|Doris LaRock, PhD
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Doris was born in San Francisco, CA, and has lived all over the world including Hong Kong, England, and Canada. She earned her B.S. degree in Biology from Trinity College in Hartford CT, where she completed an honors thesis evaluating the genetic diversity of the threatened Florida crested caracara. She conducted her graduate studies with Dr. Sam Miller at the University of Washington and she studied a virulence factor of Salmonella, SseJ, that is delivered into host cells by the type 3 secretion system. She demonstrated SseJ regulates its enzymatic activity and subcellular localization by sensing the activation state of RhoA, and that this regulation is essential for Salmonella pathogenesis. Doris subsequently trained as a postdoctoral scientist with Dr. Scott Lesley at The Scripps Research Institute, characterizing a protein produced by the intestinal microbiota that agonizes host Wnt signaling and promotes stem cell differentiation.
In the Nizet lab, Doris is continuing her postdoctoral training with a novel screen to discover alternative classes of therapeutic drugs that can be used as antibiotics during infections with multi-drug resistant bacteria. This research is conducted in collaboration with the Infectious Diseases Discovery Group of Roche Pharma Research and Early Development (pRED) based in Basel, Switzlerland.