus bacteremia in intermittent hemodialysis recipients.  J Antimicrob Chemother 2017;  73: 764-767. ABSTRACT  |  PDF
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Science Yang WH, Heithoff DM, Aziz PV, Sperandio M, Nizet V, Mahan MJ, Marth JD.  Recurrent Salmonella infection progressively disables host protection against intestinal inflammation.  Science 2017; 358:eaao5610.  ABSTRACT  |  PDF  |  Supplemental  |  Press Release  |  Blog Post
Molecules Catteau L, Reichmann NT, Olson J, Pinho M, Nizet V, van Bambeke F, Quetin-LeClercq J.  Synergy between ursolic and oleanolic acids from Vitellaria paradoxa leaf extract and β-lactams against methicillin-resistant Staphylococcus aureus: in vitro and in vivo activity and underlying mechanisms.  Molecules 2017; 22:2245.  ABSTRACT  |  PDF 
mSphere Sakoulas G, Kumaraswamy M, Kousha A, Nizet V.  Interaction of antibiotics with innate host defense factors against Salmonella enterica serotype Newport.  mSphere  2017; 2:e00410-17.  ABSTRACT  |  PDF 
ACS Nano Zhang Y, Gao W, Chen Y, Escajadillo T, Ungerleider JL, Fang RH, Christman KL, Nizet V, Zhang L. Self-assembled colloidal gel using cell membrane-coated nanosponges as building blocks.  ACS Nano 2017; 11:11923-11930.   ABSTRACT  |  PDF
PNAS Thamphiwatana S*, Angsantikul P*, Escajadillo T*, Zhang Q, Olson J, Luk BT, Zhang S, Fang RH, Gao W, Nizet V, Zhang L. Macrophage-like nanoparticles concurrently absorbing endotoxins and proinflammatory cytokines for sepsis management.  Proc Natl Acad Sci USA 2017; 114:11488-11493.   ABSTRACT  |  PDF 
PLoS Pathogens Guichard A, Jain P, Moayeri M, Schwarz R, Chin S, Zhu L, Cruz-Moreno B, Liu JZ, Aguilar B, Hollands A, Leppla SH, Nizet V, Bier E.  Anthrax edema toxin disrupts distinct steps in Rab11-dependent junctional transport.  PLoS Pathog 2017; 13:e1006603.  ABSTRACT  |  PDF  |  Supplemental 
Nature Communications Sun J, Lei L, Tsai CM, Wang Y, Shi Y, Ouyang M, Lu S, Seong J, Kim T, Wang P, Huang M, Xu X, Nizet V, Chien S, Wang Y. Engineered proteins with sensing and activating modules for automated reprogramming of cellular functions.  Nat Commun 2017; 8:477.  ABSTRACT  |  PDF  |  Supplemental  |  Movie 1  | Movie 2  |  Movie 3  |  Movie 4   
Journal of Molecular Medicine Munguia J, LaRock D, Tsunemoto H, Olson J, Cornax I, Pogliano J, Nizet V. The Mla pathway is critical for Pseudomonas aeruginosa resistance to outer membrane permeabilization and host innate immune clearance. J Mol Med 2017; 95:1127–1136.  ABSTRACT  |  PDF 
Immunology & Cell BIology Patras KA, Coady A, Olson J, Ali SR, RamachandraRao S, Varki A, Nizet V.  Tamm-Horsfall glycoprotein engages human Siglec-9 to modulate neutrophil activation in the urinary tract.  Immunol Cell Biol 2017; 95:960-965.  ABSTRACT  |  PDF  |  Supplemental 
Nature Microbiology Valderrama JA, Riestra A, Gao NJ, LaRock CN, Gupta N, Ali SR, Hoffman HM, Ghosh P, Nizet V.  Group A streptococcal M protein activates the NLRP3 inflammasome.  Nat Microbiol 2017; 2;1425–1434.   ABSTRACT  |  PDF  |  Supplemental  |  Commentary  |  Press Release  |  NBC 7 News  |  KUSI News 
Frontiers in
                Pharmacology Escajadillo T, Olson J, Luk BT, Zhang L, Nizet V.  A red blood cell membrane-camouflaged nanoparticle counteracts streptolysin O‑mediated virulence phenotypes of invasive group A StreptococcusFront Pharmacol 2017;  8:477.  ABSTRACT  |  PDF  |  Supplemental 
Antimicrobial Agents &
                Chemotherapy Schooley R, Biswas B, Gill JJ, Hernandez-Morales A, Lancaster J, Lessor L, Barr JJ, Reed SL, Rohwer F, Benler S, Segall AM, Taplitz R, Smith DM, Kerr K, Kumaraswamy M, Nizet V, Lin L, McCauley MD, Strathdee SA, Benson CA, Leroux BM, Pope RK, Picel AC,  Mateczun AJ, Cilwa KE, Regeimbal JM, Estrella LA, Wolfe DM, Henry MS, Quinones J, Salka S, Bishop-Lilly KA, Young R, Hamilton T. Development and use of personalized bacteriophage-based therapeutic cocktails to treat a patient with a disseminated resistant Acinetobacter baumannii infection. Antimicrob Agents Chemother 2017; 61:e00954-17.   ABSTRACT  |  PDF  |  Supplemental  |  The Amazing Story 
Journal of Biological
                Chemistry Lin AE, Autran CA, Szyszka A, Escajadillo T, Huang M, Godula K, Prudden AR, Boons GJ, Lewis AL, Doran KS, Nizet V,
Bode L. Human milk oligosaccharides inhibit growth of group B Streptococcus. J Biol Chem 2017; 92;11243–11249.  ABSTRACT  |  PDF
eBiomedicine Nizet V.  The accidental orthodoxy of Drs. Mueller and Hinton.  EBiomedicine 2017;22:26-27  PDF
Journal of Molecular Medicine Severino P, Ariga SK, Barbeiro HV, de Lima TM, de Paula Silva E, Barbeiro DF, Machado MC, Nizet V, Pinheiro da Silva F.  Cathelicidin-deficient mice exhibit increased survival and upregulation of key inflammatory response genes following cecal ligation and puncture.  J Mol Med 2017; 95:995–1003.  ABSTRACT  |  PDF
Blood Lizcano A, Secundino I, Döhrmann S, Corriden R, Deng L, Diaz S, Nizet V, Varki A. Erythrocyte sialoglycoproteins engage Siglec-9 on neutrophils to suppress activation.  Blood 2017; 29:3100-3110.  ABSTRACT   |  PDF
Trends in Pharmacological
                Sciences Munguia J, Nizet V.  Pharmacological targeting of the host-pathogen interaction: Alternatives to classical antibiotics to combat drug-resistant superbugs.  Trend Pharm Sci 2017; 38:473-488.   ABSTRACT  |  PDF 
Frontiers in
                Pediatrics Lawrence SM, Corriden R, Nizet V.  Age-appropriate functions and dysfunctions of the neonatal neutrophil.  Front Pediatr 2017; 5:23.  ABSTRACT  |  PDF  
Antimicrobial Agents &
                Chemotherapy Caffrey AR, Timbrook T, Noh E, Sakoulas G, Opal SM, Nizet V, LaPlante KL. Evidence to support continuation of statin therapy in patients with Staphylococcus aureus bacteremia. Antimicrob Agents Chemother 2017; 61:e02228-16.  ABSTRACT  |  PDF  |  Supplemental
Scientific Reports Döhrmann S, LaRock CN, Anderson EL, Cole JN, Ryali B, Stewart C, Nonejuie P, Pogliano J, Corriden R, Ghosh P,  Nizet V.  Group A streptococcal M1 protein provides resistance against the antimicrobial activity of histones. Sci Rep 2017; 7:43039.  ABSTRACT  |  PDF  |  Supplemental
Clinical Infectious Diseases Rose WE, Berti AD, Hayney MS, Henriquez K, Ranzoni A, Cooper MA, Skukla SK, Proctor RA, Nizet V, Sakoulas G. Increased endovascular Staphylococcus aureus inoculum is the link between elevated serum IL-10 concentrations and mortality in patients with bacteremia.  Clin Infect Dis 2017; 64:1406-1412.   ABSTRACT  |  PDF
Antimicrobial Agents &
                Chemotherapy Sakoulas G, Rose W, Berti A, Olson J, Munguia J, Nonejuie P, Sakoulas E, Rybak MJ, Pogliano J, Nizet V.  Classical β-lactamase inhibitors potentiate the activity of daptomycin against methicillin-resistant Staphylococcus aureus and colistin against Acinetobacter baumannii. Antimicrob Agents Chemother 2017; 61: e01745-16.   ABSTRACT  |  PDF 
Journal of Immunology Okerblom J, Schwarz F, Olson J, Fletes W, Ali SR, Martin PT, Glass CK, Nizet V, Varki A. Loss of CMAH during human evolution primed the monocyte-macrophage lineage towards a more inflammatory and phagocytic state.  J Immunol 2017; 198:2366-2373.   ABSTRACT  |  PDF 
mBio De Oliveira DM, Hartley-Tassel L, Everest-Dass A, Day CJ, Dabbs R, Ve T, Kobe B, Nizet V, Packer NH, Walker MJ, Jennings MP, Sanderson-Smith ML. Blood group antigen recognition via the group A streptococcal M protein mediates host colonization. mBio 2017; 8:e02237-16.  ABSTRACT  |  PDF
EMBO Journal Schwarz F, Landig C, Siddiqui S, Secundino I, Garcia-Bingman A, Olson J, Varki N, Nizet V, Varki A.  Paired Siglec receptors generate opposite inflammatory responses to a human-specific pathogen.  EMBO J 2017; 36:751-760.  ABSTRACT  |  PDF 
mBio van Wijk XM, Döhrmann S, Voldborg BG, Hallström BM, Li S, Meng BX, McKee KK, van Kuppevelt TH, Yurchenco PD, Palsson BO, Lewis NE, Nizet V, Esko JD.  Whole genome sequencing of invasion-resistant cells identifies laminin alpha 2 as a host factor for bacterial invasion. MBio 2017; 8:e02128-16.  ABSTRACT  |  PDF  
American Journanl of
                Respiratory Cell & Molecular Biology Storisteanu DM, Pocock JM, Cowburn AS, Juss JK Nadesalingam A, Nizet V, Chilvers ER.  Evasion of neutrophil extracellular traps by respiratory pathogens.  Am J Respir Cell Mol Biol 2017;56:423-431.  ABSTRACT |  PDF
PPPID, 5th Edition Arnold JC, Nizet V.  Chapter 27: Pharyngitis, pp. 202-208 and Nizet V, Arnold JC. Chapter 118:  Streptococcus pyogenes (group A Streptococcus), pp. 715-723.  In: Principles and Practices of Pediatric Infectious Diseases, 5th Edition (S Long, CG Prober, Fischer M, eds.). Elsevier, Philadelphia,  2017.  Pharyngitis PDF  |  GAS PDF
Essentials of
                Glycobiology, 3rd Edition
Nizet V, Varki A, Aebi M. Microbial lectins: hemagglutinins, adhesins, and toxins. In: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Darvill AG, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH, editors. Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor Laboratory Press. Chapter 37.   ABSTRACT  |  Full Text 

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PLoS Biology Sorg RA, Lin L, van Doorn S, Sorg M, Olson J, Nizet V, Veening JW.  Collective resistance in microbial communities by intracellular antibiotic deactivation.  PLoS Biol 2016; 14:e2000631.  ABSTRACT  |  PDF  |  Supplemental
Annals of Translational
                Medicine Coady A, Nizet V.  SAMP-ening down sepsis. Ann Transl Med 2016; 4:509.   ABSTRACT  |  PDF
Frontiers in
                Immunology Flores R, Döhrmann S, Schaal C, Hakkim A, Nizet V, Corriden R. The selective estrogen receptor modulator raloxifene inhibits neutrophil extracellular trap formation.  Front Immunol  2016; 7:566.  ABSTRACT  |  PDF
Infection & Immunity Askarian F, Uchiyama S, Valderrama JA, Ajayi C, Sollid JE, van Sorge NM, Nizet V, van Strijp JA, Johannessen M.  Serine-aspartate-repeat protein D increases Staphylococcus aureus virulence and survival in blood. Infect Immun 2016; 85:e00559-16   ABSTRACT  |  PDF  |  Supplemental
Nature Microbiology Buffalo CZ, Bahn-Suh AJ, Hirakis SP, Biswas T, Amaro RE, Nizet V, Ghosh P.  Conserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein.  Nat Microbiol 2016; 1:16155.  ABSTRACT  |  PDF  |  Supplemental  |  Press Release
Cell Host &
                Microbe Hentrich K, Löfling J, Pathak A, Nizet V, Varki A, Henriques-Normark B.  Streptococcus pneumoniae senses a human-like sialic acid profile via the response regulator CiaR.  Cell Host Microbe 2016; 20:307-17.  ABSTRACT  |  PDF  |  Press Release 
Antimicrobial Agents &
                Chemotherapy Sakoulas G, Olson J, Yim J, Singh NB, Kumaraswamy M, Quach DT, Rybak MJ, Pogliano J, Nizet V. Cefazolin and ertapenem: A synergistic combination used to clear persistent Staphylococcus aureus bacteremia.  Antimicrob Agents Chemother 2016; 60:6609-6618.  ABSTRACT   |  PDF
Science Immunology LaRock CN, Todd J, LaRock D, Olson J, O’Donoghue AJ,  Robertson AA, Cooper MA, Hoffman HM, Nizet V. IL-1β is an innate immune sensor of microbial proteolysis.  Sci Immunol 2016; 1:eaah3539.   ABSTRACT  |  PDF  |  Supplemental  |  Invited Commentary  |  Interview 
PNAS Stewart C, Valderamma JA, Henningham A, Cole JN, Nizet V, Ghosh P.   Coiled-coil destabilizing residues in the group A Streptococcus M1 protein are required for functional interaction. Proc Natl Acad Sci USA 2016; 13:9515-20.  ABSTRACT  |  PDF  |  Supplemental
Synthesis Sganappa A, Bellucci MC, Nizet V, Tor Y, Volonterio A.  Multicomponent domino synthesis and antibacterial activity of neomycin-sugar conjugates. Synthesis 2016; 48: 4443-4450.  ABSTRACT  |  PDF  |  Supplemental
PLoS Pathogens Döhrmann S, Cole JN, Nizet V.  Conquering neutrophils.  PLoS Pathog 2016; 12:e1005682.  ABSTRACT  |  PDF 
Early Human
                Development Makoni M, Eckert J, Pereira HA, Nizet V, Lawrence SM.  Alterations in neonatal neutrophil function attributable to increased immature forms.  Early Hum Dev 2016; 103:1-7.   ABSTRACT  |  PDF
Scientific Reports Yamaguchi M, Hirose Y, Nakata M, Uchiyama S, Yamaguchi Y, Goto K, Sumitomo T, Lewis AL, Kawabata S, Nizet V.  Evolutionary inactivation of a sialidase in group B Streptococcus. Sci Rep 2016; 6: 28852.   ABSTRACT  |  PDF  |  Supplemental
PNAS Bosil E, Monk J, Aziz RK, Fondi M, Nizet V. Palsson BO.  Comparative genome-scale modeling of multiple Staphylococcus aureus strains identifies unique metabolic capabilities linked to pathogenicity.  Proc Natl Acad Sci USA 2016; 13:E3801-9. ABSTRACT  |  PDF  |  Press Release
mBio Rivera-Hernandez T, Pandey M, Henningham A, Cole JN, Choudhury B, Walker A, Duplanic C, Abdul Ghaffar K, West NP, Silvestri G, Good M, Moyle P, Toth I, Nizet V, Batzloff M, Walker MJ.  Differing efficacy of lead group A streptococcal vaccine candidates and full-length M protein in cutaneous and invasive disease models.  mBio 2016; 7:e00618-16.  ABSTRACT  |  PDF  
Scientific Reports Carey AJ, Weinberg JB, Dawid SR, Venturini C, Lam AK, Nizet V, Caparon M, Walker MJ, Watson ME, Ulett GC.  Interleukin-17A controls Streptococcus pyogenes colonization and inflammation of the female genital tract. Sci Rep 2016; 6:26836.  ABSTRACT  |  PDF 
EJCMID Le J, Dam Q, Schweizer M, Thienphrapa W, Nizet V, Sakoulas G.  Effects of vancomycin versus nafcillin in enhancing killing of methicillin-susceptible Staphylococcus aureus bacteremia by human cathelicidin LL-37.  Eur J Clin Microbiol Infect Dis  2016; 35:1441-1447.  ABSTRACT  |  PDF 
Journal of Biological
                Chemistry Hollands A, Corriden R, Gysler G, Dahesh S, Olson J, Kunkel MT, Lin AE, Forli S, Newton AC, Kumar GB, Nair BG, Perry JJP, Nizet V. Natural product anacardic acid from cashew nut shells stimulates neutrophil extracellular trap production and bactericidal activity.  J Biol Chem 2016; 291:13964-13973.   ABSTRACT  |  PDF  |  Blog
Antimicrobial Agents &
                Chemotherapy Lin L, Kim J, Chen H, Nizet V.  Component analysis of multi-purpose contact lens solutions to enhance activity against Pseudomonas aeruginosa and Staphylococcus aureusAntimicrob Agents Chemother 2016; 60:4259-4263.  ABSTRACT  |  PDF  |  Supplemental  |  Local News Story
Protein Science Huang YM, Miao Y, Munguia J, Lin L, Nizet V, McCammon JA. Molecular dynamic study of MlaC protein in Gram-negative bacteria: conformational flexibility, solvent effect and protein-phospholipid binding.  Protein Sci 2016; 25:1430-1437.  ABSTRACT  |  PDF
Bioscience Reports Völlger L, Akong-Moore KA, Cox L, Goldmann O, Wang Y, Schäfer S, Naim H, Nizet V, von Köckritz-Blickwede M. Iron chelating agent desferrioxamine stimulates formation of neutrophil extracellular traps (NETs) in human blood-derived neutrophils.  Biosci Rep 2016; 36:e00333.  ABSTRACT   |  PDF 
Frontiers in
                Microbiology von Köckritz-Blickwede M, Blodkamp S, Nizet V. Interaction of bacterial exotoxins with neutrophil extracellular traps: impact for the infected host. Front Microbiol  2016; 7:402.  ABSTRACT  |  PDF
Journal of Antimicrobial
                Chemotherapy Kumaraswamy M, Lin L, Olson J, Sun C-F, Nonejuie P, Corriden R, Döhrmann S, Ali SR, Amara D, Rohde M, Pogliano J, Sakoulas G, Nizet V.  Standard susceptibility testing masks potent azithromycin activity and cationic peptide synergy against multidrug-resistant Stenotrophomonas maltophiliaJ Antimicrob Chemother 2016; 71:1264-9.   ABSTRACT  |  PDF    Supplemental 
Microbiology Spectrum Cole JN, Nizet V. Bacterial evasion of host antimicrobial peptide defenses. Microbiol Spectrum 2016; 4:VMBF- 0006-2015.  ABSTRACT  |  PDF 
eBiomedicine Quach DT, Sakoulas G, Nizet V, Pogliano J, Pogliano K. Bacterial cytological profiling (BCP) as a rapid and accurate antimicrobial susceptibility testing method for Staphylococcus aureus. eBiomedicine 2016; 4: 95-103.   ABSTRACT  |  PDF  |   Press Release 
Antimicrobial Agents &
                Chemotherapy Berti AD, Theisen E, Demain-Sauer J, Nonejuie N, Olson J, Pogliano J, Sakoulas G, Nizet V, Proctor RA, Rose WE. Penicillin binding protein 1 is important in the compensatory response of Staphylococcus aureus to daptomycin-induced membrane damage and is a potential target for β-lactam-daptomycin synergy. Antimicrob Agents Chemother 2016; 60:451-458.  ABSTRACT  |  PDF  |  Supplemental 
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Cell Host &
                Microbe Kolar S, Kyme P, Tseng CW, Soliman A, Kaplan A, Liangó J, Nizet V, Jiang D, Murali R, Arditi M, Underhill DM, Liu GY.  Group B Streptococcus evades host immunity by degrading hyaluronan.  Cell Host Microbe 2015; 18:694-704.  ABSTRACT  |  PDF  |  Cover Image
Frontiers in
                Immunology Uchiyama S, Döhrmann S, Timmer AM, Dixit N, Ghochani M, Bhandari T, Timmer JC, Sprague K, Bubeck-Wardenburg J, Simon SI and Nizet V (2015) Streptolysin O rapidly impairs neutrophil oxidative burst and antibacterial responses to group A Streptococcus. Front Immunol 2015; 6:581.  ABSTRACT  |  PDF  |  Supplemental 
Cell Host &
                Microbe LaRock CN, Döhrmann S, Todd J, Corriden R, Olson J, Johannssen T, Lepenies B, Gallo RL, Ghosh P, Nizet V.  Group A streptococcal M1 protein sequesters cathelicidin to evade immune killing. Cell Host Microbe 2015; 18:471-477.   ABSTRACT  |  PDF  |  CommentaryPress Release
Nature Communications Corriden R, Hollands A, Olson J, Derieux J, Lopez JM, Gonzalez DJ, Nizet V. Tamoxifen augments the innate immune function of neutrophils through modulation of intracellular ceramide.  Nat Comm 2015; 6:8369.  ABSTRACT  |  PDF  |  Supplemental  |  Press Release  |  Union-Tribune  |  Huffington Post  |  Washington Post 
EMBO Journal Fong JJ, Sreehara K, Deng L, Varki NM, Angata T, Liu Q, Nizet V, Varki A.  Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14.  EMBO J 2015; 34:2775-88.  ABSTRACT  |  PDF  |  Graphical Abstract
Frontiers in
                Immunology LaRock CN, Nizet V. Inflammasome/IL-1β responses to streptococcal pathogens.  Front Immunol 2015; 6:518.  ABSTRACT  |  PDF
                Microbiology Barnett T, Cole JN, Rivera Hernandez T, Henningham A, Paton J, Nizet V, Walker MJ. Streptococcal toxins: role in pathogenesis and disease. Cell Microbiol 2015; 17:1721-41.   ABSTRACT  |  PDF 
Journal of Molecular Medicine Secundino I, Lizcano A, Roupé KM, Wang X, Cole JN, Ali SR, Dahesh S, Amayreh LK, Henningham A, Varki A, Nizet V.  Host and pathogen hyaluronan signal through human Siglec-9 to suppress neutrophil activation. J Mol Med 2015; 94:219-33.   ABSTRACT  |  PDF 
Journal of Cell Biology Grimsey NJ, Aguilar B, Smith TH, Le PN, Soohoo A, Puthenveedu MA, Nizet V, Trejo J.  Ubiquitin plays an atypical role in GPCR-induced p38 MAP kinase activation on endosomes.  J Cell Biol 2015; 210:1117-1131.  ABSTRACT  |  PDF
PLoS One Pence MA, Haste NM, Sabhatu HM, Olson J, Gallo RL, Nizet V, Kristian SA.  Beta-lactamase repressor BlaI modulates Staphylococcus aureus cathelicidin antimicrobial peptide resistance and virulence. PLoS One 2015; 10:e0136605  ABSTRACT  |  PDF
Antimicrobial Agents &
                Chemotherapy Sakoulas G, Kumaraswamy M, Nonejuie P, Werth B, Rybak MJ, Pogliano J, Rice LB, Nizet V.  Differential effects of penicillin-binding protein deletion on the susceptibility of Enterococcus faecium to cationic peptide antibiotics.  Antimicrob Agents Chemother 2015; 59(10):6132-9.  ABSTRACT  |  PDF
Science Translational Medicine Nizet V.  Stopping superbugs, maintaining the microbiota.  Sci Transl Med 2015; 7:295ed8.   PDF  |  Banner 
Infection & Immunity Xu D, Olson J, Cole JN, van Wijk XM, Brinkmann V, Zychlinsky A, Nizet V,  Esko JD, Chang YC.  Heparan sulfate modulates neutrophil and endothelial function in antibacterial innate immunity.  Infect Immun 2015; 83:3648-3656.  ABSTRACT  |  PDF
eBiomedicine Lin L, Nonejuie P, Munguia J, Hollands A, Olson J, Dam Q, Kumaraswamy M, Rivera H, Corriden R, Rohde M, Hensler ME, Burkart MD, Pogliano J, Sakoulas G,  Nizet V. Azithromycin synergizes with cationic antimicrobial peptides to exert bactericidal and therapeutic activity against highly multidrug-resistant Gram-negative bacterial pathogens. eBiomedicine 2015; 2:690–698. ABSTRACT  |  PDF  |  Supplemental  |  Commentary  |  Press Release  |  UT-San Diego  |  DDD Magazine
Chemistry & Biology Holden JK, Kang S, Beasley FC, Cinelli MA, Li H, Roy SG, Dejam D, Edinger AL, Nizet V, Silverman RB, Poulos TL.  Nitric oxide synthase as a target for methicillin-resistant Staphylococcus aureus.  Chem Biol 2015; 22;785–792.  ABSTRACT  |  PDF    
Antimicrobial Agents &
                Chemotherapy Hindler J, Wong-Beringer A, Charlton C, Campeau Miller S, Kelesidis T, Carvalho M, Sakoulas G, Nonejuie P, Pogliano J, Nizet V, Humphries R.  In vitro activity of daptomycin in combination with β-lactams, gentamicin, rifampin and tigecycline against daptomycin non-susceptible enterococci.  Antimicrob Agents Chemother 2015; 59:4279-8.   ABSTRACT  |  PDF
Journal of Molecular Medicine Kristian SA, Hwang JH,  Hall B, Liere E, Iacomini J, Old R, Galili U, Roberts C, Mullis KB, Westby M, Nizet V. Retargeting pre-existing human antibodies to a bacterial pathogen with an alpha-Gal conjugated aptamer.  J Mol Med 2015; 93:619-31.  ABSTRACT  |  PDF  |  SupplementalPress ReleaseDrug Dev News  |  Biocentury 
ChemBioChem Awakawa T, Crüsemann M, Munguia J, Ziemer N, Nizet V, Fenical W, Moore BS. Salinipyrone and pacificanone are biosynthetic byproducts of the rosamicin polyketide synthase. ChemBioChem 2015; 16:1443-7.   ABSTRACT  |  PDF  |  Supplemental 
PLoS Pathogens Lin AE, Beasley FC, Olson J, Keller N, Shalwitz RA, Hannan TJ, Hultgren SJ, Nizet V.  Hypoxia inducible factor-1α (HIF-1α) regulates host defense against urinary tract infection.  PLoS Pathog 2015; 11: e1004818.  ABSTRACT  |  PDF  |  Supplemental  |  Press Release  |  TIME Magazine
Infection & Immunity McEachern EK, Hwang JH, Sladewski KM, Nicatia S, Dewitz C, Mathew D, Nizet V, Crotty Alexander LE. Analysis of the effects of cigarette smoke on staphylococcal virulence phenotypes.  Infect Immun 2015; 83:2443-52.  ABSTRACT  |  PDF  |  Supplemental
PNAS Harbut MB, Vilcheze C, Luo X, Hensler ME, Guo H, Yang B, Chatterjee AK, Nizet V, Jacobs WR, Shultz PG, Wang F.  Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis.  Proc Natl Acad Sci USA 2015; 112:4453-8.   ABSTRACT  |  PDF  |  Supplemental
mBio Lin AE, Beasley FC, Keller N, Hollands A, Urbano R, Troemel ER, Hoffman HM, Nizet V. Group A Streptococcus ADP-ribosyltransferase toxin SpyA stimulates a protective IL-1β-dependent macrophage immune response. mBio 2015; 6:e00133-15   ABSTRACT  |  PDF  |  Supplemental 
Immunity Shalova IN, Lim JY, Chittezhath M, Zinkernagel AS, Beasley F, Hernández-Jiménez E, Toledano V, Rapsardi A, Chen J, Kaibo D, Yang H, Poidinger M, Melillo G, Nizet V, Arnalich F, Lopez-Collazo E, Biswas SK. Human monocytes undergo functional re-programming during sepsis mediated by hypoxia-inducible factor-1α.  Immunity 2015; 42:484-98.   ABSTRACT  |  PDF
Antimicrobial Agents and
                Chemotherapy Berti AD, Baines SL, Howden BP, Sakoulas G, Nizet V, Proctor RA, Rose WE.  Heterogeneity of genetic pathways toward daptomycin nonsusceptibility in Staphylococcus aureus determined by adjunctive antibiotics. Antimicrob Agents Chemother 2015; 59:2799 –806.   ABSTRACT  |  PDF 
BBA Biomembranes LaRock CN, Nizet V.  Cationic antimicrobial peptide resistance mechanisms of streptococcal pathogens. Biochem Biophys Acta 2015 1848:3047-54.  ABSTRACT  |  PDF 
Journal of Immunology Matak P, Heinis M, Mathieu JR, Corriden R, Delga S, Rouquette A, Mounier R, Raymond J, Lamarque D, Emile JF, Nizet V. Touati E, Peyssonnaux C.  Myeloid HIF-1 is protective in H. pylori-mediated gastritis.  J Immunol 2015; 194:3259-66.  ABSTRACT  |  PDF  |  Supplemental
Cell Host &
                Microbe Bier E, Nizet V.  Hedgehog: Linking uracil to innate defense.  Cell Host Microbe 2015; 17:146-158.  ABSTRACT  |  PDF
FEMS Microbiology Reviews Henningham A, Döhrmann S, Nizet V, Cole JN. Mechanisms of group A Streptococcus resistance to reactive oxygen species.  FEMS Microbiol Rev 2015; 39:488-508.  ABSTRACT  |  PDF 
Inflammasome Ali SR, Karin M, Nizet V. Signaling cascades and inflammasome activation in microbial infections. Inflammasome 2015; 2:7–12.  ABSTRACT  |  PDF  
FASEB Journal Patel V, Carrion K, Hollands A, Hinton A, Gallegos T, Dyo J, Sasik R, Leire E, Hardiman G, Mohamed SA, Nigam S, King CC, Nizet V, Nigam V. The stretch responsive microRNA miR-148a is a novel repressor of IκBkB,  NF-κB signaling, and inflammatory gene expression in human aortic valve cells.  FASEB J 2015; 29:1859-68.  ABSTRACT  |  PDF  |  Supplemental
Antimicrobial Agents and
                Chemotherapy Sakoulas G, Nonejuie P, Kullar R, Pogliano J, Rybak MJ, Nizet V.  Examining the use of ceftaroline in the treatment of Streptococcus pneumoniae meningitis with reference to human cathelicidin LL-37.  Antimicrob Agents Chemother 2015; 59:2428-31.  ABSTRACT  |  PDF 
Molecular Cell Wilkinson DS, Shah JS, Anderson E, Mitra K, Meisenhelder J, Chang JT, Ideker T, Hunter T, Nizet V, Dillin A, Hansen M. Phosphorylation of Hippo kinases STK3/STK4 is essential for autophagy.  Mol Cell 2015;  57:55-68.  ABSTRACT  |  PDF  |  Supplemental   
Remingtion & Klein Remington & Klein's Infectious Diseases of the Fetus & Newborn Infant, 8th Edition.  Wilson CB, Nizet V, Maldonado Y, Remington J, Klein JO.  Elsevier, Philadelphia. 2015  Chapters:  Current Concepts  |  Bacterial Sepsis & Meningitis  |  Focal Bacterial Infections  |  Group B Streptococcal Infections  |  Staphylococcal Infections
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Chemistry & Biology Gonzalez DJ, Corriden R, Akong-Moore K, Olson J, Dorrestein PC, Nizet V.  Functional properties of N-terminal ArgD peptides from the classical Staphylococcus aureus Agr system. Chem Biol 2014; 21:1457-1462.  ABSTRACT  |  PDF 
Immunity Palazon A, Goldrath A, Nizet V, Johnson RS.  HIF transcription factors, inflammation and immunity.  Immunity 2014; 41:518-528.  ABSTRACT  |  PDF 
European Journal of Medicinal
                Chemistry Kang S, Watanabe M, Jacobs JC, Yamaguchi M, Dahesh S, Nizet V, Leyh TS, Silverman RB.   Synthesis of mevalonate- and fluorinated mevalonate prodrugs and their in vitro human plasma stability. Eur J Med Chem 2014; 90C:448-461. ABSTRACT  |  PDF
Journal of Biological Henningham A, Yamaguchi M, Aziz RK, Kuipers K, Buffalo CZ, Dahesh S, Choudhury B, Van Vleet J, Yamaguchi Y, Seymour LM, Ben Zakour NL, He L, Smith HV, Grimwood K, Beatson SA, Ghosh P, Walker MJ, Nizet V, Cole JN. Mutual exclusivity of hyaluronan and hyaluronidase in invasive group A Streptococcus. J Biol Chem 2014;  2014, 289:32303-32315.  ABSTRACT  |  PDF
Biochemical Journal Neumann A, Berends ET, Nerlich A, Molhoek EM, Gallo RL, Meerloo T, Nizet V, Naim HY, von Köckritz-Blickwede M.  The antimicrobial peptide LL-37 facilitates the formation of neutrophil extracellular traps. Biochem J  2014;  464:3–11.   ABSTRACT  |  PDF
Journal of Molecular Medicine Vega VL, Crotty Alexander LE, Charles W, Nizet V, De Maio A. Activation of the stress response in macrophages alters the M1/M2 balance by enhancing bacterial killing and IL-10 expression.  J Mol Med 2014; 92:1305-1317.   ABSTRACT  |  PDF
Nature Reviews Microbiology Guichard A, Nizet V, Bier E.  Rab11-mediated trafficking in host-pathogen interactions.  Nat Rev Microbiol 2014; 12:624-634.  ABSTRACT  |  PDF
Infection & Immunity Döhrmann S, Anik S, Olson J, Anderson EL, Etesami N, No H, Snipper J, Nizet V, Okumura CY.  A role for streptococcal collagen-like protein 1 (Scl-1) in M1T1 group A Streptococcus resistance to neutrophil extracellular traps. Infect Immun 2014; 82:4011-4020.   ABSTRACT   |  PDF  |  Supplemental 
Journal of Biological Schommer NN, Muto J, Nizet V,  Gallo RL.  Hyaluronan breakdown contributes to immune defense against group A Streptococcus. J Biol Chem 2014; 289:26914-21.  ABSTRACT  |  PDF
ChemMedChem Fair RJ, McCoy LS, Hensler ME, Aguilar B, Nizet V, Tor Y.  Singly modified amikacin and tobramycin derivatives show increased rRNA A-site binding and higher potency against resistant bacteria. ChemMedChem 2014; 9:2164-71.   ABSTRACT  |  PDF  
Clinical Therapeutics Sakoulas G, Moise PA, Casapao AM, Nonejuie P, Olson J, Okumura CY, Rybak MJ, Kullar R, Dhand A, Rose WE, Goff DA, Bressler AM, Lee Y, Pogliano J, Johns S, Kaatz GW, Ebright JR, Nizet V.  Antimicrobial salvage therapy for persistent staphylococcal bacteremia using daptomycin plus ceftaroline. Clin Therap 2014; 36:1317–1333.   ABSTRACT  |  PDF 
Glycobiology Chang YC, Nizet V.  The interplay between Siglecs and sialylated pathogens. Glycobiology 2014; 24:818-825.  ABSTRACT   |  PDF
Journal of Innate Immunity Neumann A*, Völlger L*, Berends ET, Molhoek EM, Stapels DA, Midon M, Friães A, Pingoud A, Rooijakkers SM, Gallo RL, Mörgelin M, Nizet V, Naim HY,  von Köckritz-Blickwede M.   Novel role of the antimicrobial peptide LL-37 in the protection of neutrophil extracellular traps against degradation by bacterial nucleases.  J Innate Immun 2014;  6:860-868.  ABSTRACT  |  PDF 
Infectious DIseases and
                THerapy Bhandari T, Nizet V.  HIF as a pharmacological target for prevention and treatment of infectious diseases. Infect Dis Ther  2014; 3:159–174.  ABSTRACT  |  PDF 
Annual Reviews: Microbiology Okumura CYM, Nizet V. Subterfuge and sabotage: Evasion of host innate defenses by invasive Gram-positive bacterial pathogens.  Ann Rev Microbiol 2014; 68:439-58.   ABSTRACT  |  PDF 
Cell Host &
                Microbe van Sorge NM, Cole JN, Kuipers K, Henningham A, Aziz RK, Kasirer-Friede A, Lin L, Berends ETM, Davies MR, Dougan G, Zhang F, Dahesh S, Shaw L, Gin J, Cunningham M, Merriman JA, Hütter J, Lepenies B, Rooijakkers SHM, Malley R, Walker MJ, Shattil SJ, Schlievert PM, Choudhury B, Nizet V.  The classical Lancefield antigen of group A Streptococcus is a virulence determinant with implications for vaccine design.  Cell Host Microbe 2014; 15:729-740.  ABSTRACT   |   PDF   |  Graphical Abstract  |  Press Release (Standard)  |  Press Release (Purple Elf)
Journal of Experimental
                Medicine Ali SR, Fong J, Carlin AF, Busch TD, Linden R, Angata T, Areschoug T, Parast M, Varki N, Murray J, Nizet V, Varki A. Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus. J Exp Med 2014; 211:1231-1242.  ABSTRACT  |  PDF  | Press Release 
Journal of Molecular Medicine Chang YC, Olson J, Louie A, Crocker PR, Varki A, Nizet V.  Role of macrophage sialoadhesin in host defense against the sialylated pathogen group B StreptococcusJ Mol Med 2014; 92:951-9.   ABSTRACT  |  PDF  |  Supplemental
Journal of
                Antibiotics Hensler ME, Jang KH, Thienphrapa W, Vuong L, Tran DN, Soubih E, Lin L, Haste NM, Cunningham ML, Kwan B, Shaw KJ, Fenical W, Nizet V.  Anthracimycin activity against contemporary methicillin-resistant Staphylococcus aureusJ Antibiot 2014; 67:549-53.   ABSTRACT  |  PDF 
Clinical Microbiology Reviews Walker MJ, Barnett TC, McArthur JD, Cole JN, Gillen CM, Henningham A, Sriprakash KS, Sanderson-Smith ML, Nizet V. Disease manifestations and pathogenic mechanisms of group A Streptococcus. Clin Micro Rev 2014; 27:264-301.  ABSTRACT  |  PDF 
Molecular and Cellular
                Proteomics Gonzalez DJ, Vuong L, Gonzalez IS, Keller N, McGrosso D, Hwang HK, Hung J, Zinkernagel AS, Dixon JE, Dorrestein PC, Nizet V.  Phenol soluble modulin variants of community-associated methicillin-resistant Staphylococcus aureus captured using mass spectrometry-based molecular networking. Mol Cell Proteomics 2014; 13:1262-1272.  ABSTRACT  |  PDF  |  Supplemental
PNAS Tagliabracci VS, Engel JL, Wiley SE, Xiao J, Gonzalez DJ, Nidumanda Appaiah H, Nizet V, White KE, Dixon JE. Dynamic regulation of FGF23 by FAM20C phosphorylation, GALNT3 glycosylation and Furin proteolysis.  Proc Natl Acad Sci USA 2014; 111:5520-5525.  ABSTRACT  |  PDF
Journal of Clinical
                Microbiology Sakoulas G, Guram K, Reyes K, Nizet V, Zervos M.  Human cathelicidin LL-37 resistance and increased daptomycin MIC  in USA600 (ST45) methicillin-resistant Staphylococcus aureus is associated with increased mortality in a hospital setting.  J Clin Microbiol 2014; 52:2172-2174.  ABSTRACT  |  PDF  |  Supplemental   
Marine Drugs Liu Y, Haste NM, Thienphrapa W, Li J, Nizet V, Hensler M, Li R.  Marinopyrrole derivatives as potential antibiotic agents against methicillin-resistant Staphylococcus aureus (III). Marine Drugs 2014; 12:2458-2470.  ABSTRACT  |  PDF    
Antimicrobial Agents and
                Chemotherapy Sakoulas G, Rose W, Nonjuie P, Olson J, Pogliano J, Humphries R, Nizet V.  Ceftaroline restores daptomycin killing of daptomycin-nonsusceptible vancomycin-resistant Enterococcus faeciumAntimicrob Agents Chemother 2014; 58:1494-1500.  ABSTRACT  |  PDF  |  Supplemental
PLoS One Roupé KM, Veerla S, Olson J, Stone EL, Sørensen O, Hedrick SM, Nizet V. Transcription factor binding site analysis identifies FOXO transcription factors as regulators of the cutaneous wound healing process.  PLoS One 2014; 9: e89274.  ABSTRACT  |  PDF  |  Supplemental 
Journal of Infectious Diseases Randis TM, Gelber SE, Hooven TA, Abellar RG, Akabas LH, Lewis EL, Walker LB, Byland LM, Nizet V, Ratner AJ.  Group B Streptococcus β-hemolysin/cytolysin breaches maternal-fetal barriers to cause preterm birth and intrauterine fetal demise in vivoJ Infect Dis 2014; 210:265-73.   ABSTRACT  |  PDF 
PLoS One Opaluch AM, Schneider M, Chiang CY, Nguyen QT, Maestre AM, Mulder LC, Secundino I, De Jesus PD, König R, Simon V, Nizet V, MacLeod G, Varmuza S, Fernandez-Sesma A, Chanda SK.  Positive regulation of TRAF6-dependent innate immune responses by protein phosphatase PP1-γ.  PLoS One 2014 9: e89284  ABSTRACT  |  PDF  |  Supplemental 
Journal of Innate Immunity Askarian F, van Sorge NM, Sangvika M, Beasley FC, Henriksend JR, Sollida JU, van Strijp J, Nizet V, Johannessen M. Α Staphylococcus aureus TIR-domain protein virulence factor blocks TLR2-mediated NF-κB signaling.  J Innate Immun 2014; 6:485-98.   ABSTRACT  |  PDF  |  Supplemental 
Infection and Immunity Franks SE, Ebrahimi C, Hollands A, Okumura CY, Aroian RV, Nizet V, McGillivray SM.  A novel role for the yceGH tellurium resistance genes in the pathogenesis of Bacillus anthracisInfect Immun 2014; 82:1132-1140.  ABSTRACT  |  PDF 
Journal of Investigative Cowburn AS, Crotty Alexander LE, Nizet V, Chilvers ER, Johnson RS. Epidermal deletion of HIF-2α stimulates wound closure.  J Invest Derm 2014; 134: 801–808.  ABSTRACT  |  PDF |  Supplemental 
Journal of Innate Immunity Ly D, Taylor JM, Tsatsaronis JA, Monteleone MM, Skora AS, Donald CA, Maddocks T, Nizet V, West NP, Ranson M, Walker MJ, McArthur JD, Sanderson-Smith ML.  Plasmin(ogen) acquisition by group A Streptococcus protects against C3b-mediated neutrophil killing.  J Innate Immun 2014;6:240-50.  ABSTRACT  |  PDF  |  Supplemental 
Journal of Biological Anderson EL, Cole JN, Olson J, Ryba B, Ghosh P, Nizet V.  The fibrinogen-binding M1 protein reduces pharyngeal cell adherence and colonization phenotypes of M1T1 group A Streptococcus.  J Biol Chem 2014;  289:3539–3546.  ABSTRACT |  PDF 
FASEB Journal Padler-Karavani V, Hurtado-Ziola N, Chang YC, Sonnenburg JL, Ronaghy A, Yu H, Verhagen A, Nizet V, Chen X, Varki N, Varki A, Angata T.  Rapid evolution of binding specificities and expression patterns of inhibitory CD33-related Siglecs in primates.  FASEB J  2014; 28:1280-1293.  ABSTRACT  |  PDF 
PNAS Yamanaka K, Reynolds KA, Kersten RD, Ryan KS, Gonzalez DJ, Nizet V, Dorrestein PC, Moore BS.  Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A.  Proc Natl Acad Sci USA 2014; 111:1957-1962.   ABSTRACT  |  PDF  |  Supplemental  |  Press Release 
PLoS Pathogens Chang YC, Olson J, Beasley FC, Tung C, Zhang J, Crocker PR, Varki A, Nizet V.  Group B Streptococcus engages an inhibitory Siglec through sialic acid mimicry to blunt innate immune and inflammatory responses in vivoPLoS Pathogens 2014; 10: e1003846.  ABSTRACT  |  PDF  |  Supplemental 
Journal of Molecular Medicine Sakoulas G, Okumura CY,  Thienphrapa W, Olson J, Nonejuie P, Dam Q, Dhand A, Pogliano J, Yeaman MR, Hensler ME, Bayer AS,  Nizet V.  Nafcillin enhances innate immune-mediated killing of methicillin-resistant Staphylococcus aureusJ Mol Med 2014; 92:139-149.  ABSTRACT  |  PDFCommentary 
Journal of Infectious Diseases Lin AE, Autran CA, Española SD, Bode L, Nizet V.  Human milk oligosaccharides protect bladder epithelial cells against uropathogenic Escherichia coli invasion and cytotoxicity. J Infect Dis 2014; 209:389-398.  ABSTRACT   |  PDF  |  Supplemental  |  Nat Rev Urology 
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PLoS One Crotty Alexander L, Marsh B, Timmer A, Lin AE, Zainabadi K, Czopik A, Guarente L, Nizet V.  Myeloid cell SIRT1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection.  PLoS One 2013; 8: e84481.   ABSTRACT  |  PDF  |  Supplemental 
Cell Host &
                Microbe Barnett TC, Liebl D, Seymour LM, Gillen CM, Lim JY, LaRock CN, Davies MR, Shulz BL, Nizet V, Teasdale RD, Walker MJ.  The group A Streptococcus M1T1 clone evades autophagy for intracellular replication.  Cell Host Microbe 2013; 14:675-682 (cover article)   ABSTRACT  |  PDF  |  Supplemental  |  Commentary 
PNAS Grewal PK, Aziz PV, Uchiyama S, Rubio GR, Le D, Varki N, Nizet V, Marth JD. Inducing host protection in pneumococcal sepsis by pre-activation of the Ashwell-Morell receptor.  Proc Natl Acad Sci USA 2013; 110:20218-23   ABSTRACT  |  PDF  |  Supplemental  
Annals of Internal
                Medicine Fine AM, Nizet V, Mandl KD.  Participatory medicine: a home score for streptococcal pharyngitis enabled by real-time biosurveillance: a cohort study.  Ann Intern Med 2013; 159:577-583.  ABSTRACT  |  PDF  |  Commentary 1  |  Commentary 2 
PNAS Kersten RD, Ziemert N, Gonzalez DJ, Duggan BM, Nizet V, Dorrestein PC, Moore BS. Glycogenomics as a mass spectrometry guided genome mining method for microbial glycosylated molecules.  Proc Natl Acad Sci USA  2013; 110:E4407-16. ABSTRACT  |  PDF  |  Supplemental 
PLoS One Yamaguchi M, Terao Y, Mori-Yamaguchi Y, Domon H, Sakaue Y, Yagi T, Nishino K, Yamaguchi A, Nizet V, Kawabata S.  Streptococcus pneumoniae invades erythrocytes and utilizes them to evade human innate immunity.  PLoS One 2013; 8:e77282.  ABSTRACT  |  PDF
PNAS Cowburn AS, Takeda N, Boutin AT, Kim J-W, Sterling JC, Nakasaki M, Southwood M, Goldrath AW, Jamora C, Nizet V, Chilvers ER, Johnson RS.  HIF isoforms in the skin differentially regulate systemic arterial pressure.  Proc Natl Acad Sci USA 2013; 110:17570-17575.  ABSTRACT  |  PDF  |  Supplemental   
Cell Host &
                Microbe Guichard A, Cruz-Moreno B, Aguilar B, van Sorge NM, Kuang J, Kurkciyan AA, Wang Z, Hang S, Pineton de Chambrun GP, McCole DF, Watnick P, Nizet V, Bier E. Cholera toxin disrupts exocyst-mediated protein trafficking to intestinal epithelial cell junctions.  Cell Host Microbe 2013;14:294-305.  ABSTRACT  |  PDF  |  Supplemental  |  Commentary  |  Graphical Abstract  |  Press Release 
Meningitis - CABI Nizet V, Doran K.  Group B Streptococcal Meningitis. In: "Meningitis: Cellular and Molecular Basis" (M. Christodoulides, ed.), CABI, London, 2013, pp.  118-132.   PDF
Nature Nizet V, Yaksh T.  Neuroscience: Bacteria get on your nerves.  Nature 2013; 501:43-44.  PDF  |  SciBx
Journal of
                Inflammation Leire E, Olson J, Isaacs H, Nizet V, Hollands A.  Role of hypoxia inducible factor-1 in keratinocyte inflammatory response and neutrophil recruitment.  J Inflamm 2013; 10:28  ABSTRACT   |  PDF 
mBio Okumura CY, Anderson EL, Döhrmann S, Tran DN, Olson J, von Pawel-Rammingen U, Nizet V.  IgG protease Mac/IdeS is not essential for phagocyte resistance or mouse virulence of M1T1 group A StreptococcusmBio 2013; 4:3e0049-13.  ABSTRACT  |  PDF 
Antimicrobial Agents and
                Chemotherapy Berti AE, Sakoulas G, Nizet V, Tewhey R, Rose WE.  β-lactam antibiotics targeting PBP1 selectively enhance daptomycin activity against methicillin-resistant Staphylococcus aureusAntimicrob Agents Chemother 2013; 57:5005-5012.  ABSTRACT   |  PDF 
Biochemical Journal Sjögren J, Struwe W, Cosgrave E, Rudd P, Stervander M, Allhorn M, Hollands A, Nizet V, Collin M. EndoS2 is a unique and conserved protein of serotype M49 group A Streptococcus that hydrolyzes N-linked glycans on IgG and α1-acid glycoprotein.  Biochem J 2013; 455:107-118.  ABSTRACT  |  PDF  |  Supplemental 
PLoS Pathogens Sanderson-Smith ML, Zhang Y, Ly D, Donahue D, Hollands A, Nizet V, Ploplis VA, Walker MJ, Castellino FJ.  A key role for the urokinase plasminogen activator (uPA) in invasive group A streptococcal infection. PLoS Pathogens 2013; 9:e1003469  ABSTRACT  |  PDF  |  Supplemental 
EMBO Reports Corriden R, Self T, Akong-Moore K, Nizet V, Kellam B, Briddon S, Hill S.  Human neutrophil A3-adenosine receptor microdomains promote bacteria-tethering cytoneme formation.  EMBO Reports  2013; 14:726-732.  ABSTRACT  |  PDF  |  Supplemental  |  Video S1  |  Video S2  |  Video S3 
Journal of Molecular Medicine Bhandari T, Olson J, Johnson RS, Nizet V.  HIF-1α influences myeloid cell antigen presentation and response to subcutaneous OVA vaccination.  J Mol Med 2013; 91:1199-1205.  ABSTRACT  |  PDF 
Antimicrobial Agents &
                Chemotherapy Sakoulas G, Nonejuie P, Nizet V, Pogliano J, Crum-Ciaflone N, Haddad F.  Treatment of recurrent high-level gentamicin-resistant Enterococcus faecalis endocarditis with daptomycin plus ceftaroline. Antimicrob Agents Chemother 2013; 57: 4042-4045.  ABSTRACT  |  PDF
Journal Clinical Microbiology Jantsch J, Gerlach R, Ensser A, Dahesh S, Popp I, Heeg C, Bleiziffer O, Merz T, Schulz T, Horch R, Bogdan C, Nizet V,  Van Der Linden M. Severe soft tissue infection caused by a non-β-hemolytic Streptococcus pyogenes strain harboring a premature stop mutation in the sagC gene.  J Clin Microbiol 2013; 51:1962–1965.  ABSTRACT |  PDF
Infection and Immunity Venturini C, Ong CY, Gillen CM, Ben-Zakour N, Maamary PG, Nizet V, Beatson SA, Walker MJ.  Enhanced virulence through Acquisition of Sda1-encoding bacteriophage does not enhance virulence of the M1 Streptococcus pyogenes strain SF370.  Infect Immun 2013; 81:2062-2069.   ABSTRACT  |  PDF
FASEB Journal Tsatsaronis J, Hollands A, Cole JN, Maamary PG, McArthur JD, Ben Zakour N, Kotb M, Nizet V, Beatson S, Walker MJ, Sanderson-Smith ML.  Streptococcal collagen-like protein A and general stress protein 24 are immuno-modulating virulence factors of group A Streptococcus. FASEB J 2013; 27:2633-43.   ABSTRACT  |  PDF  |  Supplemental
Nature Tannahill GM, Curtis AM, Adamik J, Palsson-McDermott EM,  McGettrick AF,  Goel G, Frezza C, Bernard NJ, Kelly B, Foley NH, Zheng L, Gardet A, Tong Z, Jany SS, Corr SC, Clish C, Haneklaus M,  Caffrey BE, Pierce K, Walmsley S, Beasley FC, Cummins E, Nizet V, Whyte M, Taylor CT, Lin H, Masters SL, Gottlieb E, Kelly VP, Clish C, Auron PE, Xavier RJ, O’Neill LAJ.  Succinate is an inflammatory signal that induces IL-1β transcription through HIF-1α.  Nature 2013; 496:238-242.  ABSTRACT  |  PDF  |  Supplemental 
Cellular & Molecular Life Science Angata T, Ishii T, Motegi T, Oka R, Taylor RE, Campos-Soto P, Chang YC, Secundino I, Gao CX, Ohtsubo K,  Kitazume S, Nizet V, Varki A, Gemma A, Kida K, Taniguchi N. Loss of Siglec-14 reduces the risk of chronic obstructive pulmonary disease exacerbation.  Cell Mol Life Sci 2013; 70:3199-3210.  ABSTRACT  |  PDF
Journal of Molecular Medicine Uchiyama S, Andreoni F, Zürcher C, Schilcher K, Ender M, Madon J, Matt U, Ghosh P, Nizet V, Scheupbach RA, Zinkernagel AS.  Coiled-coil irregularities of the M1 protein structure promote M1-fibrinogen interaction and influence group A Streptococcus host cell interactions and virulence.  J Mol Med 2013; 91:861-869.  ABSTRACT  |  PDF  | Supplemental
Clinical Immunology Baek KJ, Cho JY, Rosenthal P, Crotty Alexander LE, Nizet V, Broide DH.  Hypoxia potentiates allergen induction of HIF-1α, chemokines, airway inflammation, TGF-β1, and airway remodeling in a mouse model.  Clin Immunol 2013; 147:27-37.  ABSTRACT  |  PDF
Journal of Biological van Sorge NM, Beasley FC, Gusarov I, Gonzalez DJ, von Köckritz-Blickwede M, Anik S, Borkowski A, Dorrestein PC, Nudler E, Nizet V. Methicillin-resistant Staphylococcus aureus bacterial nitric oxide synthase affects antibiotic sensitivity and skin abscess development.  J Biol Chem 2013; 288:6417-6426.  ABSTRACT   |  PDF  |  Supplemental 
PNAS Zhu W, Zhang Y, Sinko W, Hensler ME, Olson J, Molohon KJ, Lindert S, Cao R, Li K, Wang K, Wang Y, Liu YL, Sankovsky A, de Oliveira CA, Mitchell DA, Nizet V, McCammon JA, Oldfield E. Antibacterial drug leads targeting isoprenoid biosynthesis.  Proc Natl Acad Sci 2013; 110:123-125.   ABSTRACT PDF 
Journal of Molecular Medicine Crotty Alexander LE, Akong-Moore K, Feldstein S, Johansson P, Nguyen A, McEachern EK, Nicatia S, Cowburn AS, Olson J, Cho JY, Isaacs H, Johnson RS, Broide DH, Nizet V.  Myeloid cell HIF-1α regulates asthma airway resistance and eosinophil function.  J Mol Med 2013; 91:637-44  ABSTRACT  |  PDF 
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Journal of Biological
                Chemsitry Hollands A, Gonzalez DJ, Leire E, Donald C, Gallo RL, Sanderson-Smith M, Dorrestein PC, Nizet V.  A bacterial pathogens co-opts host plasmin to resist killing by cathelicidin antimicrobial peptides. J Biol Chem 2012; 287: 40891-40897.  ABSTRACTPDF
PLoS Genetics Kuang E, Okumura CY, Sheffy-Levin S, Varzano T, Shu VC, Qi J, Niesman IR, Olson J, Reed JC, Broday L, Nizet V, Ronai ZA.  Regulation of ATG4B stability by RNF5 limits basal levels of autophagy and influences susceptibility to bacterial infection.  PLoS Genetics 2012; 8(10):e1003007.  ABSTRACT  |  PDF 
Journal of
                Antibiotics Haste NM, Thienphrapa W, Tran DN, Loesgen S, Sun P, Nam SJ, Jensen PR, Fenical W, Sakoulas G, Nizet V, Hensler ME. Activity of the thiopeptide antibiotic nosiheptide against contemporary strains of methicillin-resistant Staphylococcus aureus J Antibiotics 2012; 65: 593-598.  ABSTRACT  |  PDF
Journal of Infectious Diseases Rose WE, Eickhoff JC, Shukla SK, Pantarangi M, Rooijakkers SH, Cosgrove SE, Nizet V, Sakoulas G.  Elevated serum interleukin-10 (IL-10) at time of hospital admission is predictive of mortality in patients with Staphylococcus aureus bacteremia. J Infect Dis 2012; 206:1604-1611.  ABSTRACT  |  PDF   |  Supplemental
Antimicrobial Agents &
                Chemotherapy Humphries RM, Kelesidis T, Tewhey R, Rose W, Schork N, Nizet V, Sakoulas G.  Genotypic and phenotypic evaluation of the evolution of high-level daptomycin non-susceptibility in vancomycin-resistant Enterococcus faecium. Antimicrob Agents Chemother 2012; 56:6051-3.  ABSTRACT  |  PDF 
Journal of Bacteriology Cole JN, Aziz RK, Kuipers K, Timmer AM, Nizet V, van Sorge NM.  A conserved UDP-glucose dehydrogenase outside the hasABC operon contributes to capsule biogenesis in group A Streptococcus. J Bacteriol 2012; 194:6154-61.  ABSTRACT  |  PDF
Virulence Dahesh S, Nizet V, Cole JN.  Study of streptococcal hemoprotein receptor (Shr) in iron acquisition and virulence of M1T1 group A StreptococcusVirulence 2012; 3:566-575.  ABSTRACT  |  PDF  |  Commentary  
PPPID, 4th Edition Arnold JC, Nizet V. Pharyngitis. In: Principles and Practices of Pediatric Infectious Diseases, 4th Edition (S Long, LK Pickering, CG Prober, eds.). Elsevier, Philadelphia, Chapter 27, pp. 199-205. 2012.  PDF
PPPID, 4th Edition Nizet V, Arnold JC. Streptococcus pyogenes (Group A Streptococcus). In: Principles and Practices of Pediatric Infectious Diseases, 4th Edition (S Long, LK Pickering, CG Prober, eds.). Elsevier, Philadelphia, Chapter 118, pp. 698-707.  2012.  PDF
FASEB Journal Maamary PG, Ben Zakour NL, Cole JN, Hollands A, Barnett TC, Cork AJ, Henningham A, Sanderson-Smith M, McArthur JD, Venturini C, Gillen CM, Kirk JK, Johnson DR, Aziz RK, Taylor WL, Kaplan EL, Kotb M, Nizet V, Beatson SA, Walker MJ.  Evolution and selection for the pandemic group A streptococcal M1T1 clone.  FASEB J 2012; 26:4675-84.   ABSTRACT  |  PDF
PLoS One Akong-Moore K, Chow OA, von Köckritz-Blickwede M, Nizet V.  Influences of chloride and hypochlorite on neutrophil extracellular extracellular trap formation.  PLoS One 2012 7:e42984.  ABSTRACT  |  PDF  
Biochemical Journal Branitzki-Heinemann K, Okumura CY, Völlger L, Kawakami Y, Kawakami T, Naim HY, Nizet V, von Köckritz-Blickwede M.  Novel role of the transcription factor HIF-1α in the formation of mast cell extracellular traps.  Biochem J 2012; 446:159-163.  ABSTRACT  |  PDF
PLoS Pathogens
Bebien M, Hensler ME, Hsu LC, Karin M, Park JM, Alexopoulou L, Liu GY, Nizet V, Lawrence T.  The pore-forming toxin ß-hemolysin/cytolysin triggers p38 MAPK-dependent IL-10 production in macrophages and inhibits innate immunity.  PLoS Pathogens 2012; 8:e1002812 ABSTRACT  |  PDF 
Journal of Proteomics Gonzalez DJ, Xu Y, Yang YL, Esquenazi E, Liu WT, Edlund A, Duong T, Du L, Molnár I, Gerwick WH, Jensen PR, Fischbach M, Liaw CC, Straight P, Nizet V, Dorrestein PC.  Observing the invisible through imaging mass spectrometry, a window into the metabolic exchange patterns of microbes. J Proteomics 2012; 75:5069-5076.   ABSTRACT  |  PDF  |  Supplemental 
PLoS Pathogens Uchiyama S, Andreoni F, Schüpbach RA, Nizet V, Zinkernagel AS.  DNase Sda1 allows invasive M1T1 group A Streptococcus to prevent TLR9 recognition.  PLoS Pathogens 2012; 8:e1002736  ABSTRACT  |  PDF  |  Supplemental 
PNAS Wang X, Mitra N, Secundino-Velasquez I, Banda K, Cruz P, Padler-Karavani V, Verhagen A, Reid C, Lari M, Rizzi E, Balsamo C, Corti G, De Bellis G, Longo L, NISC Comparative Sequencing Program, Beggs W, Caramelli D, Tishkoff S, Hayakawa T, Green ED, Mulliken JC, Nizet V, Bui JD, Varki A.  Specific inactivation of two immunomodulatory SIGLEC genes during human evolution.  Proc Natl Acad Sci USA 2012; 109:9935-9940. ABSTRACT PDF  |  Supplemental  |  Press Release 
ChemMedChem Fair RJ, Hensler ME, Thienphrapa W, Dam QN, Nizet V, Tor Y.  Selectively guanidinylated aminoglycosides as antibiotics.  ChemMedChem 2012; 7:1237-1244. ABSTRACT   |  PDF  |  Supplemental 
Chemistry & Biology van der Westhuyzen R, Hammons J, Meier J, Dahesh S, Moolman W, Pelley S, Nizet V, Burkart M, Strauss E.  The antibiotic CJ-15,801 is an antimetabolite which hijacks and then inhibits CoA biosynthesis.  Chem Biol 2012; 19:559-571 (Cover article). ABSTRACT  |  PDF  |  Commentary 
Archives of Internal
                Medicine Fine AM, Nizet V, Mandl KD. Large-scale validation of the Centor and McIsaac scores to predict group A streptococcal pharyngitis.  Arch Intern Med 2012; 172:847-852.  ABSTRACT  |  PDF + Commentary    
Genes &
                Development Sano R, Hou YC, Hedvat M, Correa RG, Shu CW, Krajewska M, Diaz PW, Quarato G, Gottlieb RA, Yamaguchi M,  Nizet V, Dahl R, Thomas DD, Tait SW, Green DR, Fisher PB, Matsuzawa SI, Reed JC.  Endoplasmic Reticulum Protein BI-1 regulates Ca2+-mediated bioenergetics to promote autophagy.  Genes Dev 2012; 26:1041-54.  ABSTRACT  |  PDF  |  Supplemental 
Journal of Biological
                Chemistry Gonzalez DJ, Okumura CY, Hollands A, Kersten R, Akong-Moore K, Pence MA, Malone CL, Derieux J, Moore BS, Horswill, AR, Dixon JE, Dorrestein PC, Nizet V. Novel phenol soluble modulin derivatives in community-associated methicillin-resistant Staphylococcus aureus identified through imaging mass spectrometry.  J Biol Chem 2012; 287:13889-13898.  ABSTRACT  |  PDF  |  Supplemental     
Marine Drugs Liu Y, Haste NM, Thienphrapa W, Nizet V, Hensler ME, Li R.  Marinopyrrole derivatives as potential antibiotic agents against methicillin-resistant Staphylococcus aureusMarine Drugs 2012; 10:953-962.  ABSTRACT  |  PDF
Journal of Molecular Medicine Henningham A, Chiarot E, Gillen CM, Cole JN, Rohde M, Fulde M, Ramachandran V, Cork AJ, Hartas J, Magor G,  Djordjevic SP, Cordwell SJ, Kobe B, Sriprakash KS, Nizet V, Chhatwal GS, Batzloff MR, Margarit IR, Walker MJ.  Conserved anchorless surface proteins as group A streptococcal vaccine candidates. J Mol Med 2012; 90:1197-1207.  ABSTRACT  |  PDF  |  Supplemental
ACS Medicinal Chemistry
                Letters Zhang Y, Lin FY, Li K, Zhu W, Liu YL, Cao R, Pang R, Lee E, Axelson J, Hensler ME, Wang K, Molohon K, Mitchell D, Nizet V, Oldfield E.  HIV integrase inhibitor-inspired antibacterials targeting isoprenoid biosynthesis.  ACS Med Chem Lett 2012; 3:402-406.  ABSTRACT  |  PDF  |  Supplemental  
PLoS One Hertzén E, Johansson L, Kansal R, Hecht A, Dahesh S, Marton J, Nizet V, Kotb M, Norrby-Teglund A.  Intracellular Streptococcus pyogenes in human macrophages display an altered gene expression profile.  PLoS One 2012; 7:e35218. ABSTRACT  |  PDF 
Antimicrobial Agents and
                Chemotherapy McGillivray SM, Tran DN, Ramadoss NS, Alumasa JN, Okumura CY, Sakoulas G, Vaughn MM, Zhang DX, Keiler KC, Nizet V. Pharmacological inhibition of the ClpXP protease increases bacterial susceptibility to host cathelicidin antimicrobial peptides and cell-envelope active antibiotics.  Antimicrob Agents Chemother 2012; 56:1854-1861.  ABSTRACT  |  PDF  
Cell Host and Microbe Chiang CY, Engel A, Opaluch AM, Ramos I, Maestre AM, Secundino I, De Jesus PD, Nguyen QT, Welch G, Bonamy GM, Miraglia LJ, Orth AP, Nizet V, Fernandez-Sesma A, Zhou Y, Barton GM, Chanda SK.  Co-factors required for TLR7 and TLR9- dependent innate immune responses.  Cell Host Microbe 2012; 11:306-318.  ABSTRACT  |  PDF  |  Supplemental  |  Graphic
Journal of Molecular Medicine Okumura CYM, Hollands A, Tran DN, Olson J, Dahesh S, von Köckritz-Blickwede M, Thienphrapa W, Corle C, Jeung SN, Kotsakis A, Shalwitz RA, Johnson RS, Nizet V. A new pharmacological agent (AKB-4924) stabilizes hypoxia inducible factor (HIF) and increases skin innate defenses against bacterial infection.  J Mol Med 2012; 90:1079-1089.   ABSTRACT  |  PDF
Journal of Innate Immunity Jongerius I, von Köckritz-Blickwede M, Horsburgh MJ, Ruyken M, Nizet V, Rooijakkers SH.  Staphylococcus aureus virulence is enhanced by secreted factors that block innate immune defenses.  J Innate Immun 2012; 4:301-311.   ABSTRACT  |  PDF  |  Supplemental 
ChemMedChem Lin FY, Zhang Y, Hensler ME, Liu YL, Chow OA, Zhu W, Wang K, Pan R, Thienphrapa W, Nizet V, Oldfield E.  Dual dehydrosqualene synthase/squalene synthase inhibitors: Leads for innate immune system based therapeutics.  ChemMedChem 2012; 7:561-564.   ABSTRACT  |  PDF 
Antimicrobial Agents and
                Chemotherapy Sakoulas G, Bayer AS, Pogliano J, Tsuji BT, Yang SJ, Mishra NN, Nizet V, Yeaman MR, Moise PA.  Ampicillin enhances daptomycin- and cationic host defense peptide-mediated killing of ampicillin- and vancomycin-resistant Enterococcus faeciumAntimicrob Agents Chemother 2012; 56:838-844.  ABSTRACT  |  PDF  
PLoS One Sakoulas G, Nam S-J, Loesgen S, Fenical W, Jensen PR, Nizet V, Hensler M. Novel bacterial metabolite merochlorin A demonstrates activity against multi-drug resistant methicillin-resistant Staphylococcus aureusPLoS One 2012; 7:e29439.   ABSTRACT  |  PDF 
mBio Chang YC, Uchiyama S, Varki A, Nizet V.  Leukocyte inflammatory responses provoked by pneumococcal sialidase.  mBio 2012; 3:e00220-11.  ABSTRACT  |  PDF  
Microbes &
                Infection Guichard A, Nizet V, Bier E.  New insights into the biological effects of anthrax toxins: linking cellular to organismal responses.  Microb Infect 2012; 14:97-118.  ABSTRACT  |  PDF
Developmental & Comparative
                Immunology Carland TM, Locke JB, Nizet V, Gerwick L.  Differential expression and intrachromosomal evolution of the sghC1q genes in zebrafish (Danio rerio).  Dev Comp Immunol 2012; 36:31-38.  ABSTRACT  |  PDF
Journal of Innate Immunity Zinkernagel AS, Hruz P, Uchiyama S, von Köckritz-Blickwede M, Schuepbach RA, Hayashi T, Carson DA, Nizet V.  Importance of Toll-like receptor 9 in host defense against M1T1 group A Streptococcus infections. J Innate Immun 2012; 4:213-218. ABSTRACT  |  PDF  |  Supplemental 
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PLoS One Kho MF, Bellier A, Balasubramini V, Hu Y, Hsu W, Nielsen-LeRoux C, McGillivray SM, Nizet V, Aroian RV. The pore-forming protein Cry5B elicits the pathogenicity of Bacillus sp. against Caenorhabditis elegans. PLoS One 2011; 6: e29122.  ABSTRACT  |  PDF 
Journal of Biological
                Chemistry Nordström T, Movert E, Olin A, Ali SR, Nizet V, Varki A, Areschoug T.  Human Siglec-5 inhibitory receptor and immunoglobulin A (IgA) have separate binding sites in streptococcal β protein. J Biol Chem 2011; 286:33981-33991.  ABSTRACT  |  PDF  |  Supplemental 
Annals of Internal
                Medicine Fine AM, Nizet V, Mandl KD.  Improved diagnostic accuracy of group A streptococcal pharyngitis with use of real-time biosurveillance.  Ann Intern_Med 2011; 155:345-352.  ABSTRACT  |  PDF  |  Press Release 
Nature Reviews Microbiology Cole JN, Barnett TC, Nizet V, Walker MJ. Molecular insight into group A streptococcal invasive disease.  Nat Rev Microbiol 2011; 9:724-736.  ABSTRACT  |  PDF 
Nature Immunology Kinjo Y, Illarionov P, Vela JL, Pei B, Girardi E, Li X, Li Y, Imamura M, Kaneko Y, Okawara A, Miyazaki Y, Gómez-Velasco A, Rogers P, Dahesh S, Uchiyama S, Khurana A, Kawahara K, Yesilkaya H, Andrew PW, Wong CH, Kawakami K, Nizet V, Besra GS, Tsuji M, Zajonc DM, Kronenberg M. Invariant NKT cells recognize glycolipids from pathogenic Gram-positive bacteria.  Nat Immunol 2011; 12:966-974.  ABSTRACT  |  PDF Supplemental 
Bioorganic & Medicine
                Chemistry Sun P, Maloney KN, Nam SJ, Haste NM, Raju R, Aalsbersberg W, Jensen PR, Nizet V, Hensler ME, Fenical W.  Fijimycins A-C, three antibacterial etamycin-class depsipeptides from a marine-derived Streptomyces sp.  Bioorg Med Chem 2011; 19:6557-6662.  ABSTRACT  |  PDF
Microbiology Gonzalez DJ, Haste NM, Hollands A, Fleming T, Hambya M, Pogliano K, Nizet V, Dorrestein PC.  Microbial competition between Bacillus subtilis and Staphylococcus aureus monitored by imaging mass spectrometry.  Microbiology 2011; 57:2485–2492. ABSTRACTPDF  |  Supplemental
BMC Microbiology Sjögren J, Okumura CY, Collin M, Nizet V, Hollands A.  Study of the IgG endoglycosidase EndoS in group A streptococcal phagocyte resistance and virulence.  BMC Microbiol 2011; 11:120.   ABSTRACT  |  PDF  
PLoS Pathogens Chang YC, Wang Z, Flax LA, Xu D, Esko JD Nizet V, Baron MJ.  Glycosaminoglycan binding facilitates entry of a bacterial pathogen into central nervous systems.  PLoS Pathogens 2011; 7:e1002082  ABSTRACT  |  PDF  |  Supplemental
Clinical Infectious Diseases Dhand A, Bayer AS, Pogliano J, Yang SJ, Bolaris M, Nizet V, Wang G, Sakoulas G.  Use of antistaphylococcal β-lactams to increase daptomycin activity in eradicating persistent bacteremia due to methicillin-resistant Staphylococcus aureus: role of enhanced daptomycin binding. Clin Infect Dis 2011; 53: 158-163.  ABSTRACT  |  PDF
Immunity Ali SR, Timmer AM, Bilgrami S, Park EJ, Eckmann L, Nizet V, Karin M. Anthrax toxin induces macrophage death by p38 MAPK inhibition but leads to inflammasome activation via ATP leakage.  Immunity 2011; 35:34-44.   ABSTRACT PDF  |  Supplemental  |  Press Release
Antimicrobial Agents &
                Chemotherapy Haste NM, Hughes CC, Tran DN, Fenical W, Jensen PR, Nizet V, Hensler ME.  Pharmacological properties of the marine natural product marinopyrrole A against methicillin-resistant Staphylococcus aureusAntimicrob Agents Chemother 2011; 55:3305-3312. ABSTRACT  |  PDF 
                Microbiology Amelung S, Nerlick A, Rohde M, Spellerberg B, Cole JN, Nizet V, Chhatwal GS, Talay SR. The FbaB-type fibronectin-binding protein of Streptococcus pyogenes promotes specific invasion into endothelial cells.  Cell Microbiol 2011; 13:1200-1211.  ABSTRACT  |  PDF
Marine Drugs Haste NM, Farnaes L, Perera VR, Fenical W, Nizet V, Hensler ME.  Bactericidal kinetics of marine-derived napyradiomycins against contemporary methicillin-resistant Staphylococcus aureusMarine Drugs 2011; 9:680-689.  ABSTRACT  |  PDF 
Journal of Molecular Medicine Kisseleva T, von Köckritz-Blickwede M, Reichart D, McGillvray SM, Wingender G, Kronenberg M, Glass CK, Nizet V, Brenner DA. Fibrocyte-like cells recruited to the spleen support innate and adaptive immune responses to acute injury or infection.  J Mol Med 2011; 89:997-1013.  ABSTRACT  |  PDF  |  Supplemental 
Nature Macheboeuf P, Buffalo C, Fu CY, Zinkernagel AS, Cole JN, Johnson JE, Nizet V, Ghosh P.  Streptococcal M1 protein constructs a pathological host fibrinogen network.  Nature 2011; 472:64-68.  ABSTRACT  |  PDF  |  Supplemental  |  Movie Press Release  
Molecular Microbiology Yang H, Sikavi C, Tran K, McGillivray SM, Nizet V, Yung M, Chang A, Miller JH.  Papillation in Bacillus anthracis colonies: a tool for finding new mutators.  Mol Microbiol  2011; 79:1276-1293.  ABSTRACT  |  PDF 
Journal of Infectious Diseases Reiß A, Braun JS, Jäger K, Freyer D, Laube G, Bührer C, Felderhoff-Müser U, Nizet V, Weber JR.  Bacterial pore-forming cytolysins induce neuronal damage in a rat model of neonatal meningitis.  J Infect Dis 2011; 3:393-400.   ABSTRACT  |  PDF
Nature Immunology Hsu LC, Enzler T, Seita J, Timmer AM, Lee CY, Lai TY, Yu GY, Lai LC, Temkin V, Nizet V, Weissman IL, Karin M. IL-1β-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKβNat Immunol 2011; 12:144-50. ABSTRACT  |  PDF  |  Supplemental  | Press ReleaseRussian Podcast 
Remington & Klein Nizet V, Bradley JS. Staphylococcal infections. In: Infectious Diseases of the Fetus and Newborn Infant, 7th Edition.  (J Remington, JO Klein, CB Wilson, V. Nizet, B. Maldonado, eds.) Elsevier, Philadelphia, p. 489-515, 2011.  PDF
Remington & Klein Edwards MS, Nizet V, Baker CJ. Group B streptococcal infections.  In: Infectious Diseases of the Fetus and Newborn Infant, 7th Edition (J Remington, JO Klein, CB Wilson, V. Nizet, B. Maldonado, eds.) Elsevier, Philadelphia, p. 419-469, 2011.  PDF
Remington & Klein Nizet V, Klein JO.  Bacterial sepsis and meningitis. In: Infectious Diseases of the Fetus and Newborn Infant, 7th Edition.  (J Remington, JO Klein, CB Wilson, V. Nizet, B. Maldonado, eds.) Elsevier, Philadelphia, p. 222-275, 2011.  PDF
Tetrahedron Letters Nicolaou KC, Simmons NL, Chen JS, Haste NM, Nizet V.  Total synthesis and biological evaluation of marinopyrrole A and analogs.  Tetrahed Lett  2011; 52:2041-2043.  ABSTRACT  |  PDF
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Cell Host &
                Microbe Chow OA, von Köckritz-Blickwede M, Bright AT, Hensler ME, Zinkernagel AS, Cogen AL, Gallo RL, Monestier M, Wang Y, Glass CK, Nizet V.  Statins enhance formation of phagocyte extracellular traps.  Cell Host Microbe 2010; 8:445-454.   ABSTRACT  |  PDF  |  Supplemental  |  Press Release
Nature Guichard A, McGillivray SM, Moreno BC, van Sorge NM, Nizet V, Bier E.  Anthrax toxins cooperatively inhibit endocytic recycling by the Rab11/Sec15 exocyst.  Nature 2010; 467:854-858.  ABSTRACT  |  PDF  |  Supplemental  |  Press Release  |  Analizy i Komentarze
Immunology of Infection von Köckritz-Blickwede M, Chow O, Ghochani M, Nizet V.  Visualization and functional evaluation of phagocyte extracellular traps. In: Methods in Microbiology (Volume 37) Immunology of Infection, 3rd Edition (D Kabelitz and SH Kaufmann, eds). Academic Press, London, p. 139-160, 2010.  PDF 
Journal of Innate Immunity Nizet V.  Bacteria and phagocytes: Mortal enemies.  J Innate Immun 2010; 2:505-507.  PDF
Journal of Innate Immunity Berends ET, Horswill AR, Haste NM, Nizet V, von Köckritz-Blickwede M. Nuclease expression by Staphylococcus aureus facilitates escape from neutrophil extracellular traps.  J Innate Immun 2010; 2:576-586.  ABSTRACT  |  PDF  |  Supplemental
mBio Cole JN, Pence MA, von Köckritz-Blickwede M, Hollands A, Gallo RL, Walker MJ, Nizet V.  M protein and hyaluronic acid capsule are essential for in vivo selection of covR/S mutations characteristic of invasive M1T1 group A Streptococcus.  MBio 2010; 1: e00191-10ABSTRACT  |  PDF
Journal of Innate Immunity Maamary P, Sanderson-Smith M, Aziz R, Hollands A, McKay F, Cole J,  McArthur J,  Kirk J, Cork A, Keefe R, Kansal R, Sun H, Taylor W, Chhatwal C, Ginsburg D, Nizet V, Kotb M, Walker MJ. Parameters governing invasive disease propensity of non-M1 serotype group A streptococci.  J Innate Immun 2010; 2:596-606  ABSTRACT  |  PDF  |  Supplemental
Journal of Innate Immunity Pence MA, Rooijakkers SH, Cogen AL, Cole JN, Hollands A, Gallo RL, Nizet V.  Streptococcal inhibitor of complement (SIC) promotes innate immune resistance phenotypes of invasive M1T1 group A StreptococcusJ Innate Immun 2010; 2:587-595. ABSTRACT  |  PDF  |  Supplemental
PNAS Liu WT, Yang YL, Xu Y, Lamsa A, Haste NM, Yang JY, Ng J, Gonzalez DJ, Ellermeier CD, Straight PD, Pevzner P, Pogliano J, Nizet V, Pogliano K, Dorrestein PC.  Imaging mass spectrometry of intraspecies metabolic exchange revealed the cannibalistic factors of Bacillus subtilis.  Proc Natl Acad Sci USA  2010; 107:16286-16290.  ABSTRACT  |  PDF  |  Supplemental Movie
BMCL Derbal S, Hensler M, Fang W, Nizet V, Ghedira K, Nefzi A.  On resin amino acid side chain attachment strategy for the head to tail synthesis of new glutamine containing gramicidin-S analogs and their antimicrobial activity.  Bioorg Med Chem Lett 2010; 20:5701-5704.  ABSTRACT  |  PDF  
PLoS One Zhao HW, Zhou D, Nizet V, Haddad GG.  Experimental selection for Drosophila survival in extremely high O2 environmentsPLoS One 2010; 5:e11701.   ABSTRACT  |  PDF
J Exp Med Taylor RE, Gregg C, Padler-Karavani V, Ghaderi D, Yu H, Sorensen RU, Chen X, Inostroza J, Nizet V, Varki A.   Novel mechanism for the generation of human xeno-auto-antibodies against the non-human sialic acid N-glycolylneuraminic acid.  J Exp Med 2010; 207:1637-1646.   ABSTRACT  |  PDF
JBC Rooijakkers SM, Rasmussen SL, McGillivray SM, Bartnikas TB, Mason AB, Friedlander AM, Nizet V.  Human transferrin confers serum resistance against Bacillus anthracisJ Biol Chem 2010; 285:27609-27613.  ABSTRACT  |  PDF
Journal of Infectious Diseases Hollands A, Pence MA, Timmer AM, Osvath SR, Turnbull L, Whitchurch CB, Walker MJ, Nizet V.  Genetic switch to hypervirulence reduces colonization phenotypes of the globally disseminated group A Streptococcus M1T1 clone.  J Infect Dis 2010; 202:11-19.   ABSTRACT  | PDF
JBC Gonzalez DJ, Lee SW, Hensler ME, Dahesh S, Markley AL, Mitchell DA, Bandeira N, Nizet V, Dixon JE, Dorrestein PC.  Clostridiolysin S: A post-translationally modified biotoxin from Clostridium botulinumJ Biol Chem 2010; 285:27798-27805.  ABSTRACT  |  PDF  |  Supplemental
JBC Kaur SJ, Nerlich A, Rohde M, Fulde MA, Zähner D, Hanski E, Zinkernagel A, Nizet V, Chhatwal GS, Talay SR. The CXC chemokine-degrading protease SpyCep of Streptococcus pyogenes promotes its uptake into endothelial cells.  J Biol Chem 2010; 285: 27798-27805.  ABSTRACT  | PDFSupplemental
Journal of
                Antibiotics Haste NM, Perera V, Maloney KN, Tran DN, Jensen PR, Fenical W, Nizet V and Hensler ME.  Activity of the streptogramin antibiotic etamycin against methicillin-resistant Staphylococcus aureus. J Antibiotics 2010; 63:219-224.  ABSTRACT PDF  |  Supplemental
Biochemical Journal Weiman S, Uchiyama S, Lin FY, Chaffin D, Varki A, Nizet V, Lewis AL. O-Acetylation of sialic acid on group B Streptococcus inhibits neutrophil suppression and virulence.  Biochem J 2010; 428:163-168.  ABSTRACT  |  PDF  
Science Translational Medicine Aziz RK, Nizet V.  Pathogen microevolution in high resolution. Sci Transl Med 2010; 2:16ps4  ABSTRACT  |  PDF
PNAS Stockmann C, Kerdiles Y, Nomaksteinsky M, Weidemman A, Takeda N, Doedens A, Torres-Collado AX, Iruela-Arispe L, Nizet V, Johnson RS.  Loss of inflammatory cell-derived vascular endothelial growth factor accelerates fibrosis.  Proc Natl Acad Sci USA 2010; 107:4329-4334.  ABSTRACT PDF  |  Supplemental
Diseases of Aquatic Organisms Locke JB, Ostland VE, Vicknair MR, Nizet V, Buchanan JT. Evaluation of Streptococcus iniae killed bacterin and live-attenuated vaccines in hybrid striped bass through injection and bath immersion. Dis Aquat Org 2010; 89:117-123.  ABSTRACT  |  PDF  
Journal of Molecular Medicine Nizet V.  Accentuate the (Gram) positive.  J Mol Med 2010; 88:93-95.  PDF
Mol Micro Kurupati P, Turner CE, Tziona I, Nohadani M, Stamp GW, Zinkernagel AS, Nizet V, Edwards RJ, Sriskandan S.  Chemokine-cleaving Streptococcus pyogenes protease SpyCEP is necessary and sufficient for bacterial dissemination within soft tissues and the respiratory tract.  Mol Microbiol 2010; 76:1387-1397.  ABSTRACT  |  PDF
Journal of Molecular Medicine Crotty-Alexander LE, Maisey HC, Timmer AM, Rooijakkers SHM, Gallo RL, von Köckritz-Blickwede M,  Nizet V. M1T1 group A streptococcal pili promote epithelial colonization but diminish systemic virulence through neutrophil extracellular entrapment.  J Mol Med 2010:88:371-881.  ABSTRACT  |  PDF
Microbiology Milani CJ, Aziz RK, Locke JB, Dahesh S, Nizet V, Buchanan JT.  The novel polysaccharide deacetylase homologue Pdi contributes to virulence of the aquatic pathogen Streptococcus iniaeMicrobiology 2010; 156:543-554.  ABSTRACT  |  PDF
PLoS One Cogen AL, Yamasaki K, Muto J, Sanchez KM, Crotty-Alexander L, Tanios J, Lai Y, Kim JE, Nizet V, Gallo RL.  Staphylococcus epidermidis antimicrobial δ-toxin (phenol soluble modulin-γ) cooperates with host antimicrobial peptides to kill Group A Streptococcus.  PLoS One  2010; 5:e8557.  ABSTRACT  |  PDF
Journal of Investigative
                Dermatology Cogen AL, Yamasaki K, Sanchez KM, Dorschner RA, Lai Y, McLeod D, Torpey J, Otto M, Nizet V, Kim JE, Gallo RL.  Selective antimicrobial action is provided by phenol soluble modulins derived from Staphylococcus epidermidis, a normal resident of the skin. J Invest Derm 2010; 130:192-200.   ABSTRACT  |   PDF
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Blood von Köckritz-Blickwede M, Chow OA, Nizet V. Fetal calf serum contains heat-stable nucleases that degrade neutrophil extracellular traps.  Blood 2009; 114:5245-5246.  PDF
Trends Microbiol Liu GY, Nizet V.  Color me bad:  Microbial pigments as virulence factors.  Trends Microbiol 2009; 17:406-413.   ABSTRACT PDF  |  Arsenio Explains Title
Nature Reviews Immunology Nizet V, Johnson RS.  Interdependence of hypoxic and innate immune responses. Nat Rev Immunol 2009; 9:609-617.  ABSTRACT  |  PDF  |  About the Cover 
J Exp Med Uchiyama S, Carlin AF, Khosravi A, Weiman S, Banerjee A, Quach D, Hightower G, Mitchell TJ, Doran KS, Nizet V. The surface-anchored NanA protein promotes pneumococcal brain endothelial cell invasion.  J Exp Med 2009; 206:1845-1852.   ABSTRACT PDF  |  Supplemental  |  Commentary  |  Press Release 
PNAS Lewis A, Desa N, Hansen E, Knirel Y, Gordon J, Gagneux P, Nizet V, Varki A. Innovations in host and microbial sialic acid biosynthesis revealed by phylogenomic prediction of nonulosonic acid structure. Proc Natl Acad Sci USA 2009; 106:13552-13557.  ABSTRACT  |  PDF  |  Supplemental
J Exp Med Carlin AF, Chang YC, Areschoug T, Lindahl G, Hurtado-Ziola N, King CC, Varki A, Nizet V. Group B Streptococcus suppression of phagocyte functions by protein-mediated engagement of human Siglec 5.  J Exp Med 2009; 206:1691-1699.  ABSTRACT  |  PDF  |  Supplemental  |  CommentaryPress Release  |  About the Cover  |  Podcast
Glycobiology Weiman S, Dahesh S, Carlin AF, Varki A, Nizet V, Lewis AL. Genetic and biochemical modulation of sialic acid O-acetylation on group B Streptococcus: phenotypic and functional impact. Glycobiology 2009; 19:1204-1213.  ABSTRACT  |  PDF
PLoS One Tseng CW, Kyme P, Low J, Rocha MA, Alsabeh R, Miller LG, Otto M, Arditi M, Diep BA, Nizet V, Doherty TM, Beenhouwer DO, Liu GY.  Staphylococcus aureus Panton-Valentine leukocidin contributes to inflammation and muscle tissue injury. PLoS One 2009; 4:e6837.  ABSTRACT  |  PDF  |  Supplemental
J Leukocyte
                Biology Jann N, Schmaler M, Kristian S, Gallo R, Nizet V, Peschel A, Landmann R.  Neutrophil antimicrobial defense against Staphylococcus aureus mediated by phagolysosomal but not extracellular trap-associated cathelicidin. J Leukocyte Biol 2009; 86:1159-1169.  ABSTRACT  |  PDF
PNAS Hruz P, Zinkernagel AS, Jenikova G, Botwin G, Hugot JP, Karin M, Nizet V, Eckmann L. NOD2 contributes to cutaneous defense against Staphylococcus aureus through α-toxin-dependent innate immune activation.  Proc Natl Acad Sci USA 2009; 106:12873-12878.  ABSTRACT  |  PDF Supplemental
Journal of Innate Immunity McGillivray SM, Ebrahimi CM, Fisher N, Sabet M, Chen Y, Haste NM, Aroian RV, Gallo RL, Guiney DG, Friedlander AM, Koehler TM, Nizet V. ClpX contributes to innate defense peptide resistance and virulence phenotypes of Bacillus anthracis. J Innate Immun 2009; 1:494-506.  ABSTRACT  |  PDF
Journal of Molecular Medicine von Köckritz-Blickwede M, Nizet V. Innate immunity turned inside-out: Antimicrobial defense by phagocyte extracellular traps.  J Mol Med 2009; 87:775–783.  ABSTRACT PDF
Journal of Medicinal
                Chemistry Song Y, Liu CI, Lin FY, No JH, Hensler ME, Liu YL, Jeng WY, Low J, Liu GY, Nizet V, Wang AHJ, Oldfield EO.  Inhibition of staphyloxanthin virulence factor biosynthesis in Staphylococcus aureusIn vitro, in vivo, and crystallographic results.  J Med Chem 2009; 52:3869-80.   ABSTRACT PDF
Journal of Infectious Diseases van Sorge NM, Quach D, Gurney MA, Sullam PM, Nizet V, Doran KS. The group B streptococcal Srr-1 glycoprotein mediates penetration of the blood-brain barrier. J Infect Dis 2009; 199:1479-1487.  ABSTRACT PDF
PNAS Navarini-Meury AA, Lang KS, Verschoor A, Recher M, Zinkernagel AS, Nizet V, Odermatt B, Hengartner H, Zinkernagel RM.  Innate immune-induced depletion of bone marrow neutrophils aggravates systemic bacterial infections. Proc Natl Acad Sci USA 2009; 106:7107-7112. ABSTRACT  |  PDF  |  Supplemental  |  Commentary
Immunology & Cell Biology Pinheiro da Silva F, Gallo RL, Nizet V.  Differing effects of exogenous or endogenous cathelicidin on macrophage Toll-like receptor signaling. Immunol Cell Biol 2009; 87:496-500.  ABSTRACT  |  PDF
PLoS One Cox KH, Ruiz-Bustos E, Courtney HS, Dale JB, Pence MA, Nizet V, Aziz RK, Gerling I, Price SM, Hasty DL.  Inactivation of DltABCD modulates virulence factor expression in Streptococcus pyogenesPLoS One 2009: e5366.  ABSTRACT  |  PDF
Journal of Innate Immunity Lauth X, von Köckritz-Blickwede M, McNamara CW, Myskowski S, Zinkernagel AS, Beall B, Ghosh P, Gallo RL, Nizet V.  M1 protein allows group A streptococcal survival in phagocyte extracellular traps through cathelicidin inhibition.  J Innate Immun 2009; 1:202 - 214.  ABSTRACT  |  PDF
JBC Mitchell DA, Lee SW, Pence MA, Markley AL, Limm JD, Nizet V, Dixon JE. Structural and functional dissection of the heterocycle peptide cytolysin streptolysin S.  J Biol Chem 2009; 284:13004-12ABSTRACT PDF
Apoptosis Pinheiro da Silva F, Nizet V.  Cell death during sepsis:  Integration of disintegration in the inflammatory response to overwhelming infection.  Apoptosis 2009; 14:509-521.  ABSTRACT  |  PDF
Blood Carlin AF, Uchiyama S, Chang YC, Lewis AL, Nizet V, Varki A. Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response.  Blood 2009; 113:3333-3336.  ABSTRACT  |  PDF
Journal of Medicinal
                Chemistry Song Y, Lin FY, Yin F, Hensler M, Rodrigues Poveda CA, Mukkamala D, Cao R, Morita CT, González-Pacanowska, Nizet V, Oldfield E.  Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus. J Med Chem 2009; 52:976-988.  ABSTRACT  |  PDF
Emerging Infectious Diseases Sendi P, Johansson L, Dahesh S, van Sorge NM, Darenberg J, Norgren M, Sjölin J, Nizet V, Norrby-Teglund A.  Bacterial phenotype variants in group B streptococcal toxic shock syndrome.  Emerg Infect Dis 2009; 15:223-232.  ABSTRACT  |  PDF
PLoS One Courtney HS, Ofek I, Penfound T, Nizet V, Pence MA, Kreikemeyer B, Podbielbski A, Hasty DL, Dale JB. Relationship between expression of the family of M proteins and lipoteichoic acid to hydrophobicity and biofilm formation in Streptococcus pyogenes. PLoS One 2009; 4:e4166ABSTRACT  |  PDF
Journal of Biological Chemistry Timmer AM, Timmer JC, Pence MA, Hsu LC, Ghochani M, Frey TG, Karin M, Salvesen GS, Nizet V. Streptolysin O promotes group A Streptococcus immune evasion by accelerated macrophage apoptosis.  J Biol Chem 2009; 284:862-871.  ABSTRACT  |  PDF
Essentials of Glycobiology Nizet V, Esko J.  Bacterial and viral infections.  Chapter 39 In: Essentials of Glycobiology, 2nd Edition (A Varki, R Cummings, J Esko, H Freeze, G Hart, J Marth, eds.)  Cold Spring Harbor Press, Boston, 2009.  PubMed  |  Online Book  |  PDF
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PLoS One Hollands A, Aziz RK, Kansal R, Kotb M, Nizet V, Walker MJ. A naturally occurring mutation in ropB suppresses SpeB expression and reduces M1T1 group A streptococcal systemic virulence.  PLoS One 2008 3:e4102. ABSTRACT  |  PDF
ERMM Maisey HC, Doran KS, Nizet V.  Recent advances in understanding the molecular basis of group B streptococcal virulence.  Exp Rev Mol Med 2008; 10:e27.  ABSTRACT  |  PDF
Nature Medicine
Nizet V, Rothenberg ME.  Mitochondrial missile defense.  Nat Med 2008; 9: 910-912.  ABSTRACT  |  PDF
Cell Host &
                Microbe Zinkernagel AC, Timmer AM, Pence MA, Locke JB, Buchanan JT, Turner CE, Mishalian I, Sriskandan S, Hanski E, Nizet V. IL-8 protease SpyCEP/ScpC promotes group A streptococcal resistance to neutrophil killing.  Cell Host Microbe 2008; 4:170-178.  ABSTRACT  |  PDF  |  Supplemental  |  Press Release
Drug Disc Today Gallo RL, Nizet V.  Innate barriers against skin infection and associated disorders.  Drug Disc Today Dis Mech 2008; 5:e145-e152.  ABSTRACT  |  PDF
                One Locke JB, Aziz RK, Vicknair MR, Nizet V, Buchanan JT.  Streptococcus iniae M-like protein contributes to virulence in fish and is a target for live-attenuated vaccine development. 2008; 3:e2824.  ABSTRACT PDF
                One Hensler ME, Miyamoto S, Nizet V.  Group B streptococcal β-hemolysin/ cytolysin directly impairs cardiomyocyte viability and function. PLoS One 2008 3:e2446.  ABSTRACT  |  PDF
AAC Dahesh S, Hensler ME, van Sorge NM, Gertz, RE, Schrag S, Nizet V, Beall BW.  Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to β-lactam antibiotics.  Antimicrob Agent Chemother 2008 52:2915-2918  ABSTRACT  |  PDF
J Exp Med Timmer AM, Nizet V.  IKKβ/NF-κB and the miscreant macrophage.  J Exp Med 2008 205:1255-1259.  ABSTRACT  |  PDF
PNAS Hsu LC, Ali R, McGillivray S, Tseng PH, Mariathasan S, Humke E, Eckmann L, Powell J, Nizet V, Dixit V, Karin M. A NOD2-NALP1 complex mediates caspase-1 dependent IL-1β secretion in response to Bacillus anthracis infection and muramyl dipeptide.  Proc Natl Acad Sci USA 2008 105:7803-7808.  ABSTRACT  |  PDF  | Supplemental
Nature Medicine Grewal PK, Uchiyama S, Ditto D, Varki N, Le DT, Nizet V, Marth JD.  The Ashwell receptor mitigates the lethal coagulopathy of sepsis.  Nature Med 2008 14:648-655.  ABSTRACT  |  PDFCommentary  |   Press Release 
Nature Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V, Johnson RS, Haddad GG, Karin M. NF-kB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α.  Nature 2008 454:807-811.   ABSTRACT  |  PDF  |  Supplemental  |  Press Release
PNAS Lee SW, Mitchell DA, Markley AL, Hensler ME, Gonzalez D, Wohlrab A, Dorrestein PC, Nizet V, Dixon JE.  Discovery of a widely distributed toxin biosynthetic gene cluster.  Proc Natl Acad Sci USA 2008 105:5879-5884. ABSTRACT  |  PDF  | Supplemental  |  Commentary
                Magazine McNamara CW, Zinkernagel AS, Macheboeuf P, Cunningham MW, Nizet V, Ghosh P.  Coiled-coil irregularities and instabilities in Group A Streptococcus M1 are required for virulence functions.  Science 2008; 319:1405-1408.  ABSTRACT  |  PDF  |  Supplemental  |  Press Release
                Magazine Liu C-I, Liu GY, Song Y, Yin F, Hensler ME, Jeng WY, Nizet V*, Wang AH*, Oldfield E*.  A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence.  Science 2008; 319:391-394. *share senior authorship  ABSTRACT  |  PDF  |  Supplemental  |  Press Release  |  Naked Scientists  |   NRDD  |  NEJM   |  Superbugs Bunny  |  Angew Chem 
Veterinary Microbiology Buchanan JT, Colvin KM, Vicknair MR, Patel SK, Timmer AM, Nizet V.  Strain-associated virulence patterns of Streptococcus iniae in hybrid-striped bass.  Vet Microbiol 2008; 131:145-153.  ABSTRACT  |  PDF
PPPID 3rd Edition Nizet V, Jackson MA.  Localized lymphadenitis, lymphadenopathy and lymphangitis.  In: Principles and Practices of Pediatric Infectious Diseases, 3rd Edition (S Long, LK Pickering, CG Prober, eds.). Churchill Livingstone, New York, p. 463-467, 2008.  Preview
BMC Micro Kraus D, Herbert S, Kristian S, Nizet V, Götz F, Peschel A. The GraRS regulatory system controls in vivo susceptibility of Staphylococcus aureus to antimicrobial host defenses.  BMC Microbiol 2008; 8:85.  ABSTRACT PDF
Journal of Investigative
                Dermatology Peyssonnaux C, Boutin A, Zinkernagel A, Datta V, Nizet V, Johnson RS. Critical role of HIF-1α in keratinocyte defense against bacterial infection.  J Invest Dermatol 2008; 128:1964-1968. ABSTRACT  |  PDF
FASEB Journal Maisey HC, Hensler ME, Quach D, Liu GY, Gallo RL, Nizet V, Doran KS.  A group B streptococcal pilus protein promotes phagocyte resistance and systemic virulence.  FASEB J 2008 22:1715-1724.  ABSTRACT  |  PDF
Journal of Infectious Diseases Zinkernagel AC, Peyssonnaux C, Johnson RS, Nizet V.  Pharmacological augmentation of HIF-1α with mimosine boosts the bactericidal capacity of phagocytes.  J Infect Dis 2008; 197:214-217.  ABSTRACT  |  PDF
Journal of
                Bacteriology Park B, Nizet V, Liu GY.  Role of Staphylococcus aureus catalase in niche competition against Streptococcus pneumoniae. J Bacteriol 2008; 190:2275-2278.  ABSTRACT  |  PDF
Journal of Biological
                Chemistry Gillen CM, Courtney HS, Schulze K, Rohde M, Wilson MR, Timmer AM, Guzman CA,  Nizet V, Chhatwal GS, and Walker MJ.  Opacity factor activity and epithelial cell binding by the serum opacity factor protein of Streptococcus pyogenes are functionally discrete.  J Biol Chem 2008; 283:6359-6366.  ABSTRACT  | PDF
British Journal of Dermatology Cogen AL, Nizet V, Gallo RL.  Skin microbiota: A source of disease or defence?  Br J Dermatol  2008 158:442-455.  ABSTRACT  |  PDF
Cell Cycle Peyssonnaux C, Nizet V, Johnson R.  Role of the hypoxia-inducible factors in iron metabolism.  Cell Cycle 2008 7:28-32.  ABSTRACT  | PDF
Bioorganical & Medicinal Chemistry Letters Meluzzi D, Zheng W, Hensler M, Nizet V, Dorrestein PC. Top-down mass spectrometry on low-resolution instruments: characterization of phosphopantheteinylated carrier domains in polyketide and non-ribosomal biosynthetic pathways. Bioorg Med Chem Lett 2008  18:3107-3111.  ABSTRACT  |  PDF
Microbial Pathogenesis Hensler ME, Quach D, Hsieh C.-J., Doran KS, Nizet V.  CAMP factor is not essential for systemic virulence of Group B StreptococcusMicrob Pathog 2008 44:84-88  ABSTRACT  |  PDF
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Journal of Molecular Medicine Zinkernagel AS, Johnson RS, Nizet V. Hypoxia inducible factor (HIF) function in innate immunity and infection.  J Mol Med 2007  85:1139-1146.  ABSTRACT  |  PDF
Proteomics Cole JN, Aquilina JA, Hains PJ, Henningham A, Sriprakash KS, Caparon MG, Pancholi V, Nizet V, Kotb M, Cordwell SJ, Djordjevic SP, Walker MJ.  Role of group A Streptococcus HrtA in the maturation of SpeB protease.  Proteomics  2007 7:4488-4498.  ABSTRACT  |  PDF
Nature Medicine Walker MJ, Hollands A, Sanderson-Smith M, Cole JN, Kirk JK, Henningham A, McArthur JD,  Dinkla K, Aziz RK, Kansal RG, Simpson AJ, Buchanan JT, Chhatwal GS, Kotb M, Nizet V. DNase Sda1 provides selection pressure for a switch to invasive group A streptococcal infection. Nat Med 2007 13:981-985. ABSTRACT  |  PDF  |  Supplemental | News & Views  |  Press Release
JBC Lewis AL, Cao H, Patel SK, Diaz S, Ryan W, Carlin AF, Thon V, Lewis WG, Varki A, Chen X, Nizet V.  NeuA O-acetylesterase activity modulates O-acetylation of capsular polysaccharides in group B Streptococcus.  J Biol Chem  2007 282:27562-27571  ABSTRACT  |  PDF
Blood Bayele HK, Peyssonnaux C, Giatromanolaki A, Arrais-Silva WW, Mohamed HS, Collins H, Giorgio S, Koukourakis M, Johnson RS, Blackwell JM, Nizet V, Sria SK.  HIF-1α regulates heritable variation and allele expression phenotypes of the macrophage immune response gene SLC11A1 from a Z DNA forming microsatellite.  Blood 2007 110:3039-3048.  ABSTRACT  |  PDF
JACI Nizet V.  Understanding how leading bacterial pathogens subvert innate immunity to reveal novel therapeutic targets.  J Allergy Clin Immunol 2007 120:13-22.  ABSTRACT  |  PDF
Peyssonnaux C, Zinkernagel AS, Scheupbach RA, Rankin E, Vaulont S, Haase VH, Nizet V*, Johnson RS*.  Regulation of iron homeostasis by the hypoxia inducible transcription factors (HIF)   J Clin Invest 2007 117:1926-1932. *share senior authorship  ABSTRACT  |  PDF Press Release
J Immunology Peyssonnaux C, Cejudo-Martin P, Doedens A, Zinkernagel AS, Johnson RS, Nizet V.  Cutting edge:  Essential role of hypoxia inducible factor-1α in development of LPS-induced sepsis.  J Immunol 2007 178:7516–7519.   ABSTRACT PDF
Locke JB, Colvin KM, Varki N, Vicknair MR, Nizet V, Buchanan JT.  The Streptococcus iniae beta-hemolysin streptolysin S is a virulence factor in fish infection. Dis Aquat Organ 2007 76:17-26.  ABSTRACT  |  PDF
Cell Host &
                Microbe Zinkernagel AS, Nizet V.  Staphylococcus aureus: A blemish on skin immunity.  Cell Host & Microbe 2007 1:161-162.  ABSTRACT PDF
J Bact Carlin AF, Lewis AL, Varki A, Nizet V.  Group B streptococcal capsular sialic acid interacts with Siglecs (immunoglobulin-like lectins) on human leukocytes.  J Bacteriol 2007 189:1231-1237. ABSTRACT  |  PDF
J Bact Kwinn LA, Khosravi A, Aziz RK, Timmer AM, Doran KS, Kotb M, Nizet V.  Genetic characterization and virulence role of the RALP3/LSA locus upstream of the streptolysin S operon in invasive M1T1 group A StreptococcusJ Bacteriol 2007 189:1322-1329. ABSTRACT  |  PDF
FASEB J Kristian SA, Timmer AM, Liu GY, Lauth X, Sal-Man N, Rosenfeld Y, Shai Y, Gallo RL, Nizet V.  Impairment of innate immune killing mechanisms by bacteriostatic antibiotics.  FASEB J 2007 21:1107-1116.  ABSTRACT  |  PDF
J Bact Maisey HC, Hensler MC, Nizet V, Doran KS.  Group B streptococcal pili proteins contribute to adherence and invasion of brain microvascular endothelial cells.  J Bacteriol 2007 189:1464-1467. ABSTRACT  |  PDF
Future Micro Kwinn LA,  Nizet V. How group A Streptococcus circumvents host phagocyte defenses.  Future Microbiol 2007 2:75-84.  ABSTRACTPDF
J Bact Locke JB, Colvin KM, Datta AK, Patel SK, Naidu NN, Neely MN, Nizet V, Buchanan JT.  Streptococcus iniae capsule impairs phagocytic clearance and contributes to virulence in fish. J Bacteriol 2007 189:1279-1287. ABSTRACT  |  PDF
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Mol Micro Timmer AM, Kristian SA, Datta V, Jeng A, Gillen CM, Walker MJ, Beall B, Nizet V.  Serum opacity factor promotes group A streptococcal epithelial cell invasion and virulence.  Mol Microbiol 2006 62:15-25.  ABSTRACT  |  PDF
Curr Biol Buchanan JT, Simpson AJ, Aziz RK, Liu GY, Kristian SA, Kotb M, Feramisco J, Nizet V.  DNase expression allows the pathogen group A Streptococcus to escape killing in neutrophil extracellular traps.  Curr Biol 2006 16:396-400.  ABSTRACT  |  PDF  |  Press Release
JBC Lewis ML, Hensler ME, Varki A, Nizet V.  The group B streptococcal sialic acid O-acetyltransferase is encoded by neuD, a conserved component of bacterial sialic acid biosynthetic gene clusters. J Biol Chem 2006 281:11186-11192.  ABSTRACT  |  PDF
Science Chen Y, Corriden R, Inoie Y, Yip L, Hashiguchi N, Zinkernagel A,  Nizet V, Insel PA, Junger WG.  ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors.  Science 2006  314:1792-1795.  ABSTRACT  |  PDF  |  Supplemental  |  Press Release
                Clin Micro Dehority W, Uchiyama S, Khosravi A, Nizet V.  Brain abscess caused by Streptococcus pyogenes in a previously healthy child.  J Clin Microbiol 2006 44:4613-4615.  ABSTRACT  |  PDF
Infect Immun Hamilton A, Popham DL, Carl DJ, Lauth X, Nizet V, Jones AL.  Penicillin-binding protein 1a promotes resistance of group B streptococcus to antimicrobial peptides.  Infect Immun 2006 74:6179-6187.  ABSTRACT PDF
EMBO J Hidalgo-Grass C, Mishalian I, Dan-Goor M, Belotserkovsky I, Eran Y, Nizet V, Peled A Hanski E. A streptococcal protease that locally degrades CXC chemokines subverting innate immune responses in the skin.  EMBO J  2006 25:4628-4637.  ABSTRACT  |  PDF
BMCL Hensler ME, Bernstein G, Nizet V, Nefzi A. Pyrrolidine bis-cyclic guanidines with antimicrobial activity against drug resistant Gram-positive pathogens identified from a mixture-based combinatorial library.  Bioorg Med Chem Lett 2006 16:5073-5079. ABSTRACT  | PDF
FASEB J Cole JN, McArthur JD, McKay FC, Sanderson-Smith ML, Cork AJ, Ranson M, Rohde M, Itzek A, Sun H, Ginsburg D, Kotb M, Nizet V, Chhatwal GS, Walker MJ.  Trigger for group A streptococcal M1T1 invasive infection.  FASEB J 2006 20:1745-1747.  ABSTRACT  |  PDF
Cell Karin M, Lawrence T, Nizet V.  Innate immunity gone awry:  Linking microbial infections to chronic inflammatory diseases and cancer.  Cell 2006 124:823-8235.  ABSTRACTPDF
Blood Peyssonnaux C, Zinkernagel AS, Datta V, Lauth X, Johnson RS, Nizet V.  TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens. Blood 2006 107:3727-3732. ABSTRACT  |  PDF
Liu GY, Nizet V.  The group B streptococcal ß-hemolysin/cytolysin.  In: The Comprehensive Sourcebook of Bacterial Protein Toxins, 3rd Edition.  Eds:  J Alouf, M Popoff.  Elsevier. 2006  PDF
Nizet V.  Antimicrobial peptide resistance mechanisms of human bacterial pathogens.  Curr Issues Mol Biol 2006 8:11-26.  ABSTRACT  |  PDF
Kristian SA, Datta V, Weidenmaier C, Kansal R, Fedtke I, Peschel A, Gallo RL, Nizet V.  DltABCD mediated D-alanylation of teichoic acids in group A Streptococcus confers innate immune resistance.  In Streptococci - New Insights Into an Old Enemy. International Congress Series 129. Elsevier. Amsterdam, p. 254-256. 2006.  PDF
Dorschner RA, Lopez-Garcia B, Peschel A, Kraus D, Morikawa K, Nizet V, Gallo RL.  The mammalian ionic environment dictates microbial susceptibility to antimicrobial defense peptides.  FASEB J 2006 20:35-42.  ABSTRACT  |  PDF
Timmer AM, Datta V, Kristian S, Jeng A, Beall B, Nizet V.  The contribution of serum opacity factor to group A streptococcal epithelial cell invasion. In Streptococci - New Insights Into an Old Enemy. International Congress Series 129. Elsevier. Amsterdam, p. 246-249. 2006.  PDF

Nizet V, Rubens CE.  Pathogenic mechanisms and virulence factors of group B streptococci.  In: Gram-positive pathogens, 2nd Edition.  Eds:  VA Fischetti, RP Novick, JJ Ferretti, DA Portnoy, JI Rood.  ASM Press 2006; pp. 152-168.
Maisey HC, Hensler ME, Khosravi A, Liu GY, Nizet V, Doran KS.  A single streptococcal gene can confer innate immune resistance and virulence to a nonpathogenic bacterium. In Streptococci - New Insights Into an Old Enemy. International Congress Series 129. Elsevier. Amsterdam, p. 223-226. 2006.  PDF
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Buchanan JT, Stannard JA, Lauth X, Ostland VE, Powell HC, Westerman ME, Nizet V. Streptococcus iniae phosphoglucomutase is a virulence factor and target for vaccine development.  Infect Immun 2005 73:6935-6944.  ABSTRACT  |  PDF
Kristian SA, Datta V, Weidenmaier C, Kansal R, Fedtke I, Peschel A, Gallo RL, Nizet V.  D-alanylation of teichoic acids promotes group A Streptococcus antimicrobial peptide resistance, neutrophil survival and epithelial cell invasion.  J Bacteriol  2005 187:6719-6725.  ABSTRACT  |  PDF
Doran KS, Engelson EJ, Khosravi A, Maisey HC, Fedtke I, Equils O, Michelsen KS, Arditi M, Peschel A, Nizet V. Group B Streptococcus blood-brain barrier invasion depends upon proper cell surface anchoring of lipoteichoic acid. J Clin Invest 2005  115:2499-2507.   ABSTRACT  |  PDF  |  JCI Commentary:  Abstract  |  PDF  |  Press Release
Liu GY, Essex A, Buchanan JT, Datta V, Hoffman HA, Bastian J, Fierer J, Nizet V.  Staphylococcus aureus golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activity.  J Exp Med  2005 202: 209-215.  ABSTRACT  |  PDF  |  About the Cover  |  Press Release  |  ASM News
Peyssonnaux C, Datta V, Cramer T, Doedens A, Theodorakis E, Gallo R, Hurtado-Ziola N, Nizet V*, Johnson RS*.  HIF-1alpha expression regulates the bactericidal capacity of phagocytes.  J Clin Invest 2005  115:1806-1815. *share senior authorship  ABSTRACT  |  PDF  |  JCI Commentary:  Abstract  PDF  |  Press ReleaseAudio Clip
Datta V, Myskowski SM, Kwinn LA, Chiem DN, Varki N, Kansal R, Kotb M, Nizet V.  Mutational analysis of the group A streptococcal operon encoding streptolysin S and its virulence role in invasive infection.  Mol Microbiol  2005 56:681-95.  ABSTRACTPDF
Lawrence T, Bebien M, Liu GY, Nizet V, Karin M.  IKKalpha limits macrophage NF-kB activation and contributes to the resolution of inflammation.  Nature  2005 434:1138-1143.  ABSTRACT  |  PDF  |  Press Release
Edwards MS, Nizet V, Baker CJ. Group B streptococcal infections.  In:  Infectious Diseases of the Fetus and Newborn Infant, 6th Edition.  Eds:  J Remington, J Klein, CJ Baker, CB Wilson. Elselvier Saunders, Philadelphia. pp. 404-464. 2006.
Braff MH, Zaiou M, Fierer J, Nizet V, Gallo R.  Keratinocyte production of cathelicidin provides direct antimicrobial activity against bacterial skin pathogens.  Infect Immun 2005 73:6771-6781. ABSTRACT  |  PDF
Hensler ME, Liu GY, Sobczak S, Benirshcke K, Nizet V, Heldt GP. Virulence role of the group B streptococcal ß-hemolysin/cytolysin in a neonatal rabbit model of early onset pulmonary infection. J Infect Dis  2005 191:1287-91.  ABSTRACT  |  PDF
Georgel P, Crozat K, Lauth X, Makrantonaki E, Seltmann H, Sovath S, Heobe K, Du X, Rutschmann S, Jiang Z, Bigby T, Nizet V, Zouboulis CC, Beutler B.  A TLR2-responsive lipid effector pathway protects mammals against Gram-positive bacterial skin infections.  Infect Immun 2005 73:4512-4521.  ABSTRACT  |  PDF  
Braff MH, Bardan A, Nizet V, Gallo RL.  Cutaneous defense mechanisms by antimicrobial peptides.  J Invest Dermatol  2005 125:9-13.  ABSTRACT  |  PDF
Lauth X, Babon J, Stannard JA, Singh S, Nizet V, Carlberg JM, Ostland VE, Pennington MW, Norton RS, Westerman ME.  Bass hepcidin: synthesis, solution structure, antimicrobial activities and synergism, and in vivo hepatic response to bacterial infections. J Biol Chem  2005; 280:9272-9282.  ABSTRACT  |  PDF

Nizet V. Antimicrobial peptide resistance in human bacterial pathogens.  In: Antimicrobial Peptides in Human Health and Disease.  Ed:  RL Gallo. Horizon Press, Norwich UK pp. 277-304.  2005.  ABSTRACT  

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