Center Investigator

Jane Burns, MD

Professor of Pediatrics

Dr. Burns directs the Kawasaki Disease (KD) Research Program, dedicated to excellence in basic, translational and clinical research regarding the etiology, pathogenesis, diagnosis and treatment of this important yet enigmatic multisystem inflammatory disorder of childhood. Epidemiological studies pinpoint clustering of KD cases in time and space in search of potential infectious or environmental triggers.  Ongoing family-based genomic association analysis of inflammatory and cardiovascular pathways have implicated polymorphisms in the genes encoding interleukin-4 and the chemokine receptor-ligand pair, CCR5 and CCL3L1, as risk factors for KD and adverse cardiovascular outcomes, in particular coronary artery aneurysms.  Innovative technologies are also being applied to validate nucleic acid and protein biomarkers from patient sera to enhance KD diagnosis and risk stratification.  Finally, the research program is studying the effectiveness of immunomodulatory treatment paradigms including intravenous gamma globulin and anti-TNFalpha monoclonal antibodies on outcome in both prototypical and refractory KD.

Primary II&I Focus Area:  Allergy & Autoimmunity
Secondary II&I Focus Area:  Inflammation & Tissue Injury

Laboratory Website    
Articles on PubMed

ENHANCE
IMMUNITYPREVENTINFECTIONALLEVIATEINFLAMMATION

Jane Burns, MD

Office: (858) 246-0155
Lab: (858)
FAX: (858) 246-0157
UCSD Mailcode: 0641
jcburns(at)ucsd.edu

Training:

U. of North Carolina (MD)
U. of Colorado
Harvard Medical School



Burns II&I

 Coronary artery aneurysms in a 9-year old boy, 3 years after diagnosis of Kawasaki Disease