Associate Investigator

Alexander Hoffmann, PhD

Associate Professor of Chemistry & Biochemistry

Reserach in the Hoffmann Laboratory is focused on the IκB/NF-κB signaling pathway, which plays critical roles in inflammation, immunity, stress responses and many human diseases such as cancer, immunodeficiencies, and arthritis. The two gene families comprise a total of 11 homologous proteins. Gene knockout studies in mice have shown that signaling via this pathway can have very diverse, even opposite physiological effects, e.g. cell proliferation vs senescence, survival vs apoptosis, pro- vs anti-inflammatory. The goal of our research program is to elucidate signal processing mechanisms within the IκB/NF-κB pathway and the specificity of its components as they relate to the stimulus-specific, gene-specific, and cell type-specific responses underlying diverse physiological functions  In our research we combine genetics (a comprehensive panel of IκB/NF-κB gene knockout mice and derived cells), biochemistry (track signaling intermediates in the cells), molecular biology (alter the balance of signal transducers, utilize marker genes, genome wide expression studies) to develop a computational model of IκB/NF-κB signaling. Computational simulations lead to predictions about natural and disease processes that are then tested experimentally. We hope not only to contribute generalizable insights into cellular signaling but also to provide leads for disease therapy.

Primary II&I Focus Area:  Innate Immunity
Secondary II&I Focus Area:  Immune Regulation

Laboratory Website    
Articles on PubMed


Alexander Hoffmann, PhD

Office: (858) 822-4670
Lab: (858) 822-4672
FAX: (858) 822-4671
UCSD Mailcode: 0375


Cambridge University (BA)
Rockefeller Unversity (PhD)

Hoffmann II&I

Model highlighting mechanisms that control stimulus-responsive NF-κB signaling activities