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Mu A, Klare WP, Baines SL, (multiple authors), Cole JN,
Nizet V, (multiple authors), Stinear TP, Schembri MA, Walker
MJ. Integrative omics identifies conserved and
pathogen-specific responses of sepsis-causing bacteria. Nat
Commun 2023;14:1530. ABSTRACT
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Catteau L, Iglesias YD, Tsunemoto H,
Pogliano J, Van Bambeke F, Nizet V, Sakoulas G. Nafcillin
augmentation of daptomycin and cathelicidin LL-37 killing of
methicillin-resistant Staphylococcus epidermidis:
foundations of successful therapy of endocarditis. Int J
Antimicrob Agents 2023; 61:106758. ABSTRACT
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Anderson E, Nair B, Nizet V, Kumar G. Man
vs microbes - the race of the century. J Med Microbiol
2023; 72(1). ABSTRACT
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Osowicki J, Nizet V. Malice in Chains. J
Infect Dis. 2023 Feb 7:jiad035. PDF |
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Pashangeh S, Berizi E, Majlesi M, Ghaderi S, Nizet V, Dahesh
S. Effect of eliminating hdcA gene of Staphylococcus
epidermidis TYH1 on histamine production. Iran J
Microbiol 2022;14:529-534. ABSTRACT
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Barajas-Mora EM, Lee L, Lu H, Valderrama
JA, Bjanes E, Nizet V, Feeney AJ, Hu M, Murre C.
Enhancer-instructed epigenetic landscape and chromatin
compartmentalization dictate a primary antibody repertoire
protective against specific bacterial pathogens. Nat
Immunol 2023;24:320-336. ABSTRACT
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Kumaraswamy M, Coady A, Szubin R, Martin
TC, Palsson B, Nizet V, Monk JM. Comprehensive whole genome
sequencing with hybrid assembly of multi-drug resistant Candida
albicans isolate causing cerebral abscess. Curr
Res Microb Sci 2023;4:100180. ABSTRACT
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Bjanes E, Zhou J, Qayum T, Zurich RH, Menon ND, Hoffman A, Fang RH, Zhang L, Nizet V. Outer membrane vesicle-coated nanoparticle vaccine protects against Acinetobacter baumannii pneumonia and sepsis. Adv Nanobiomed Res 2023; 3:2200130. ABSTRACT | PDF |
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Poudel S, Hefner Y, Szubin R, Sastry A,
Gao Y, Nizet V, Palsson BO. Coordination of CcpA and CodY
regulators in Staphylococcus aureus USA300 strains.
mSystems. 2022 Nov 2:e0048022. Epub ahead of
print. ABSTRACT
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Masso-Silva JA, Sakoulas G, Olay J,
Groysberg V, Geriak M, Nizet V, Crotty Alexander LE, Meier
A. Abrogation of neutrophil inflammatory pathways and
potential reduction of neutrophil-related factors in
COVID-19 by intravenous immunoglobulin. Front Immunol.
2022;13:993720. ABSTRACT
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Thomas SP, Denizer E, Zuffa S, Best BM,
Bode L, Chambers CD, Dorrestein PC, Liu GY, Momper JD, Nizet
V, Tsunoda SM, Tremoulet AH. Transfer of antibiotics and
their metabolites in human milk: Implications for infant
health and microbiota. Pharmacotherapy 2022 (epub
ahead of print) ABSTRACT
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Zhang F, Zhuang J, Li Z, Gong H, de Ávila
BE, Duan Y, Zhang Q, Zhou J, Yin L, Karshalev E, Gao W,
Nizet V, Fang RH, Zhang L, Wang J. Nanoparticle-modified
microrobots for in vivo antibiotic delivery to treat
acute bacterial pneumonia. Nat Mater 2022;
21:1324-1332. ABSTRACT
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Siew R, Ou TL, Dahesh S, Akong K, Nizet V.
Bicarbonate effects on antibacterial immunity and mucus
glycobiology in the cystic fibrosis lung: a review with
selected experimental observations. Infect Microb Dis
2022; 4:103-110. ABSTRACT
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Sorrentino JT, Golden GJ, Morris C,
Painter CD, Nizet V, Campos AR, Smith JW, Karlsson C,
Malmström J, Lewis NE, Esko JD, Gómez Toledo A. Vascular
proteome responses precede organ dysfunction in a murine
model of Staphylococcus aureus bacteremia. mSystems.
2022; 7:e0039522. ABSTRACT
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Bergmann R, Gulotta G, Andreoni F,
Sumitomo T, Kawabata S, Zinkernagel AS Chhatwal GS, Nizet V,
Rohde M, Uchiyama S. The group A Streptococcus
interleukin-8 protease SpyCEP promotes bacterial
intracellular survival by evasion of autophagy. Infect
Microb Dis 2022; 4:116-123. ABSTRACT
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Kapoor N, Uchiyama S, Pill S, Bautista L,
Yin L, Regan M, Chu E. Rabara T, Wong M, Fairman J, Nizet V.
Click chemistry-based technology for site-specific
polysaccharide conjugation allows a bacterial protein to
serve as both carrier and vaccine antigen. ACS Omega
2022; 7:24111-24120. ABSTRACT
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Passos LSA, Nizet V, Levine RA, Aikawa E.
Can we diagnose acute rheumatic fever early to maximize the
success of secondary prophylaxis in rheumatic heart valve
disease? Cardiovasc Res 2022; 118:e62-e65 ABSTRACT
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Menon N, Penziner S, Montaño E, Zurich R,
Pride D, Nair B, Kumar G, Nizet V. Increased innate immune
susceptibility in hyperpigmented bacteriophage-resistant
mutants of Pseudomonas aeruginosa. Antimicrob
Agents Chemother 2022; July 6: e0023922 (online
early) ABSTRACT
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Hirose Y, Kolesinski P, Hiraoka M,
Uchiyama S, Zurich RH, Kumaraswamy M, Bjanes E, Yamaguchi M,
Sumitomo T, Ghosh P, Kawabata S, Nizet V. Contribution
of Streptococcus pyogenes M87 protein to innate
immune resistance and virulence. Microb Pathogen
2022; 169:105636 ABSTRACT
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Kolesiński P, Wang KC, Hirose Y, Nizet V,
Ghosh P. An M protein coiled coil unfurls and exposes its
hydrophobic core to capture LL-37. ELife 2022;
11:e77989. ABSTRACT
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Gilbertie J, Ulloa ER, Daiker JC, Nguyen
K, Smelter D, Rose W, Geriak M, Schnabel LV, Nizet V,
Sakoulas G, Potent activity of ertapenem plus cefazolin
within staphylococcal biofilms: a contributing factor in the
treatment of methicillin-susceptible Staphylococcus
aureus endocarditis. Open Forum Infect Dis
2022; 5:ofac59 ABSTRACT
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Caffrey AR, Appaneal HJ, LaPlante KL,
Lopes VV, Ulloa ER, Nizet V, Sakoulas G. Impact of
clopidogrel on clinical outcomes in patients with Staphylococcus
aureus bacteremia: A national retrospective cohort
study. Antimicrob Agents Chemother 2022 Apr
13:e0211721 (online early) ABSTRACT
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Pashangeh S, Shekarforoush SS, Aminlari M,
Hosseinzadeh S, Nizet V, Dahesh S, Rahmdel S. Inhibition of
histamine accumulation by novel histamine degrading species
of Staphylococcus sp. isolated from goats and sheep
milk. Food Sci Nutr 2022; 10:354-362. ABSTRACT
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Moni M, Madathil T, Sathyapalan DT, Menon
V, Gutjahr G, Edathadathil F, Sureshkumar D, Prasanna P,
Jose S, Jerome R, Krishnan A, Pillai IC, Kumar G, Nair B,
Nizet V, and Jayant A. Clinical efficacy of inhaled nitric
oxide in preventing the progression of moderate to severe
COVID-19 and its correlation to viral clearance—Results of a
pilot study. Infect Microb Dis 2022; 4:26-33.
ABSTRACT
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Mejia M, Ottinger S, Vrbanac A, Babu P, Zulk J, Moorshead D, Bode L, Nizet V, Patras K. Human milk oligosaccharides reduce murine group B Streptococcus vaginal colonization with minimal impact on the vaginal microbiota. mSphere 2022; 7:e00885-2. ABSTRACT | PDF |
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Corriden R, Schmidt B, Olson J, Okerblom J, Masso Silva J, Nizet V, Meier A. Dexmedetomidine does not directly inhibit neutrophil extracellular trap production. Brit J Anaesthes 2022; 128:e51-e54. ABSTRACT | PDF |
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Holland ML, Bjanes E, Nizet V, Dillon NA. Bicarbonate modulates delafloxacin activity against multidrug-resistant Staphylococcus aureus and Pseudomonas aeruginosa. J Antimicrob Chemother 2022;77:433-442. ABSTRACT | PDF |
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Lee HW, Nizet V, An JN, Lee HS, Song YR,
Kim SG, Kim JK. Uremic serum damages endothelium by
provoking excessive neutrophil extracellular trap formation.
Sci Rep 2021; 11:21439. ABSTRACT
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Campeau A, Uchiyama S, Sanchez C, Sauceda C, Nizet V, Gonzalez D. The S protein of group B Streptococcus is a critical virulence determinant that impacts the cell surface virulome. Front Microbiol 2021; 12:729308. ABSTRACT | PDF |
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Yamaguchi M, Kinjo Y, Nizet V. Editorial:
Host-pathogen interactions during pneumococcal infection. Front
Cell Infect Microbiol 2021; 11:752959. ABSTRACT
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Kumaraswamy M, Wiull K, Joshi B, Sakoulas
G, Kousha A, Vaaje-Kolstad G, Johannessen M, Hegstad K,
Nizet V, Askarian F. Bacterial membrane-derived vesicles
attenuate vancomycin activity against methicillin-resistant
Staphylococcus aureus. Microorganisms 2021;
9:2055. ABSTRACT
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Golden G, Toledo A, Marki A, Sorrentino J, Morris C, Riley R, Spliid C, Chen Q, Cornax I, Lewis N, Varki N, Le D, Malmström J, Karlsson C, Ley K, Nizet V, Esko J. Endothelial heparan sulfate mediates hepatic neutrophil trafficking and injury during Staphylococcus aureus sepsis. mBio 2021; 12:e01181-21. ABSTRACT | PDF |
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Gao NJ, Rodas Lima E, Nizet V.
Immunobiology of the classical Lancefield group A
streptococcal carbohydrate antigen. Infect Immun
2021; 89:e00292-21. ABSTRACT
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Kim JK, Uchiyama S, Gong H, Stream A,
Zhang L, Nizet V. Engineered biomimetic platelet
membrane-coated nanoparticles block Staphylococcus
aureus cytotoxicity and protect against lethal
systemic infection. Engineering 2021;
7:1149-1156. ABSTRACT
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Rada C, Mejia-Pena H, Grimsey N, Canto
Cordova I, Olson J, Wozniak J, Gonzalez DJ, Nizet V, Trejo
J. Heat Shock Protein 27 activity is linked to endothelial
barrier resolution induced by GPCR pro-inflammatory
mediators. Sci Signal 2021;14,:eabc1044 ABSTRACT
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Richter J, Monteleone M, Cork A, Barnett
T, Nizet V, Brouwer S, Schroder K, Walker M. Streptolysins
are the primary inflammasome activators in macrophages
during Streptococcus pyogenes infection. Immunol
Cell Biol 2021; 99:1040–1052 ABSTRACT
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Sastry AV, Dillon N, Anand A, Poudel S,
Hefner Y, Xu S, Szubin R, Feist AM, Nizet V, Palsson B.
Machine learning of bacterial transcriptomes reveals
responses underlying differential antibiotic susceptibility.
mSphere 2021; 6:e0044321. ABSTRACT
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Machado H, Seif Y, Sakoulas G, Olson CA,
Szubin R, Palsson BO, Nizet V, Adam M, Feist A.
Environmental conditions dictate differential evolution of
vancomycin resistance in Staphylococcus aureus. Commun
Biol 2021; 4:793. ABSTRACT
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Rose WE,
Fantl M, Geriak M, Nizet V, Sakoulas G. Current paradigms
of combination therapy in methicillin-resistant Staphylococcus aureus (MRSA) bacteremia: does it work, which combination
and for which patients? Clin Infect Dis 2021;
73:2353–60. ABSTRACT
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Ulloa ER, Uchiyama S, Gillespie R, Nizet
V, Sakoulas G. Ticagrelor increases platelet-mediated Staphylococcus
aureus killing resulting in clearance of bacteremia. J
Infect Dis 202; 1224:1566–9. ABSTRACT
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Lum G, Mercado V, van Ens D, Nizet V,
Kimmey JM, Patras KA. Hypoxia-inducible factor 1 alpha is
dispensable for host defense of group B Streptococcus
colonization and infection. J Innate Immun 2021;
13:391–403. ABSTRACT
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Hirose Y, Yamaguchi M, Sumitomo T, Nakata
M, Hanada T, Okuzaki D, Motooka D, Mori Y, Kawasaki H, Coady
A, Uchiyama S, Hiraoka M, Zurich RH, Amagai M, Nizet
V, Kawabata S. Streptococcus pyogenes
upregulates arginine metabolism to exert its pathogenesis on
the skin surface. Cell Reports 2021;
34:108924. ABSTRACT
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Sun J, Uchiyama S, Olson J, Morodomi Y,
Cornax I, Ando N, Kohno Y, Kyaw MMT, Aguilar B, Haste NM,
Kanaji S, Kanaji T, Rose WE, Sakoulas G, Marth JD, Nizet
V. Repurposed drugs block toxin-driven platelet
clearance by the hepatic Ashwell-Morell receptor to clear Staphylococcus
aureus bacteremia. Sci Transl Med 2021;
13:eabd6737. ABSTRACT
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Bier E, Nizet V. Driving to safety:
CRISPR-based genetic approaches to reducing antibiotic
resistance. Trends Genet 2021;
37:745-757. ABSTRACT
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Askarian F, Uchiyama S, Masson H, Bunaes AC, Golten O, Mekasha S, Røhr ÅK, Kommedal E, Ludviksen JA, Sørenson HV, Arntzen MØ, Schmidt B, van Sorge NM, Eijsink VG, Krengel U, Mollnes TE, Lewis NE, Nizet V, Vaaje-Kolstad G. The lytic polysaccharide monooxygenase CbpD promotes Pseudomonas aeruginosa virulence in systemic infection. Nat Commun 2021; 12:1230. ABSTRACT | PDF | Supplemental |
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Bjanes E, Nizet V. More than a pore: non-lytic antimicrobial functions of complement and bacterial strategies for evasion. Microbiol Mol Biol Rev 2021; 85:e00177-20. ABSTRACT | PDF |
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Saha S, Coady A, Sasmal A, Kawanishi K,
Choudhury B, Yu H, Sorensen R, Inostroza J, Schoenhofen I,
Chen X, Münster-Kühnel A, Sato C, Kitajima K, Ram S, Nizet
V, Varki A. Exploring the impact of ketodeoxynonulosonic
acid in host-pathogen interactions using uptake and surface
display by nontypeable Haemophilus influenzae. mBio
2021; 12:e03226-20. ABSTRACT
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Cornax I, Zulk J, Olson J, Fulde M, Nizet
V, Patras KA. Novel models of Streptococcus canis
colonization and disease reveal modest contributions of
M-like (SCM) protein. Microorganisms 2021;
9:183. ABSTRACT
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Menon ND, Kumar MS, Satheesh Babu TG,
Bosee S, Vijayakumara G, Baswe M, Chatterjee M, D’Silva JR,
Shetty K, Haripriyan J, Kumar A, Nair S, Somanath P, Nair
BG, Nizet V, Kumar GB. A novel N4-like bacteriophage
isolated from a wastewater source in South India with
activity against several multidrug-resistant clinical Pseudomonas
aeruginosa isolates. mSphere 2021;
6:e01215-20. ABSTRACT
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Gao NJ, Uchiyama S, Pill L, Dahesh S,
Olson J, Bautista L, Maroju S, Berges A, Liu JZ, Zurich RH,
van Sorge NM, Fairman F, Kapoor N, Nizet V. Site-specific
conjugation of cell wall polyrhamnose to protein SpyAD
envisioning a safe universal group A streptococcal vaccine.
Infect Dis Microb 2021; 3:87-100. ABSTRACT
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Rajput A, Poudel S, Tsunemoto H, Meehan M, Szubin R, Olson CA, Seif Y, Lamsa A, Dillon N, Vrbanac A, Sugie J, Dahesh S, Monk JM, Dorrestein PC, Knight R, Pogliano P, Nizet V, Feist AM, Palsson BO. Identifying the effect of vancomycin on healthcare-associated methicillin-resistant Staphylococcus aureus strains using bacteriological and physiological media. GigaScience 2021; 10:giaa156. ABSTRACT | PDF |
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Marki A, Buscher K, Lorenzini C, Meyer M, Saigusa R, Fan Z, Yeh YT, Hartmann N, Golden G, Dan J, Kiosses W, Ganesan R, Winkels H, Orecchioni M, McArdle S, Mikulski Z, Altman Y, Bui J, Kronenberg M, Esko J, Chien S, Nizet V, Smalley D, Roth J, Ley K. Elongated neutrophil-derived structures (ENDS) are novel blood borne microparticles formed by rolling neutrophils during sepsis. J Exp Med 2021; 218:e20200551. ABSTRACT | PDF |
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Liu X, Kimmey JM, Matarazzo L, de Bakker V, Van Maele L, Sirard JC, Nizet V, Veening JW. Exploration of bacterial bottlenecks and Streptococcus pneumoniae pathogenesis by CRISPRi-seq. Cell Host Microbe 2021; 29:P107-120.E6 ABSTRACT | PDF | Press Release |
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Wilde S, Olivares KL, Nizet V, Hoffman HM, Radhakrishna S, LaRock CN. Opportunistic invasive Infection by group A Streptococcus during anti-interleukin-6 immunotherapy. J Infect Dis 2021; 223:1260-1264. ABSTRACT | PDF |
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Hirose Y, Yamaguchi M, Takemoto N,
Miyoshi-Akiyama T, Sumitomo T, Nakata M, Ikebe T, Hanada T,
Yamaguchi T, Kawahara R, Okuno R, Otsuka H, Matsumoto Y,
Terashima Y, Kazawa Y, Nakanishi N, Uchida K, Akiyama Y,
Iwabuchi K, Nakagawa C, Yamamoto K, Nizet V, Kawabata S.
Genetic characterization of Streptococcus pyogenes emm89
strains isolated in Japan from 2011 to 2019. Infect
Microbe Dis 2020; 2:160-166. ABSTRACT
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Washington A, Varki N, Valderrama JA,
Nizet V, Bui JD. Evaluation of interleukin-17D in host
immunity to group A Streptococcus infection. J
Immunol 2020; 205:3122-3129. ABSTRACT
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Swanson S, Katkar G, Tam J, Pranadinata R,
Chareddy Y, Coates J, Olson J, Nizet V, Kufareva I, Das S,
Castillo V, Ghosh P. TLR4 signaling and macrophage
inflammatory responses are dampened by GIV/Girdin. Proc
Natl Acad Sci USA 2020; 117:26895-26906. ABSTRACT
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Ulloa ER, Singh KV, Geriak M, Haddad F, Murray BE, Nizet V, Sakoulas G. Cefazolin and ertapenem salvage therapy rapidly clears persistent methicillin-susceptible Staphylococcus aureus bacteremia. Clin Infect Dis 2020; 71:1413-1418. ABSTRACT | PDF |
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Vrbanac A, Patras KA, Jarmusch AK, Mills
RH, Shing S, Quinn RA, Vargas F, Gonzalez DJ, Dorrestein PC,
Knight R, Nizet V. Evaluating organism-wide changes in the
metabolome and microbiome following a single dose of
antibiotic. mSystems 2020; 5:e00340-20.
ABSTRACT
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Brouwer S, Barnett TC, Ly D, Kasper KJ, De
Oliveira DM, Rivera-Hernandez T, Cork AJ, McIntyre L,
Jespersen MG, Richter J, Schulz BL, Dougan G, Nizet V, Yuen
KY, You Y, McCormick JK, Sanderson-Smith ML, Davies MR,
Walker MJ. Prophage exotoxins enhance colonization fitness
in epidemic scarlet fever-causing Streptococcus pyogenes.
Nat Comm 2020; 11:5018. ABSTRACT
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Sun J, LaRock DL, Skowronski E, Kimmey JM,
Olson J, Jiang Z, O’Donoghue AJ, Nizet V, LaRock CN. The
Pseudomonas aeruginosa protease LasB directly
activates IL-1β. EBiomedicine 2020; 60:102984. ABSTRACT
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Wozniak JM, Mills RH, Olson J, Caldera JR,
Poore GD, Carrillo-Terrazas M, Tsai CM, Vargas F, Knight R,
Dorrestein PC, Liu GY, Nizet V, Sakoulas G, Rose W, Gonzalez
DJ. Mortality risk profiling of Staphylococcus aureus
bacteremia by multi-omic serum analysis reveals early
predictive and pathogenic molecular signatures. Cell
2020; 182:1067-1362. ABSTRACT
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Campeau A, Mills R, Blanchette M, Bajc K,
Malfavon M, Munji R, Deng L, Hancock B, Patras K, Olson J,
Nizet V, Daneman R, Doran K, and Gonzalez D.
Multi-dimensional proteome profiling of blood-brain barrier
perturbation by group B Streptococcus. mSystems
2020; 5:e00368-20. ABSTRACT
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Chen YH, Li SH, Yang YC, Hsu SH, Nizet V,
Chang YC. T4 pili promote colonization and immune evasion
phenotypes of non-encapsulated M4 Streptococcus pyogenes. mBio 2020; 11: e01580-20. ABSTRACT | PDF |
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Berti I, Rose WE, Nizet V, Sakoulas
G. Antibiotics and innate immunity: a cooperative
effort towards the successful treatment of infections.
Open Forum Infect Dis 2020; 7:ofaa302. ABSTRACT
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Volk CF, Burgdorf S, Edwarson GW, Nizet V, Sakoulas G, Rose W. IL-1β and IL-10 host responses in patients with Staphylococcus aureus bacteremia determined by antimicrobial therapy. Clin Infect Dis 2020; 70:2634-2640 ABSTRACT | PDF |
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Woehl JL, Kitamura S, Dillon N, Edgar LJ,
Han Z, Nizet V, Wolan DW. An irreversible inhibitor to probe
the role of Streptococcus pyogenes cysteine protease
SpeB in evasion of host complement defenses. ACS
Chem Biol 2020; 15: 2060-2069. ABSTRACT
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Poudel S, Tsunemoto H, Seif Y, Sastry AV,
Szubin R, Xu S, Machado H, Olson CA, Anand A, Pogliano J,
Nizet V, Palsson BO. Revealing 29 sets of independently
modulated genes in Staphylococcus aureus, their
regulators and role in key physiological responses. Proc
Natl Acad Sci 2020; 117:17228-17239. ABSTRACT
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Kitamura S, Zheng Q, Woehl, J, Solania A,
Chen E, Dillon N, Hull M, Kotaniguchi M, Cappiello J,
Kitamura S, Nizet V, Sharpless KB, Wolan D. Sulfur(VI)
fluoride exchange (SuFEx)-enabled high-throughput medicinal
chemistry. J Am Chem Soc 2020;
142:10899-10904. ABSTRACT
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Li Y, Fin A, Rovira A, Su Y, Dippel A,
Valderrama JA, Riestra A, Nizet V, Hammond MC, Tor Y. Tuning
the innate immune response to cyclic dinucleotides using
atomic mutagenesis. ChemBioChem 2020;
21:2595-2598. ABSTRACT
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Lund SJ, Patras KA, Kimmey JM, Yamamura A,
Butcher LD, Del Rosario PG, Hernandez GE, McCoy AM, Lakhdari
O, Nizet V, Prince LS. Developmental immaturity of Siglec
receptor expression on neonatal alveolar macrophages
predisposes to severe group B streptococcal infection. iScience
2020; 23:101207. ABSTRACT
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Shewell LK, Day CJ, Jen FE, Haselhorst T,
Atack JM, Reijneveld JF, Everest-Dass A, James DB,
Boguslawski KM, Brouwer S, Gillen CM, Luo Z, Kobe B, Nizet
V, von Itzstein M, Walker MJ, Adrienne W. Paton AW, Paton
JC, Torres VJ, Jennings MP. All major
cholesterol-dependent cytolysins use glycans as cellular
receptors. Sci Adv 2020; 6:eaaz4926. ABSTRACT
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Patras K, Coady A, Babu P, Shing S, Ha A,
Rooholfada E, Brandt S, Geriak M, Gallo RL, Nizet V. Host
cathelicidin exacerbates group B Streptococcus
urinary tract infection. mSphere 2020;
5:e00932-19. ABSTRACT
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Lawrence SM, Corriden R, Nizet V. How
neutrophils meet their end. Trends Immunol
2020; 41:531-544. ABSTRACT
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Salazar M, Machado H, Dillon N, Tsunemoto
H, Szubin R, Dahesh S, Pogliano J, Sakoulas G, Palsson BO,
Nizet V, Feist A. Genetic determinants enabling
media-dependent adaptation to nafcillin in
methicillin-resistant Staphylococcus aureus. mSystems
2020; 5:e00828-19. ABSTRACT
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Chang YC, Nizet V. Siglecs at the
host-pathogen interface. Adv Exp Med Biol 2020;
1204:197-214. ABSTRACT
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Lee HS, Park MJ, Yoon SY, Joo N, Song YR,
Kim HJ, Kim SG, Nizet V, Kim JK. Role of peribrachial fat as
a key determinant of brachial artery dilatation for
successful arteriovenous fistula maturation in hemodialysis
patients. Sci Rep 2020; 10:3841. ABSTRACT
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Quinn RA, Melnik AV, Vrbanac A, Fu T,
Patras KA, Christy MP, Bodai Z, Belda-Ferre P, Tripathi A,
Chung LK, Downes M, Welch RD, Quinn M, Humphrey G,
Panitchpakdi M, Weldon KC, Askenov A, da Silva R,
Avila-Pacheco J, Clish C, Bae S, Mallick H, Franzosa EA,
Lloyd-Price J, Bussell R, Thron T, Nelson AT, Wang M,
Leszczynski E, Vargas F, Gauglitz JM, Meehan MJ, Gentry E,
Arthur TD, Komor AC, Poulsen O, Boland BS, Chang JT,
Sandborn WJ, Lim M, Garg N, Lumeng JC, Xavier RJ,
Kazmierczak BI, Jain R, Egan M, Rhee KE, Ferguson D,
Raffatellu M, Vlamakis H, Haddad GG, Siegel D, Huttenhower
C, Mazmanian SK, Evans RM, Nizet V, Knight R, Dorrestein PC.
Global chemical impacts of the microbiome include novel bile
acid conjugations. Nature 2020;
579:123–129. ABSTRACT
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Ulloa ER,
Kousha A, Tsunemoto H, Pogliano J, Licitra C, LiPuma JJ,
Sakoulas G, Nizet V, Kumaraswamy M. Azithromycin exerts
bactericidal activity and enhances innate immune-mediated
killing of MDR Achromobacter xylosoxidans. Infect Microb Dis 2020;
2:10-17. ABSTRACT
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Shing SR, Ramos AR, Patras KA, Riestra AM,
McCabe S, Nizet V, Coady A. The fungal pathogen Candida
albicans promotes bladder colonization of group B Streptococcus.
Front Cell Infect Microbiol 2020;
9:437. ABSTRACT
| PDF | Supplemental |
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Denholtz M, Zhu Y, He Z, Lu H, Isoda T,
Döhrmann S, Nizet V, Murre C. Upon microbial
challenge, human neutrophils undergo rapid changes in
nuclear architecture and chromatin folding to orchestrate an
immediate inflammatory gene program. Genes Dev 2020;
34:149-165. ABSTRACT
| PDF
| Supplemental
| Cover Article |
| 2 0 1 9 | |
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Rajput A, Poudel S, Tsunemoto H, Meehan M,
Szubin R, Olson CA, Lamsa A, Seif Y, Dillon N, Vrbanac A,
Sugie J, Dahesh S, Monk JM, Dorrestein PC, Knight R, Nizet
V, Palsson BO, Feist AM, Pogliano J. Profiling the effect of
nafcillin on HA-MRSA D712 using bacteriological and
physiological media. Sci Data 2019;
6:322. ABSTRACT
| PDF |
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Valderrama JA, Kulkarni SS, Nizet V, Bier
E. A bacterial gene-drive system efficiently edits and
inactivates a high copy number antibiotic resistance locus.
Nat Comm 2019; 10:5726. ABSTRACT
| PDF | Supplemental | Press
Release |
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Tsai CM, Riestra AM, Ali SR, Fong JJ, Liu
JZ, Hughes G, Varki A, Nizet V. Siglec-14 enhances
NLRP3-inflammasome activation in macrophages. J Innate
Immun 2019; 11:86-98. ABSTRACT
| PDF |
Supplemental |
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Tacke R, Sun J, Uchiyama S, Polovina A,
Nguyen DG, Nizet V. Protection against lethal
multidrug-resistant bacterial infections using macrophage
cell therapy. Infect Microb Dis 2019;
1:61-69. ABSTRACT
| PDF |
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Koo J, Escajadillo T, Zhang L, Nizet V, Lawrence SM. Erythrocyte-coated nanoparticles block cytotoxic effects of group B Streptococcus β-hemolysin/cytolysin. Front Pediatr 2019; 7:410. ABSTRACT | PDF |
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Machado H, Weng L, Dillon N, Seif Y,
Holland M, Pekar J, Monk J, Nizet V, Palsson B, Feist
A. Strain-specific metabolic requirements revealed by
a defined minimal medium for systems analyses of
Staphylococcus aureus. Appl Environ
Microbiol 2019; 85:e01773-19. ABSTRACT |
PDF |
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Gomez Toledo A, Golden G, Rosa-Campos A,
Cuello H, Sorrentino J, Lewis N, Varki N, Nizet V, Smith JW,
Esko JD. Proteomic atlas of organ vasculopathies triggered
by Staphylococcus aureus sepsis. Nat Comm
2019; 10:4656 ABSTRACT
| PDF |
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Gao NJ, Al-Bassam MM, Poudel S, Wozniak
JM, Gonzalez DJ, Olson J, Zengler K, Nizet V, Valderrama JA.
Functional and proteomic analysis of Streptococcus
pyogenes virulence upon loss of its native Cas9
nuclease. Front Microbiol 2019; 10:1967.
ABSTRACT
| PDF | Supplemental |
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Cohen-Katsenelson K, Stender JD, Uchiyama
S, Grezchnik AT, Nizet V, Glass CK, Newton AC. PH
domain leucine rich repeat protein phosphatase 1 (PHLPP1)
counter-regulates STAT1-mediated inflammatory
signaling. eLife 2019; 8:e48609. ABSTRACT
| PDF | Press
Release |
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Dillon N, Holland M, Tsunemoto H, Hancock
B, Cornax I, Pogliano J, Sakoulas G, Nizet V. Dual bacterial
translation inhibitors azithromycin and minocycline
demonstrate synergy against multidrug-resistant Acinetobacter
baumannii. eBiomedicine 2019;
46:193-201. ABSTRACT
| PDF |
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LaRock DL, Sands J, Ettouati E, Richard M,
Bushway PJ, Adler ED, Nizet V, LaRock CN. Inflammasome
inhibition blocks cardiac glycoside cellular toxicity. J
Biol Chem 2019; 294:12846-12854. ABSTRACT
| PDF
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Dahesh S, Wong B, Nizet V, Sakoulas G
(Discussion by Tran TT, Aitken SL). Treatment of
multidrug-resistant vancomycin-resistant Enterococcus
faecium hardware-associated vertebral osteomyelitis
with oritavancin plus ampicillin. Antimicrob Agents
Chemother 2019; 63:e02622-18. ABSTRACT
| PDF |
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Patras KA, Ha AD, Rooholfada E, Olson J,
RamachandraRao SP, Lin AE, Nizet V. Augmentation of urinary
lactoferrin enhances host innate immune clearance of
uropathogenic E. coli. J Innate Immun
2019; 11:481-495. ABSTRACT
| PDF |
Supplemental |
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Rivera-Hernandez T, Carnathan D, Jones S,
Cork A, Davies M, Moyle P, Toth I, Batzloff M, McCarthy J,
Nizet V, Goldblatt D, Silvestri G, Walker MJ. An
experimental group A Streptococcus vaccine that
reduces pharyngitis and tonsillitis in a non-human primate
model. mBio 2019; 10:e00693-19. ABSTRACT
| PDF | Supplemental |
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Poudel S, Tsunemoto H, Meehan M, Szubin R,
Olson C, Lamsa A, Seif Y, Dillon N,Vrbanac A, Sugie J,
Dahesh S, Monk J, Dorrestein P, Pogliano J, Knight R, Nizet
V, Palsson B, Feist A. Characterization of CA-MRSA TCH1516
exposed to nafcillin in bacteriological and physiological
media. Sci Data 2019; 6:43. ABSTRACT
| PDF |
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Ulloa ER, Dillon N, Tsunemoto H, Pogliano
J, Sakoulas G, Nizet V. Avibactam sensitizes
carbapenem-resistant NDM-1-producing Klebsiella
pneumoniae to innate immune clearance. J
Infect Dis 2019; 220:484-493. ABSTRACT
| PDF | Supplemental |
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Zhang Q, Chao TC, Patil VS, Qin Y, Tiwari
SK, Chiou J, Dobin A, Tsai CM, Li Z, Dang J, Gupta S, Urdahl
K, Nizet V, Gingeras TR, Gaulton KJ, Rana TM. The long
noncoding RNA ROCKI regulates inflammatory gene
expression. EMBO J 2019; 38:e100041. ABSTRACT
| PDF | Blog
Post |
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Uchiyama S, Sun J, Fukahori K, Ando N, Wu
M, Schwarz F, Siddiqui SS, Varki A, Marth JD, Nizet V.
Dual actions of group B Streptococcus capsular
sialic acid provide resistance to platelet-mediated
antimicrobial killing. Proc Natl Acad Sci USA
2019; 116:7465-7470. ABSTRACT
| PDF | Blog
Post |
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Caffrey AR, Timbrook TT, Ali SR, Nizet V,
Sakoulas G. Proton pump inhibitors do not influence clinical
outcomes in patients with Staphylococcus aureus
bacteremia. Therap Adv Gastroenterol 2019;
12:1756284819834273. ABSTRACT
| PDF |
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Meier A, Chien J, Hobohm L, Patras KA, Nizet V, Corriden R. Inhibition of human neutrophil extracellular trap (NET) production by propofol and lipid emulsion. Front Pharmacol 2019; 10:323. ABSTRACT | PDF |
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Geriak M, Haddad F, Rizvi K, Rose W,
Kullar R, LaPlante K, Yu M, Vasina L, Oueletter K, Zervos M,
Nizet V, Sakoulas G. Clinical data on daptomycin plus
ceftaroline versus standard of care monotherapy in the
treatment of methicillin-resistant Staphylococcus aureus
bacteremia. Antimicrob Agents Chemother 2019;
63:e02483-18. ABSTRACT
| PDF |
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Bauman KD, Li J, Murata K, Mantovani SM,
Dahesh S, Nizet V, Luhavaya H, Moore BS. Refactoring
the cryptic streptophenazine biosynthetic gene cluster
unites phenazine, polyketide, and nonribosomal peptide
biochemistry. Cell Chem Biol 2019;
6:724-736. ABSTRACT
| PDF
| Supplemental |
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Nerlich A, Lapschies AM, Kohler TP, Cornax
I, Eichhorn I, Goldmann O, Krienke P, Bergmann S, Nizet V,
Hammerschmidt S, Rohde M, Fulde M. Homophilic protein
interactions facilitate bacterial aggregation and
IgG-dependent complex formation by the Streptococcus
canis M protein SCM. Virulence 2019;
10:194-206. ABSTRACT
| PDF |
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Dan JM, Havenar-Daughton C, Kendric K,
Kaushik K, Rosales S, Anderson E, LaRock C, Pandurangan V,
Seumois G, Layfield D, Cutress R, Ottensmeier C,
Lindestam Alrehman C, Sette A, Nizet V, Bothwell M, Brigger
M, Crotty S. Recurrent tonsillitis is a genetic
immunosusceptibility disease associated with poor antibody
responses and aberrant T follicular helper cells. Sci
Transl Med 2019; 11:eaau3776 ABSTRACT
| PDF |
Supplemental
| News |
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Walker MJ, Brouwer S, Forde BM, Worthing
KA, McIntyre L, Sundac L, Maloney S, Roberts LW, Barnett TC,
Richter J, Cork AJ, Irwin AD, You Y, Zhang J, Dougan G, Yuen
KY, Nizet V, Beatson SA, Grimwold K, Davies MR.
Detection of epidemic scarlet fever group A Streptococcus in
Australia. Clin Infect Dis 2019;
69:1232-1234. ABSTRACT
| PDF |
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Huang YM, Munguia J, Miao Y, Nizet V., McCammon JA. Docking simulation and antibiotic discovery targeting the MlaC protein in Gram-negative bacteria. Chem Biol Drug Des 2019; 93:647-652. ABSTRACT | PDF |
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Meier A, Nizet V. Impact of anesthetics on
human neutrophil function. Anesth Analg
2019; 128:569-574 ABSTRACT
| PDF |
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Boeltz S, Amini P, (26 others), Nizet V,
(16 others), von Köckritz-Blickwede M, (2 others), Herrmann
M. To NET or not to NET: Current opinions and state of
the science regarding the formation of neutrophil
extracellular traps. Cell Death Differ 2019;
26:395-408. ABSTRACT
| PDF | Supplemental |
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Riestra AM, Valderrama JA, Patras KA, Booth SD, Quek X, Tsai CM, Nizet V. Trichomonas vaginalis induces NLRP3 inflammasome activation and pyroptosis in human macrophages. J Innate Immun 2019;11:86–98. ABSTRACT | PDF |
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Sakoulas G, Geriak M, Nizet V. Is a question of penicillin allergy sufficient grounds to forgo the multidimensional antimicrobial benefits of β-Lactam antibiotics? Clin Infect Dis 2019; 68:157-164. ABSTRACT | PDF |
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Escajadillo T, Nizet V. Pharmacological
targeting of pore-forming toxins as adjunctive therapy for
invasive bacterial infections. Toxins
2018; 10:542. ABSTRACT
| PDF |
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Vrbanac A, Riestra A, Coady A, Knight R,
Nizet V, Patras KA. The murine vaginal microbiota and
perturbation by the human pathogen group B Streptococcus.
BMC Microbiol 2018; 18:197. ABSTRACT
| PDF
| Supplemental
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Uchiyama S, Dahesh S, Nizet V, Kessler J.
Enhanced topical delivery of non-complexed molecular iodine
for methicillin-resistant Staphylococcus aureus decolonization.
Int J Pharmaceut 2018; 554:81-86 ABSTRACT
| PDF |
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van Hensbergen VP, Movert E, de Maat V, Le
Breton Y, Lambeau G, Payre C, Kahn F, Henningham A, Nizet V,
Van Strijp JA, Carlsson F, McIver KS, van Sorge NM.
Streptococcal Lancefield polysaccharides are critical cell
wall determinants for human group IIA secreted phospholipase
A2 to exert its bactericidal effects. PLoS
Pathogens 2018; 14:e1007348. ABSTRACT
| PDF | Supplemental |
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Coady A, Ramos AR, Olson J, Nizet V,
Patras KA. Tamm-Horsfall protein protects the urinary
tract against Candida albicans. Infect
Immun 2018; 86: e00451-18. ABSTRACT
| PDF |
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Kavvas E, Catoiu E, Mih N, Yurkovich J,
Seif Y, Dillon N, Heckmann D, Anand A, Yang L, Nizet V, Monk
J, Palsson BO. Machine learning and structural analysis of Mycobacterium
tuberculosis pan-genome identifies genetic signatures
of antibiotic resistance. Nat Commun 2018;
9:4306. ABSTRACT
| PDF | Supplemental |
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Yang WH, Heithoff DM, Aziz P,
Haslund-Gourney B, Westman JS, Narisawa S, Pinkerton AB,
Millan JL, Nizet V, Mahan MJ, Marth JD. Accelerated
aging and clearance of host anti-inflammatory enzymes by
discrete pathogens fuels sepsis. Cell Host Microbe
2018; 24:500-513. ABSTRACT
| PDF |
Supplemental
| Press
Release |
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Fong J, Tsai CM, Nizet V, Varki A, Bui
J. Siglec-7 Engagement by GBS β-protein suppresses
pyroptotic cell death of natural killer cells. Proc
Natl Acad Sci USA 2018; 115:10410-10415. ABSTRACT
| PDF | Supplemental |
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Alisson-Silva F, Liu J, Diaz S, Deng L,
Gareau M, Chen X, Nizet V, Varki N, Barrett K, Varki A.
Human evolutionary loss of epithelial Neu5Gc expression and
the species-specific susceptibility to cholera. PLoS
Pathogens 2018; 14:e1007133. ABSTRACT
| PDF |
Supplemental |
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Askarian F, Wagner T, Johannessen M, Nizet
V. Staphylococcus aureus modulation of innate immune
responses through Toll-like (TLR), (NOD)-like (NLR)
and C-type lectin (CLR) receptors. FEMS Microbiol
Rev 2018; 42:656-671 ABSTRACT
| PDF |
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Patras KA, Derieux J, Al-Bassam MM,
Adiletta N, Vrbanac A, Lapek JD, Zengler K, Gonzalez DJ,
Nizet V. Group B Streptococcus biofilm regulatory
protein A contributes to bacterial physiology and innate
immune resistance. J Infect Dis 2018;
218:1641-1652. ABSTRACT
| PDF | Supplemental |
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Kumaraswamy M, Collignon S, Do C, Kim J,
Nizet V, Friend J. Decontaminating surfaces with atomized
disinfectants generated by a novel thickness-mode lithium
niobate device. Appl Microbiol Biotechnol
2018; 102:6459-6467 ABSTRACT
| PDF | Supplemental |
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Soderholm AT, Barnett TC, Korn O,
Hernandez TR, Seymour LM, Schulz BL, Nizet V, Wells CA,
Sweet MJ, Walker MJ. Group A Streptococcus M1T1
intracellular infection of primary tonsil epithelial cells
dampens levels of secreted IL-8 through the action of
SpyCEP. Front Cell Infect Microbiol 2018;
8:160. ABSTRACT
| PDF |
Supplemental |
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Gupta N, Nizet V. Stabilization of hypoxia-inducible factor 1-alpha augments the therapeutic capacity of bone marrow-derived mesenchymal stem cells in experimental pneumonia. Front Med 2018; 5:131. ABSTRACT | PDF | Supplemental |
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van den Broek MFL, De Boeck I, Claes IJJ,
Nizet V, Lebeer S. Multifactorial inhibition of lactobacilli
against the respiratory tract pathogen Moraxella
catarrhalis. Benef Microbes 2018;
9:429-439. ABSTRACT
| PDF |
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Jati S, Kundu S, Chakraborty A, Mahata SK,
Nizet V, Sen M. Wnt5A signaling promotes defense
against bacterial pathogens by activating a host autophagy
circuit. Front Immunol 2018; 9:679. ABSTRACT
| PDF |
Supplemental |
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Monogue M, Sakoulas G, Nizet V, Nicolau
D. Humanized exposures of a β-lactam-β-lactamase
inhibitor, tazobactam, versus non-β-lactam-β-lactamase
inhibitor, avibactam, with or without colistin, against Acinetobacter
baumannii in murine thigh and lung infection models.
Pharmacology 2018; 101:255-261.
ABSTRACT
| PDF |
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Gupta N, Liu R, Shin S, Sinha R, Pogliano
J, Pogliano K, Griffin JH, Nizet V, Corriden R.
SCH79797 improves outcomes in experimental bacterial
pneumonia by boosting neutrophil killing and direct
antibiotic activity. J Antimicrob Chemother 2018;
73:1586-1594. ABSTRACT
| PDF | Supplemental |
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Patras KA, Nizet V. Group B streptococcal
maternal colonization and neonatal disease: molecular
mechanisms and preventative approaches. Front
Pediatr 2018; 6:27. ABSTRACT |
PDF |
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Haripriyan J, Omanakuttan A, Menon ND,
Vanuopadath M, Sadassivan Nair S, Corriden R, Nair BG, Nizet
V, Kumar GB. Clove bud oil modulates pathogenicity
phenotypes of the opportunistic human pathogen Pseudomonas
aeruginosa. Sci Rep 2018; 8:3437. ABSTRACT
| PDF
|
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Askarian F, Lapek JD, Tsai CM, Kumaraswamy
M, Kousha A, Valderrama JA, Ludviksen JA, Cavanagh PJ,
Uchiyama S, Mollnes TE, Gonzalez DJ, Wai SN, Nizet V,
Johannessen M. Staphylococcus aureus
membrane-derived vesicles promote bacterial virulence and
confer protective immunity in murine infection models. Front
Microbiol 2018; 9:262. ABSTRACT |
PDF |
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Chen Y, Chen M, Zhang Y, Lee JH,
Escajadillo T, Gong H, Fang RH, Gao W, Nizet V, Zhang
L. Broad-spectrum neutralization of pore-forming
toxins with human erythrocyte membrane-coated
nanosponges. Adv Health Mater 2018;
7:e1701366. ABSTRACT
| PDF |
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Lawrence SM, Corriden R, Nizet V.
The ontogeny of a neutrophil: mechanisms of granulopoiesis
and homeostasis. Microbiol Mol Biol Rev
82:e00057-17. ABSTRACT
| PDF |
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Gupta N, Sinha R, Krasnodembskaya A, Xu X,
Nizet V, Matthay MA, Griffin JH. The TLR4-PAR1 axis
regulates bone marrow mesenchymal stromal cell survival and
therapeutic capacity in experimental bacterial pneumonia. Stem
Cells 2018; 36:796-806. ABSTRACT
| PDF |
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Choe D, Szubin R, Dahesh
S, Cho; S, Nizet V, Palsson BO, Cho BK. Genome-scale
analysis of methicillin-resistant Staphylococcus aureus
USA300 reveals a tradeoff between pathogenesis and
drug resistance. Sci Rep 2018; 8:2215. ABSTRACT
| PDF |
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Kumaraswamy M, Do C, Sakoulas G, Nonejuie
P, Tseng GW, King H, Fierer J, Pogliano J, Nizet V. Listeria
monocytogenes endocarditis: Case report, review of
the literature, and laboratory evaluation of potential novel
antibiotic synergies. Int J Antimicrob Agents
2018; 51:468-478. ABSTRACT
| PDF
| Supplemental
|
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Henningham A, Davies MR, Uchiyama S, Van
Sorge NM, Lund S, Bannon K, Walker MJ, Cole JN, Nizet
V. Virulence role of the GlcNAc side-chain of the
Lancefield cell wall carbohydrate antigen in non-M1 serotype
group A Streptococcus. mBio 2018;
9:e02294-17. ABSTRACT
| PDF |
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Liu JZ, Ali SR, Bier E, Nizet V.
Innate immune interactions between Bacillus anthracis
and host neutrophils. Front Cell Infect Microbiol
2018; 8:2. ABSTRACT
| PDF
| Supplemental |
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Valderrama JA, Nizet V. Group A Streptococcus encounters with host macrophages. Future Microbiol 2018; 13:119-134. ABSTRACT | PDF |
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Mesci P, Macia A, LaRock CN, Tejwani L, Fernandes IR, Suarez NA, Zanotto PM, Beltrão-Braga PC, Nizet V, Muotri AR. Modeling neuro-immune interactions during Zika virus infection. Human Mol Genet 2018; 27:41-52. ABSTRACT | PDF |
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Andreoni, F, Ugolini F, Keller N, Neff A, Nizet V, Hollands A, Marques-Maggio E, Zinkernagel A, Schuepbach R. Immunoglobulin attenuates streptokinase-mediated virulence in Streptococcus dysgalactiae subsp. equisimilis necrotizing fasciitis. J Infect Dis 2018; 217:270-279. ABSTRACT | PDF |
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Mascuch SJ, Boudreau PD, Carland TM, Pierce NT, Olson J, Hensler ME, Choi H, Campanale J, Hamdoun A, Nizet V, Gerwick WH, Gaasterland T, Gerwick L. The marine natural product honaucin A attenuates inflammation by activating the Nrf2-ARE pathway. J Nat Prod 2018; 81:506-514 ABSTRACT | PDF | Supplemental |
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Reynolds KA, Luhavaya H, Li J, Dahesh S, Nizet V, Moore BS. Isolation and structure elucidation of lipopeptide antibiotic taromycin B from the activated taromycin biosynthetic gene cluster. J Antibiot 2018;71:333-338 ABSTRACT | PDF |
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Britt N, Tirmizi S, Ritchie D, Topal J, McManus D, Nizet V, Casabar E, Sakoulas G. Telavancin for refractory methicillin-resistant Staphylococcus aureus bacteremia in intermittent hemodialysis recipients. J Antimicrob Chemother 2017; 73: 764-767. ABSTRACT | PDF |
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Yang WH, Heithoff DM, Aziz PV, Sperandio
M, Nizet V, Mahan MJ, Marth JD. Recurrent Salmonella
infection progressively disables host protection against
intestinal inflammation. Science 2017;
358:eaao5610.
ABSTRACT | PDF
| Supplemental
| Press
Release | Blog Post |
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Catteau L, Reichmann NT, Olson J, Pinho M,
Nizet V, van Bambeke F, Quetin-LeClercq J. Synergy
between ursolic and oleanolic acids from Vitellaria paradoxa
leaf extract and β-lactams against methicillin-resistant Staphylococcus
aureus: in vitro and in vivo activity
and underlying mechanisms. Molecules 2017;
22:2245. ABSTRACT
| PDF |
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Sakoulas G, Kumaraswamy M, Kousha A, Nizet
V. Interaction of antibiotics with innate host defense
factors against Salmonella enterica serotype
Newport. mSphere 2017;
2:e00410-17. ABSTRACT
| PDF |
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Zhang Y, Gao W, Chen Y, Escajadillo T,
Ungerleider JL, Fang RH, Christman KL, Nizet V, Zhang L.
Self-assembled colloidal gel using cell membrane-coated
nanosponges as building blocks. ACS Nano 2017;
11:11923-11930. ABSTRACT
| PDF |
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Thamphiwatana S*, Angsantikul P*,
Escajadillo T*, Zhang Q, Olson J, Luk BT, Zhang S, Fang RH,
Gao W, Nizet V, Zhang L. Macrophage-like nanoparticles
concurrently absorbing endotoxins and proinflammatory
cytokines for sepsis management. Proc Natl Acad
Sci USA 2017; 114:11488-11493. ABSTRACT
| PDF |
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Guichard A, Jain P, Moayeri M, Schwarz R,
Chin S, Zhu L, Cruz-Moreno B, Liu JZ, Aguilar B, Hollands A,
Leppla SH, Nizet V, Bier E. Anthrax edema toxin
disrupts distinct steps in Rab11-dependent junctional
transport. PLoS Pathog 2017;
13:e1006603. ABSTRACT
| PDF | Supplemental |
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Sun J, Lei L, Tsai CM, Wang Y, Shi Y,
Ouyang M, Lu S, Seong J, Kim T, Wang P, Huang M, Xu X, Nizet
V, Chien S, Wang Y. Engineered proteins with sensing and
activating modules for automated reprogramming of cellular
functions. Nat Commun 2017; 8:477. ABSTRACT
| PDF
| Supplemental
| Movie
1 | Movie
2 | Movie
3 | Movie
4 |
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Munguia J, LaRock D, Tsunemoto H, Olson J,
Cornax I, Pogliano J, Nizet V. The Mla pathway is critical
for Pseudomonas aeruginosa resistance to outer
membrane permeabilization and host innate immune clearance.
J Mol Med 2017; 95:1127–1136. ABSTRACT
| PDF |
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Patras KA, Coady A, Olson J, Ali SR,
RamachandraRao S, Varki A, Nizet V. Tamm-Horsfall
glycoprotein engages human Siglec-9 to modulate neutrophil
activation in the urinary tract. Immunol Cell Biol
2017; 95:960-965. ABSTRACT
| PDF |
Supplemental |
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Valderrama JA, Riestra A, Gao NJ, LaRock
CN, Gupta N, Ali SR, Hoffman HM, Ghosh P, Nizet V.
Group A streptococcal M protein activates the NLRP3
inflammasome. Nat Microbiol 2017;
2;1425–1434. ABSTRACT
| PDF | Supplemental | Commentary
| Press
Release | NBC
7 News | KUSI
News |
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Escajadillo T, Olson J, Luk BT, Zhang L,
Nizet V. A red blood cell membrane-camouflaged
nanoparticle counteracts streptolysin O‑mediated virulence
phenotypes of invasive group A Streptococcus.
Front Pharmacol 2017; 8:477. ABSTRACT
| PDF |
Supplemental |
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Schooley R, Biswas B, Gill JJ,
Hernandez-Morales A, Lancaster J, Lessor L, Barr JJ, Reed
SL, Rohwer F, Benler S, Segall AM, Taplitz R, Smith DM, Kerr
K, Kumaraswamy M, Nizet V, Lin L, McCauley MD, Strathdee SA,
Benson CA, Leroux BM, Pope RK, Picel AC, Mateczun AJ,
Cilwa KE, Regeimbal JM, Estrella LA, Wolfe DM, Henry MS,
Quinones J, Salka S, Bishop-Lilly KA, Young R, Hamilton T.
Development and use of personalized bacteriophage-based
therapeutic cocktails to treat a patient with a disseminated
resistant Acinetobacter baumannii infection. Antimicrob
Agents Chemother 2017; 61:e00954-17. ABSTRACT
| PDF |
Supplemental
| The
Amazing Story |
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Lin AE, Autran CA, Szyszka A, Escajadillo
T, Huang M, Godula K, Prudden AR, Boons GJ, Lewis AL, Doran
KS, Nizet V, Bode L. Human milk oligosaccharides inhibit growth of group B Streptococcus. J Biol Chem 2017; 92;11243–11249. ABSTRACT | PDF |
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Nizet V. The accidental orthodoxy of
Drs. Mueller and Hinton. EBiomedicine
2017;22:26-27 PDF |
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Severino P, Ariga SK, Barbeiro HV, de Lima
TM, de Paula Silva E, Barbeiro DF, Machado MC, Nizet V,
Pinheiro da Silva F. Cathelicidin-deficient mice
exhibit increased survival and upregulation of key
inflammatory response genes following cecal ligation and
puncture. J Mol Med 2017;
95:995–1003. ABSTRACT
| PDF |
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Lizcano A, Secundino I, Döhrmann S,
Corriden R, Deng L, Diaz S, Nizet V, Varki A. Erythrocyte
sialoglycoproteins engage Siglec-9 on neutrophils to
suppress activation. Blood 2017;
29:3100-3110. ABSTRACT
| PDF |
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Munguia J, Nizet V. Pharmacological
targeting of the host-pathogen interaction: Alternatives to
classical antibiotics to combat drug-resistant
superbugs. Trend Pharm Sci 2017;
38:473-488. ABSTRACT
| PDF |
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Lawrence SM, Corriden R, Nizet V. Age-appropriate functions and dysfunctions of the neonatal neutrophil. Front Pediatr 2017; 5:23. ABSTRACT | PDF |
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Caffrey AR, Timbrook T, Noh E, Sakoulas G,
Opal SM, Nizet V, LaPlante KL. Evidence to support
continuation of statin therapy in patients with Staphylococcus
aureus bacteremia. Antimicrob Agents Chemother
2017; 61:e02228-16. ABSTRACT
| PDF
| Supplemental |
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Döhrmann S, LaRock CN, Anderson EL, Cole
JN, Ryali B, Stewart C, Nonejuie P, Pogliano J, Corriden R,
Ghosh P, Nizet V. Group A streptococcal M1
protein provides resistance against the antimicrobial
activity of histones. Sci Rep 2017; 7:43039. ABSTRACT
| PDF | Supplemental |
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Rose WE, Berti AD, Hayney MS, Henriquez K,
Ranzoni A, Cooper MA, Skukla SK, Proctor RA, Nizet V,
Sakoulas G. Increased endovascular Staphylococcus aureus
inoculum is the link between elevated serum IL-10
concentrations and mortality in patients with
bacteremia. Clin Infect Dis 2017;
64:1406-1412. ABSTRACT
| PDF |
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Sakoulas G, Rose W, Berti A, Olson J,
Munguia J, Nonejuie P, Sakoulas E, Rybak MJ, Pogliano J,
Nizet V. Classical β-lactamase inhibitors potentiate
the activity of daptomycin against methicillin-resistant Staphylococcus
aureus and colistin against Acinetobacter
baumannii. Antimicrob Agents Chemother 2017;
61: e01745-16. ABSTRACT
| PDF |
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Okerblom J, Schwarz F, Olson J, Fletes W,
Ali SR, Martin PT, Glass CK, Nizet V, Varki A. Loss of CMAH
during human evolution primed the monocyte-macrophage
lineage towards a more inflammatory and phagocytic
state. J Immunol 2017;
198:2366-2373. ABSTRACT
| PDF |
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De Oliveira DM, Hartley-Tassel L,
Everest-Dass A, Day CJ, Dabbs R, Ve T, Kobe B, Nizet V,
Packer NH, Walker MJ, Jennings MP, Sanderson-Smith ML. Blood
group antigen recognition via the group A streptococcal M
protein mediates host colonization. mBio 2017;
8:e02237-16. ABSTRACT
| PDF |
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Schwarz F, Landig C, Siddiqui S, Secundino
I, Garcia-Bingman A, Olson J, Varki N, Nizet V, Varki
A. Paired Siglec receptors generate opposite
inflammatory responses to a human-specific pathogen. EMBO
J 2017; 36:751-760. ABSTRACT
| PDF |
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van Wijk XM, Döhrmann S, Voldborg BG, Hallström BM, Li S, Meng BX, McKee KK, van Kuppevelt TH, Yurchenco PD, Palsson BO, Lewis NE, Nizet V, Esko JD. Whole genome sequencing of invasion-resistant cells identifies laminin alpha 2 as a host factor for bacterial invasion. MBio 2017; 8:e02128-16. ABSTRACT | PDF |
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Storisteanu DM, Pocock JM, Cowburn AS,
Juss JK Nadesalingam A, Nizet V, Chilvers ER. Evasion
of neutrophil extracellular traps by respiratory
pathogens. Am J Respir Cell Mol Biol
2017;56:423-431. ABSTRACT |
PDF |
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Arnold JC, Nizet V. Chapter 27:
Pharyngitis, pp. 202-208 and Nizet V, Arnold JC. Chapter
118: Streptococcus pyogenes (group A Streptococcus),
pp. 715-723. In: Principles and Practices of Pediatric
Infectious Diseases, 5th Edition (S Long, CG Prober, Fischer
M, eds.). Elsevier, Philadelphia, 2017. Pharyngitis PDF
| GAS PDF |
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Nizet V, Varki A, Aebi M. Microbial
lectins: hemagglutinins, adhesins, and toxins. In: Varki A,
Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Darvill
AG, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL,
Seeberger PH, editors. Essentials of Glycobiology
[Internet]. 3rd edition. Cold Spring Harbor Laboratory
Press. Chapter 37. ABSTRACT
| Full
Text |
| 2 0 1 6 | |
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Sorg RA, Lin L, van Doorn S, Sorg M, Olson
J, Nizet V, Veening JW. Collective resistance in
microbial communities by intracellular antibiotic
deactivation. PLoS Biol 2016;
14:e2000631. ABSTRACT
| PDF |
Supplemental |
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Coady A, Nizet V. SAMP-ening down
sepsis. Ann Transl Med 2016; 4:509. ABSTRACT
| PDF |
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Flores R, Döhrmann S, Schaal C, Hakkim A,
Nizet V, Corriden R. The selective estrogen receptor
modulator raloxifene inhibits neutrophil extracellular trap
formation. Front Immunol 2016;
7:566. ABSTRACT
| PDF |
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Askarian F, Uchiyama S, Valderrama JA,
Ajayi C, Sollid JE, van Sorge NM, Nizet V, van Strijp JA,
Johannessen M. Serine-aspartate-repeat protein D
increases Staphylococcus aureus virulence and
survival in blood. Infect Immun 2016;
85:e00559-16 ABSTRACT
| PDF | Supplemental |
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Buffalo CZ, Bahn-Suh AJ, Hirakis SP,
Biswas T, Amaro RE, Nizet V, Ghosh P. Conserved
patterns hidden within group A Streptococcus M protein
hypervariability recognize human C4b-binding protein.
Nat Microbiol 2016; 1:16155. ABSTRACT
| PDF | Supplemental | Press
Release |
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Hentrich K, Löfling J, Pathak A, Nizet V,
Varki A, Henriques-Normark B. Streptococcus
pneumoniae senses a human-like sialic acid profile via
the response regulator CiaR. Cell Host Microbe
2016; 20:307-17. ABSTRACT
| PDF | Press
Release |
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Sakoulas G, Olson J, Yim J, Singh NB,
Kumaraswamy M, Quach DT, Rybak MJ, Pogliano J, Nizet V.
Cefazolin and ertapenem: A synergistic combination used to
clear persistent Staphylococcus aureus
bacteremia. Antimicrob Agents Chemother 2016;
60:6609-6618. ABSTRACT
| PDF |
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LaRock CN, Todd J, LaRock D, Olson J,
O’Donoghue AJ, Robertson AA, Cooper MA, Hoffman HM,
Nizet V. IL-1β is an innate immune sensor of microbial
proteolysis. Sci Immunol 2016;
1:eaah3539. ABSTRACT
| PDF | Supplemental | Invited Commentary
| Interview
|
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Stewart C, Valderamma JA, Henningham A,
Cole JN, Nizet V, Ghosh P. Coiled-coil
destabilizing residues in the group A Streptococcus
M1 protein are required for functional interaction. Proc
Natl Acad Sci USA 2016; 13:9515-20. ABSTRACT
| PDF | Supplemental |
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Sganappa A, Bellucci MC, Nizet V, Tor Y,
Volonterio A. Multicomponent domino synthesis and
antibacterial activity of neomycin-sugar conjugates. Synthesis
2016; 48: 4443-4450. ABSTRACT
| PDF |
Supplemental |
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Döhrmann S, Cole JN, Nizet V.
Conquering neutrophils. PLoS Pathog 2016;
12:e1005682. ABSTRACT
| PDF |
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Makoni M, Eckert J, Pereira HA, Nizet V,
Lawrence SM. Alterations in neonatal neutrophil
function attributable to increased immature forms. Early
Hum Dev 2016; 103:1-7. ABSTRACT
| PDF |
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Yamaguchi M, Hirose Y, Nakata M, Uchiyama
S, Yamaguchi Y, Goto K, Sumitomo T, Lewis AL, Kawabata S,
Nizet V. Evolutionary inactivation of a sialidase in
group B Streptococcus. Sci Rep 2016; 6:
28852. ABSTRACT
| PDF | Supplemental |
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Bosil E, Monk J, Aziz RK, Fondi M, Nizet
V. Palsson BO. Comparative genome-scale modeling of
multiple Staphylococcus aureus strains identifies
unique metabolic capabilities linked to pathogenicity.
Proc Natl Acad Sci USA 2016; 13:E3801-9. ABSTRACT
| PDF |
Press
Release |
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Rivera-Hernandez T, Pandey M, Henningham
A, Cole JN, Choudhury B, Walker A, Duplanic C, Abdul Ghaffar
K, West NP, Silvestri G, Good M, Moyle P, Toth I, Nizet V,
Batzloff M, Walker MJ. Differing efficacy of lead
group A streptococcal vaccine candidates and full-length M
protein in cutaneous and invasive disease models. mBio
2016; 7:e00618-16. ABSTRACT
| PDF |
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Carey AJ, Weinberg JB, Dawid SR, Venturini
C, Lam AK, Nizet V, Caparon M, Walker MJ, Watson ME, Ulett
GC. Interleukin-17A controls Streptococcus
pyogenes colonization and inflammation of the female
genital tract. Sci Rep 2016; 6:26836. ABSTRACT
| PDF |
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Le J, Dam Q, Schweizer M, Thienphrapa W,
Nizet V, Sakoulas G. Effects of vancomycin versus
nafcillin in enhancing killing of methicillin-susceptible Staphylococcus
aureus bacteremia by human cathelicidin LL-37. Eur
J Clin Microbiol Infect Dis 2016;
35:1441-1447. ABSTRACT
| PDF |
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Hollands A, Corriden R, Gysler G, Dahesh
S, Olson J, Kunkel MT, Lin AE, Forli S, Newton AC, Kumar GB,
Nair BG, Perry JJP, Nizet V. Natural product anacardic acid
from cashew nut shells stimulates neutrophil extracellular
trap production and bactericidal activity. J Biol
Chem 2016; 291:13964-13973. ABSTRACT
| PDF | Blog
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Lin L, Kim J, Chen H, Nizet V.
Component analysis of multi-purpose contact lens solutions
to enhance activity against Pseudomonas aeruginosa
and Staphylococcus aureus. Antimicrob
Agents Chemother 2016; 60:4259-4263. ABSTRACT
| PDF | Supplemental
| Local
News Story |
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Huang YM, Miao Y, Munguia J, Lin L, Nizet
V, McCammon JA. Molecular dynamic study of MlaC protein in
Gram-negative bacteria: conformational flexibility, solvent
effect and protein-phospholipid binding. Protein
Sci 2016; 25:1430-1437. ABSTRACT
| PDF |
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Völlger L, Akong-Moore KA, Cox L,
Goldmann O, Wang Y, Schäfer S, Naim H, Nizet V, von
Köckritz-Blickwede M. Iron chelating agent desferrioxamine
stimulates formation of neutrophil extracellular traps
(NETs) in human blood-derived neutrophils. Biosci
Rep 2016; 36:e00333. ABSTRACT
| PDF |
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von Köckritz-Blickwede M, Blodkamp S,
Nizet V. Interaction of bacterial exotoxins with neutrophil
extracellular traps: impact for the infected host. Front
Microbiol 2016; 7:402. ABSTRACT
| PDF |
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Kumaraswamy M, Lin L, Olson J, Sun C-F,
Nonejuie P, Corriden R, Döhrmann S, Ali SR, Amara D, Rohde
M, Pogliano J, Sakoulas G, Nizet V. Standard
susceptibility testing masks potent azithromycin activity
and cationic peptide synergy against multidrug-resistant Stenotrophomonas
maltophilia. J Antimicrob Chemother
2016; 71:1264-9. ABSTRACT
| PDF Supplemental |
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Cole JN, Nizet V. Bacterial evasion of
host antimicrobial peptide defenses. Microbiol Spectrum
2016; 4:VMBF- 0006-2015. ABSTRACT
| PDF |
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Quach DT, Sakoulas G, Nizet V, Pogliano J,
Pogliano K. Bacterial cytological profiling (BCP) as a rapid
and accurate antimicrobial susceptibility testing method for
Staphylococcus aureus. eBiomedicine 2016; 4:
95-103. ABSTRACT
| PDF | Press
Release |
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Berti AD, Theisen E, Demain-Sauer J,
Nonejuie N, Olson J, Pogliano J, Sakoulas G, Nizet V,
Proctor RA, Rose WE. Penicillin binding protein 1 is
important in the compensatory response of Staphylococcus
aureus to daptomycin-induced membrane damage and is a
potential target for β-lactam-daptomycin synergy. Antimicrob
Agents Chemother 2016; 60:451-458. ABSTRACT
| PDF | Supplemental |
| 2 0 1 5 | |
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Kolar S, Kyme P, Tseng CW, Soliman A,
Kaplan A, Liangó J, Nizet V, Jiang D, Murali R, Arditi M,
Underhill DM, Liu GY. Group B Streptococcus
evades host immunity by degrading hyaluronan. Cell
Host Microbe 2015; 18:694-704. ABSTRACT
| PDF
| Cover Image |
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Uchiyama S, Döhrmann S, Timmer AM, Dixit
N, Ghochani M, Bhandari T, Timmer JC, Sprague K,
Bubeck-Wardenburg J, Simon SI and Nizet V (2015)
Streptolysin O rapidly impairs neutrophil oxidative burst
and antibacterial responses to group A Streptococcus.
Front Immunol 2015; 6:581. ABSTRACT
| PDF |
Supplemental |
|
LaRock CN, Döhrmann S, Todd J, Corriden R,
Olson J, Johannssen T, Lepenies B, Gallo RL, Ghosh P, Nizet
V. Group A streptococcal M1 protein sequesters
cathelicidin to evade immune killing. Cell Host Microbe
2015; 18:471-477. ABSTRACT
| PDF | Commentary | Press
Release |
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Corriden R, Hollands A, Olson J, Derieux
J, Lopez JM, Gonzalez DJ, Nizet V. Tamoxifen augments the
innate immune function of neutrophils through modulation of
intracellular ceramide. Nat Comm 2015;
6:8369. ABSTRACT
| PDF |
Supplemental
| Press
Release | Union-Tribune
| Huffington
Post | Washington
Post |
|
Fong JJ, Sreehara K, Deng L, Varki NM,
Angata T, Liu Q, Nizet V, Varki A. Immunomodulatory
activity of extracellular Hsp70 mediated via paired
receptors Siglec-5 and Siglec-14. EMBO J 2015;
34:2775-88. ABSTRACT
| PDF | Graphical Abstract |
|
LaRock CN, Nizet V. Inflammasome/IL-1β
responses to streptococcal pathogens. Front
Immunol 2015; 6:518. ABSTRACT
| PDF |
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Barnett T, Cole JN, Rivera Hernandez T,
Henningham A, Paton J, Nizet V, Walker MJ. Streptococcal
toxins: role in pathogenesis and disease. Cell Microbiol
2015; 17:1721-41. ABSTRACT
| PDF |
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Secundino I, Lizcano A, Roupé KM, Wang X,
Cole JN, Ali SR, Dahesh S, Amayreh LK, Henningham A, Varki
A, Nizet V. Host and pathogen hyaluronan signal
through human Siglec-9 to suppress neutrophil activation.
J Mol Med 2015; 94:219-33. ABSTRACT
| PDF |
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Grimsey NJ, Aguilar B, Smith TH, Le PN,
Soohoo A, Puthenveedu MA, Nizet V, Trejo J. Ubiquitin
plays an atypical role in GPCR-induced p38 MAP kinase
activation on endosomes. J Cell Biol 2015;
210:1117-1131. ABSTRACT
| PDF |
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Pence MA, Haste NM, Sabhatu HM, Olson J,
Gallo RL, Nizet V, Kristian SA. Beta-lactamase
repressor BlaI modulates Staphylococcus aureus
cathelicidin antimicrobial peptide resistance and virulence.
PLoS One 2015; 10:e0136605 ABSTRACT
| PDF |
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Sakoulas G, Kumaraswamy M, Nonejuie P,
Werth B, Rybak MJ, Pogliano J, Rice LB, Nizet V.
Differential effects of penicillin-binding protein deletion
on the susceptibility of Enterococcus faecium to
cationic peptide antibiotics. Antimicrob Agents Chemother
2015; 59(10):6132-9. ABSTRACT
| PDF |
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Nizet V. Stopping superbugs,
maintaining the microbiota. Sci Transl Med
2015; 7:295ed8. PDF
| Banner |
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Xu D, Olson J, Cole JN, van Wijk XM,
Brinkmann V, Zychlinsky A, Nizet V, Esko JD, Chang
YC. Heparan sulfate modulates neutrophil and
endothelial function in antibacterial innate immunity.
Infect Immun 2015; 83:3648-3656. ABSTRACT
| PDF |
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Lin L, Nonejuie P, Munguia J, Hollands A,
Olson J, Dam Q, Kumaraswamy M, Rivera H, Corriden R, Rohde
M, Hensler ME, Burkart MD, Pogliano J, Sakoulas G,
Nizet V. Azithromycin synergizes with cationic antimicrobial
peptides to exert bactericidal and therapeutic activity
against highly multidrug-resistant Gram-negative bacterial
pathogens. eBiomedicine 2015; 2:690–698. ABSTRACT
| PDF | Supplemental
| Commentary
| Press
Release | UT-San
Diego | DDD
Magazine |
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Holden JK, Kang S, Beasley FC, Cinelli MA,
Li H, Roy SG, Dejam D, Edinger AL, Nizet V, Silverman RB,
Poulos TL. Nitric oxide synthase as a target for
methicillin-resistant Staphylococcus aureus. Chem
Biol 2015; 22;785–792. ABSTRACT
| PDF
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Hindler J, Wong-Beringer A, Charlton C,
Campeau Miller S, Kelesidis T, Carvalho M, Sakoulas G,
Nonejuie P, Pogliano J, Nizet V, Humphries R. In vitro
activity of daptomycin in combination with β-lactams,
gentamicin, rifampin and tigecycline against daptomycin
non-susceptible enterococci. Antimicrob Agents
Chemother 2015; 59:4279-8. ABSTRACT
| PDF |
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Kristian SA, Hwang JH, Hall B, Liere
E, Iacomini J, Old R, Galili U, Roberts C, Mullis KB, Westby
M, Nizet V. Retargeting pre-existing human antibodies to a
bacterial pathogen with an alpha-Gal conjugated
aptamer. J Mol Med 2015; 93:619-31. ABSTRACT
| PDF | Supplemental | Press
Release | Drug Dev
News | Biocentury
|
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Awakawa T, Crüsemann M, Munguia J, Ziemer
N, Nizet V, Fenical W, Moore BS. Salinipyrone and
pacificanone are biosynthetic byproducts of the rosamicin
polyketide synthase. ChemBioChem 2015;
16:1443-7. ABSTRACT
| PDF | Supplemental |
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Lin AE, Beasley FC, Olson J, Keller N,
Shalwitz RA, Hannan TJ, Hultgren SJ, Nizet V. Hypoxia
inducible factor-1α (HIF-1α) regulates host defense against
urinary tract infection. PLoS Pathog 2015; 11:
e1004818. ABSTRACT
| PDF | Supplemental | Press
Release | TIME
Magazine |
|
McEachern EK, Hwang JH, Sladewski KM,
Nicatia S, Dewitz C, Mathew D, Nizet V, Crotty Alexander LE.
Analysis of the effects of cigarette smoke on staphylococcal
virulence phenotypes. Infect Immun 2015;
83:2443-52. ABSTRACT
| PDF | Supplemental |
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Harbut MB, Vilcheze C, Luo X, Hensler ME,
Guo H, Yang B, Chatterjee AK, Nizet V, Jacobs WR, Shultz PG,
Wang F. Auranofin exerts broad-spectrum bactericidal
activities by targeting thiol-redox homeostasis. Proc
Natl Acad Sci USA 2015; 112:4453-8. ABSTRACT
| PDF |
Supplemental |
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Lin AE, Beasley FC, Keller N, Hollands A,
Urbano R, Troemel ER, Hoffman HM, Nizet V. Group A Streptococcus
ADP-ribosyltransferase toxin SpyA stimulates a protective
IL-1β-dependent macrophage immune response. mBio
2015; 6:e00133-15 ABSTRACT
| PDF | Supplemental |
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Shalova IN, Lim JY, Chittezhath M,
Zinkernagel AS, Beasley F, Hernández-Jiménez E, Toledano
V, Rapsardi A, Chen J, Kaibo D, Yang H, Poidinger M, Melillo
G, Nizet V, Arnalich F, Lopez-Collazo E, Biswas SK. Human
monocytes undergo functional re-programming during sepsis
mediated by hypoxia-inducible factor-1α. Immunity
2015; 42:484-98. ABSTRACT
| PDF |
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Berti AD, Baines SL, Howden BP, Sakoulas
G, Nizet V, Proctor RA, Rose WE. Heterogeneity of
genetic pathways toward daptomycin nonsusceptibility in Staphylococcus
aureus determined by adjunctive antibiotics. Antimicrob
Agents Chemother 2015; 59:2799 –806. ABSTRACT
| PDF |
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LaRock CN, Nizet V. Cationic
antimicrobial peptide resistance mechanisms of streptococcal
pathogens. Biochem Biophys Acta 2015
1848:3047-54. ABSTRACT
| PDF |
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Matak P, Heinis M, Mathieu JR, Corriden R,
Delga S, Rouquette A, Mounier R, Raymond J, Lamarque D,
Emile JF, Nizet V. Touati E, Peyssonnaux C. Myeloid
HIF-1 is protective in H. pylori-mediated
gastritis. J Immunol 2015; 194:3259-66.
ABSTRACT
| PDF | Supplemental |
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Bier E, Nizet V. Hedgehog: Linking
uracil to innate defense. Cell Host Microbe
2015; 17:146-158. ABSTRACT
| PDF |
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Henningham A, Döhrmann S, Nizet V, Cole
JN. Mechanisms of group A Streptococcus resistance
to reactive oxygen species. FEMS Microbiol Rev
2015; 39:488-508. ABSTRACT
| PDF |
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Ali SR, Karin M, Nizet V. Signaling cascades and inflammasome activation in microbial infections. Inflammasome 2015; 2:7–12. ABSTRACT | PDF |
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Patel V, Carrion K, Hollands A, Hinton A,
Gallegos T, Dyo J, Sasik R, Leire E, Hardiman G, Mohamed SA,
Nigam S, King CC, Nizet V, Nigam V. The stretch responsive
microRNA miR-148a is a novel repressor of IκBkB, NF-κB
signaling, and inflammatory gene expression in human aortic
valve cells. FASEB J 2015; 29:1859-68. ABSTRACT
| PDF | Supplemental |
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Sakoulas G, Nonejuie P, Kullar R, Pogliano
J, Rybak MJ, Nizet V. Examining the use of ceftaroline
in the treatment of Streptococcus pneumoniae
meningitis with reference to human cathelicidin LL-37.
Antimicrob Agents Chemother 2015; 59:2428-31. ABSTRACT
| PDF |
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Wilkinson DS, Shah JS, Anderson E, Mitra K, Meisenhelder J, Chang JT, Ideker T, Hunter T, Nizet V, Dillin A, Hansen M. Phosphorylation of Hippo kinases STK3/STK4 is essential for autophagy. Mol Cell 2015; 57:55-68. ABSTRACT | PDF | Supplemental |
 |
Remington & Klein's Infectious
Diseases of the Fetus & Newborn Infant, 8th
Edition. Wilson CB, Nizet V, Maldonado Y, Remington J,
Klein JO. Elsevier, Philadelphia. 2015
Chapters: Current
Concepts | Bacterial Sepsis &
Meningitis | Focal
Bacterial Infections | Group B Streptococcal Infections
| Staphylococcal
Infections |
| 2 0 1 4 | |
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Gonzalez DJ, Corriden R, Akong-Moore K,
Olson J, Dorrestein PC, Nizet V. Functional properties
of N-terminal ArgD peptides from the classical Staphylococcus
aureus Agr system. Chem Biol 2014;
21:1457-1462. ABSTRACT
| PDF |
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Palazon A, Goldrath A, Nizet V, Johnson
RS. HIF transcription factors, inflammation and
immunity. Immunity 2014; 41:518-528. ABSTRACT
| PDF |
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Kang S, Watanabe M, Jacobs JC, Yamaguchi
M, Dahesh S, Nizet V, Leyh TS, Silverman RB.
Synthesis of mevalonate- and fluorinated mevalonate prodrugs
and their in vitro human plasma stability. Eur
J Med Chem 2014; 90C:448-461. ABSTRACT
| PDF |
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Henningham A, Yamaguchi M, Aziz RK,
Kuipers K, Buffalo CZ, Dahesh S, Choudhury B, Van Vleet J,
Yamaguchi Y, Seymour LM, Ben Zakour NL, He L, Smith HV,
Grimwood K, Beatson SA, Ghosh P, Walker MJ, Nizet V, Cole
JN. Mutual exclusivity of hyaluronan and hyaluronidase in
invasive group A Streptococcus. J Biol Chem
2014; 2014, 289:32303-32315. ABSTRACT
| PDF |
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Neumann A, Berends ET, Nerlich A, Molhoek
EM, Gallo RL, Meerloo T, Nizet V, Naim HY, von
Köckritz-Blickwede M. The antimicrobial peptide LL-37
facilitates the formation of neutrophil extracellular traps.
Biochem J 2014;
464:3–11.
|
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Vega VL, Crotty Alexander LE, Charles W,
Nizet V, De Maio A. Activation of the stress response in
macrophages alters the M1/M2 balance by enhancing bacterial
killing and IL-10 expression. J Mol Med 2014;
92:1305-1317. |
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Guichard A, Nizet V, Bier E.
Rab11-mediated trafficking in host-pathogen
interactions. Nat Rev Microbiol 2014;
12:624-634. ABSTRACT
| PDF |
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Döhrmann S, Anik S, Olson J, Anderson EL,
Etesami N, No H, Snipper J, Nizet V, Okumura CY. A
role for streptococcal collagen-like protein 1 (Scl-1) in
M1T1 group A Streptococcus resistance to neutrophil
extracellular traps. Infect Immun 2014;
82:4011-4020. ABSTRACT
| PDF | Supplemental |
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Schommer NN, Muto J, Nizet V, Gallo
RL. Hyaluronan breakdown contributes to immune defense
against group A Streptococcus. J Biol Chem
2014; 289:26914-21. ABSTRACT
| PDF |
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Fair RJ, McCoy LS, Hensler ME, Aguilar B,
Nizet V, Tor Y. Singly modified amikacin and
tobramycin derivatives show increased rRNA A-site binding
and higher potency against resistant bacteria. ChemMedChem
2014; 9:2164-71. ABSTRACT
| PDF
|
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Sakoulas G, Moise PA, Casapao AM, Nonejuie
P, Olson J, Okumura CY, Rybak MJ, Kullar R, Dhand A, Rose
WE, Goff DA, Bressler AM, Lee Y, Pogliano J, Johns S, Kaatz
GW, Ebright JR, Nizet V. Antimicrobial salvage therapy
for persistent staphylococcal bacteremia using daptomycin
plus ceftaroline. Clin Therap 2014; 36:1317–1333.
ABSTRACT
| PDF |
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Chang YC, Nizet V. The interplay
between Siglecs and sialylated pathogens. Glycobiology
2014; 24:818-825. ABSTRACT
| PDF |
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Neumann A*, Völlger L*, Berends ET,
Molhoek EM, Stapels DA, Midon M, Friães A, Pingoud A,
Rooijakkers SM, Gallo RL, Mörgelin M, Nizet V, Naim
HY, von Köckritz-Blickwede M. Novel role of the
antimicrobial peptide LL-37 in the protection of neutrophil
extracellular traps against degradation by bacterial
nucleases. J Innate Immun 2014;
6:860-868. ABSTRACT
| PDF |
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Bhandari T, Nizet V. HIF as a
pharmacological target for prevention and treatment of
infectious diseases. Infect Dis Ther 2014;
3:159–174. ABSTRACT
| PDF |
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Okumura CYM, Nizet V. Subterfuge and
sabotage: Evasion of host innate defenses by invasive
Gram-positive bacterial pathogens. Ann Rev
Microbiol 2014; 68:439-58. ABSTRACT
| PDF |
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van Sorge NM, Cole JN, Kuipers K, Henningham A, Aziz RK, Kasirer-Friede A, Lin L, Berends ETM, Davies MR, Dougan G, Zhang F, Dahesh S, Shaw L, Gin J, Cunningham M, Merriman JA, Hütter J, Lepenies B, Rooijakkers SHM, Malley R, Walker MJ, Shattil SJ, Schlievert PM, Choudhury B, Nizet V. The classical Lancefield antigen of group A Streptococcus is a virulence determinant with implications for vaccine design. Cell Host Microbe 2014; 15:729-740. ABSTRACT | PDF | Graphical Abstract | Press Release (Standard) | Press Release (Purple Elf) |
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Ali SR, Fong J, Carlin AF, Busch TD,
Linden R, Angata T, Areschoug T, Parast M, Varki N, Murray
J, Nizet V, Varki A. Siglec-5 and Siglec-14 are polymorphic
paired receptors that modulate neutrophil and amnion
signaling responses to group B Streptococcus. J
Exp Med 2014; 211:1231-1242. ABSTRACT
| PDF | Press
Release |
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Chang YC, Olson J, Louie A, Crocker PR,
Varki A, Nizet V. Role of macrophage sialoadhesin in
host defense against the sialylated pathogen group B Streptococcus.
J Mol Med 2014; 92:951-9. ABSTRACT
| PDF | Supplemental |
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Hensler ME, Jang KH, Thienphrapa W, Vuong
L, Tran DN, Soubih E, Lin L, Haste NM, Cunningham ML, Kwan
B, Shaw KJ, Fenical W, Nizet V. Anthracimycin activity
against contemporary methicillin-resistant Staphylococcus
aureus. J Antibiot 2014;
67:549-53. ABSTRACT
| PDF |
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Walker MJ, Barnett TC, McArthur JD, Cole
JN, Gillen CM, Henningham A, Sriprakash KS, Sanderson-Smith
ML, Nizet V. Disease manifestations and pathogenic
mechanisms of group A Streptococcus. Clin Micro
Rev 2014; 27:264-301. ABSTRACT
| PDF |
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Gonzalez DJ, Vuong L, Gonzalez IS, Keller
N, McGrosso D, Hwang HK, Hung J, Zinkernagel AS, Dixon JE,
Dorrestein PC, Nizet V. Phenol soluble modulin
variants of community-associated methicillin-resistant Staphylococcus
aureus captured using mass spectrometry-based
molecular networking. Mol Cell Proteomics 2014;
13:1262-1272. ABSTRACT
| PDF |
Supplemental |
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Tagliabracci VS, Engel JL, Wiley SE, Xiao
J, Gonzalez DJ, Nidumanda Appaiah H, Nizet V, White KE,
Dixon JE. Dynamic regulation of FGF23 by FAM20C
phosphorylation, GALNT3 glycosylation and Furin
proteolysis. Proc Natl Acad Sci USA 2014;
111:5520-5525. ABSTRACT
| PDF |
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Sakoulas G, Guram K, Reyes K, Nizet V,
Zervos M. Human cathelicidin LL-37 resistance and
increased daptomycin MIC in USA600 (ST45)
methicillin-resistant Staphylococcus aureus is
associated with increased mortality in a hospital
setting. J Clin Microbiol 2014;
52:2172-2174. ABSTRACT
| PDF | Supplemental
|
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Liu Y, Haste NM, Thienphrapa W, Li J,
Nizet V, Hensler M, Li R. Marinopyrrole derivatives as
potential antibiotic agents against methicillin-resistant Staphylococcus aureus
(III). Marine Drugs 2014; 12:2458-2470. ABSTRACT
| PDF
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Sakoulas G, Rose W, Nonjuie P, Olson J,
Pogliano J, Humphries R, Nizet V. Ceftaroline restores
daptomycin killing of daptomycin-nonsusceptible
vancomycin-resistant Enterococcus faecium. Antimicrob
Agents Chemother 2014; 58:1494-1500. ABSTRACT
| PDF |
Supplemental |
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Roupé KM, Veerla S, Olson J, Stone EL,
Sørensen O, Hedrick SM, Nizet V. Transcription factor
binding site analysis identifies FOXO transcription factors
as regulators of the cutaneous wound healing process.
PLoS One 2014; 9: e89274. ABSTRACT
| PDF | Supplemental |
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Randis TM, Gelber SE, Hooven TA, Abellar
RG, Akabas LH, Lewis EL, Walker LB, Byland LM, Nizet V,
Ratner AJ. Group B Streptococcus
β-hemolysin/cytolysin breaches maternal-fetal barriers to
cause preterm birth and intrauterine fetal demise in
vivo. J Infect Dis 2014; 210:265-73.
ABSTRACT
| PDF |
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Opaluch AM, Schneider M, Chiang CY, Nguyen
QT, Maestre AM, Mulder LC, Secundino I, De Jesus PD, König
R, Simon V, Nizet V, MacLeod G, Varmuza S, Fernandez-Sesma
A, Chanda SK. Positive regulation of TRAF6-dependent
innate immune responses by protein phosphatase PP1-γ.
PLoS One 2014 9: e89284 ABSTRACT
| PDF | Supplemental |
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Askarian F, van Sorge NM, Sangvika M,
Beasley FC, Henriksend JR, Sollida JU, van Strijp J, Nizet
V, Johannessen M. Α Staphylococcus aureus TIR-domain
protein virulence factor blocks TLR2-mediated NF-κB
signaling. J Innate Immun 2014;
6:485-98. ABSTRACT
|
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Franks SE, Ebrahimi C, Hollands A, Okumura
CY, Aroian RV, Nizet V, McGillivray SM. A novel role
for the yceGH tellurium resistance genes in the
pathogenesis of Bacillus anthracis. Infect
Immun 2014; 82:1132-1140. ABSTRACT
| PDF |
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Cowburn AS, Crotty Alexander LE, Nizet V,
Chilvers ER, Johnson RS. Epidermal deletion of HIF-2α
stimulates wound closure. J Invest Derm 2014;
134: 801–808. ABSTRACT
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Ly D, Taylor JM, Tsatsaronis JA, Monteleone MM, Skora AS, Donald CA, Maddocks T, Nizet V, West NP, Ranson M, Walker MJ, McArthur JD, Sanderson-Smith ML. Plasmin(ogen) acquisition by group A Streptococcus protects against C3b-mediated neutrophil killing. J Innate Immun 2014;6:240-50. ABSTRACT | PDF | Supplemental |
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Anderson EL, Cole JN, Olson J, Ryba B,
Ghosh P, Nizet V. The fibrinogen-binding M1 protein
reduces pharyngeal cell adherence and colonization
phenotypes of M1T1 group A Streptococcus. J
Biol Chem 2014; 289:3539–3546. ABSTRACT |
PDF |
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Padler-Karavani V, Hurtado-Ziola N, Chang YC, Sonnenburg JL, Ronaghy A, Yu H, Verhagen A, Nizet V, Chen X, Varki N, Varki A, Angata T. Rapid evolution of binding specificities and expression patterns of inhibitory CD33-related Siglecs in primates. FASEB J 2014; 28:1280-1293. ABSTRACT | PDF |
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Yamanaka K, Reynolds KA, Kersten RD, Ryan
KS, Gonzalez DJ, Nizet V, Dorrestein PC, Moore BS.
Direct cloning and refactoring of a silent lipopeptide
biosynthetic gene cluster yields the antibiotic taromycin A. |
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Chang YC, Olson J, Beasley FC, Tung C,
Zhang J, Crocker PR, Varki A, Nizet V. Group B Streptococcus
engages an inhibitory Siglec through sialic acid mimicry to
blunt innate immune and inflammatory responses in vivo.
PLoS Pathogens 2014; 10: e1003846. ABSTRACT
|
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Sakoulas G, Okumura CY, Thienphrapa
W, Olson J, Nonejuie P, Dam Q, Dhand A, Pogliano J, Yeaman
MR, Hensler ME, Bayer AS, Nizet V. Nafcillin
enhances innate immune-mediated killing of
methicillin-resistant Staphylococcus aureus.
J Mol Med 2014; 92:139-149. ABSTRACT
|
PDF | Commentary |
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Lin AE, Autran CA, Española SD, Bode L, Nizet V. Human milk oligosaccharides protect bladder epithelial cells against uropathogenic Escherichia coli invasion and cytotoxicity. J Infect Dis 2014; 209:389-398. ABSTRACT | PDF | Supplemental | Nat Rev Urology |
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Crotty Alexander L, Marsh B, Timmer A, Lin
AE, Zainabadi K, Czopik A, Guarente L, Nizet V.
Myeloid cell SIRT1 expression does not alter host
immune responses to Gram-negative endotoxemia or
Gram-positive bacterial infection. PLoS One
2013; 8: e84481. ABSTRACT
|
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Barnett TC, Liebl D, Seymour LM, Gillen
CM, Lim JY, LaRock CN, Davies MR, Shulz BL, Nizet V,
Teasdale RD, Walker MJ. The group A Streptococcus
M1T1 clone evades autophagy for intracellular
replication. Cell Host Microbe 2013;
14:675-682 (cover article) ABSTRACT
|
PDF | Supplemental
| Commentary
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Grewal PK, Aziz PV, Uchiyama S, Rubio GR,
Le D, Varki N, Nizet V, Marth JD. Inducing host protection
in pneumococcal sepsis by pre-activation of the
Ashwell-Morell receptor. Proc Natl Acad Sci USA
2013; 110:20218-23 ABSTRACT
|
PDF | Supplemental
|
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Fine AM, Nizet V, Mandl KD.
Participatory medicine: a home score for streptococcal
pharyngitis enabled by real-time biosurveillance: a cohort
study. Ann Intern Med 2013; 159:577-583.
ABSTRACT
|
PDF | Commentary 1
| Commentary 2
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Kersten RD, Ziemert N, Gonzalez DJ, Duggan
BM, Nizet V, Dorrestein PC, Moore BS. Glycogenomics as a
mass spectrometry guided genome mining method for microbial
glycosylated molecules. Proc Natl Acad Sci USA
2013; 110:E4407-16. ABSTRACT
|
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Yamaguchi M, Terao Y, Mori-Yamaguchi Y,
Domon H, Sakaue Y, Yagi T, Nishino K, Yamaguchi A, Nizet V,
Kawabata S. Streptococcus pneumoniae invades
erythrocytes and utilizes them to evade human innate
immunity. PLoS
One 2013; 8:e77282. ABSTRACT
|
PDF |
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Cowburn AS, Takeda N, Boutin AT, Kim J-W,
Sterling JC, Nakasaki M, Southwood M, Goldrath AW, Jamora C,
Nizet V, Chilvers ER, Johnson RS. HIF isoforms in the
skin differentially regulate systemic arterial
pressure. Proc Natl Acad Sci USA 2013;
110:17570-17575. ABSTRACT
|
PDF | Supplemental
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Guichard A, Cruz-Moreno B, Aguilar B, van
Sorge NM, Kuang J, Kurkciyan AA, Wang Z, Hang S, Pineton de
Chambrun GP, McCole DF, Watnick P, Nizet V, Bier E. Cholera
toxin disrupts exocyst-mediated protein trafficking to
intestinal epithelial cell junctions. Cell Host Microbe
2013;14:294-305. ABSTRACT
|
PDF | Supplemental
| Commentary
| Graphical
Abstract | Press
Release |
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Nizet V, Doran K. Group B
Streptococcal Meningitis. In: "Meningitis: Cellular and
Molecular Basis" (M. Christodoulides, ed.), CABI, London,
2013, pp. 118-132. PDF |
|
Nizet V, Yaksh T. Neuroscience:
Bacteria get on your nerves. Nature 2013;
501:43-44. PDF
| SciBx |
 |
Leire E, Olson J, Isaacs H, Nizet V,
Hollands A. Role of hypoxia inducible factor-1 in
keratinocyte inflammatory response and neutrophil
recruitment. J Inflamm 2013; 10:28 ABSTRACT
|
PDF |
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Okumura CY, Anderson EL, Döhrmann S, Tran
DN, Olson J, von Pawel-Rammingen U, Nizet V. IgG
protease Mac/IdeS is not essential for phagocyte resistance
or mouse virulence of M1T1 group A Streptococcus.
mBio 2013;
4:3e0049-13. ABSTRACT
|
PDF |
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Berti AE, Sakoulas G, Nizet V, Tewhey R,
Rose WE. β-lactam antibiotics targeting PBP1
selectively enhance daptomycin activity against
methicillin-resistant Staphylococcus aureus. Antimicrob
Agents Chemother 2013; 57:5005-5012. ABSTRACT
|
PDF |
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Sjögren J, Struwe W, Cosgrave E, Rudd P,
Stervander M, Allhorn M, Hollands A, Nizet V, Collin M.
EndoS2 is a unique and conserved protein of serotype M49
group A Streptococcus that hydrolyzes N-linked
glycans on IgG and α1-acid glycoprotein. Biochem J
2013; 455:107-118. ABSTRACT
|
PDF | Supplemental |
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Sanderson-Smith ML, Zhang Y, Ly D, Donahue
D, Hollands A, Nizet V, Ploplis VA, Walker MJ, Castellino
FJ. A key role for the urokinase plasminogen activator
(uPA) in invasive group A streptococcal infection. PLoS Pathogens
2013; 9:e1003469 ABSTRACT
|
PDF | Supplemental |
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Corriden R, Self T, Akong-Moore K, Nizet
V, Kellam B, Briddon S, Hill S. Human neutrophil
A3-adenosine receptor microdomains promote
bacteria-tethering cytoneme formation. EMBO
Reports 2013; 14:726-732. ABSTRACT
|
PDF | Supplemental
| Video
S1 | Video
S2 | Video
S3 |
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Bhandari T, Olson J, Johnson RS, Nizet
V. HIF-1α influences myeloid cell antigen presentation
and response to subcutaneous OVA vaccination. J
Mol Med 2013; 91:1199-1205. ABSTRACT
|
PDF |
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Sakoulas G, Nonejuie P, Nizet V, Pogliano
J, Crum-Ciaflone N, Haddad F. Treatment of recurrent
high-level gentamicin-resistant Enterococcus faecalis
endocarditis with daptomycin plus ceftaroline. Antimicrob
Agents
Chemother 2013; 57: 4042-4045. ABSTRACT
|
PDF |
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Jantsch J, Gerlach R, Ensser A, Dahesh S,
Popp I, Heeg C, Bleiziffer O, Merz T, Schulz T, Horch R,
Bogdan C, Nizet V, Van Der Linden M. Severe soft
tissue infection caused by a non-β-hemolytic Streptococcus
pyogenes strain harboring a premature stop mutation in
the sagC gene. J Clin Microbiol 2013;
51:1962–1965. ABSTRACT |
PDF |
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Venturini C, Ong CY, Gillen CM, Ben-Zakour N, Maamary PG, Nizet V, Beatson SA, Walker MJ. Enhanced virulence through Acquisition of Sda1-encoding bacteriophage does not enhance virulence of the M1 Streptococcus pyogenes strain SF370. Infect Immun 2013; 81:2062-2069. ABSTRACT | PDF |
|
Tsatsaronis J, Hollands A, Cole JN,
Maamary PG, McArthur JD, Ben Zakour N, Kotb M, Nizet V,
Beatson S, Walker MJ, Sanderson-Smith ML.
Streptococcal collagen-like protein A and general stress
protein 24 are immuno-modulating virulence factors of group
A Streptococcus. FASEB J 2013;
27:2633-43. ABSTRACT
|
PDF | Supplemental |
|
Tannahill GM, Curtis AM, Adamik J, Palsson-McDermott EM, McGettrick AF, Goel G, Frezza C, Bernard NJ, Kelly B, Foley NH, Zheng L, Gardet A, Tong Z, Jany SS, Corr SC, Clish C, Haneklaus M, Caffrey BE, Pierce K, Walmsley S, Beasley FC, Cummins E, Nizet V, Whyte M, Taylor CT, Lin H, Masters SL, Gottlieb E, Kelly VP, Clish C, Auron PE, Xavier RJ, O’Neill LAJ. Succinate is an inflammatory signal that induces IL-1β transcription through HIF-1α. Nature 2013; 496:238-242. ABSTRACT | PDF | Supplemental |
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Angata T, Ishii T, Motegi T, Oka R, Taylor RE, Campos-Soto P, Chang YC, Secundino I, Gao CX, Ohtsubo K, Kitazume S, Nizet V, Varki A, Gemma A, Kida K, Taniguchi N. Loss of Siglec-14 reduces the risk of chronic obstructive pulmonary disease exacerbation. Cell Mol Life Sci 2013; 70:3199-3210. ABSTRACT | PDF |
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Uchiyama S, Andreoni F, Zürcher C, Schilcher K, Ender M, Madon J, Matt U, Ghosh P, Nizet V, Scheupbach RA, Zinkernagel AS. Coiled-coil irregularities of the M1 protein structure promote M1-fibrinogen interaction and influence group A Streptococcus host cell interactions and virulence. J Mol Med 2013; 91:861-869. ABSTRACT | PDF | Supplemental |
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Baek KJ, Cho JY, Rosenthal P, Crotty
Alexander LE, Nizet V, Broide DH. Hypoxia potentiates
allergen induction of HIF-1α, chemokines, airway
inflammation, TGF-β1, and airway remodeling in a mouse
model. Clin Immunol 2013; 147:27-37. ABSTRACT
|
PDF |
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van Sorge NM, Beasley FC, Gusarov I, Gonzalez DJ, von Köckritz-Blickwede M, Anik S, Borkowski A, Dorrestein PC, Nudler E, Nizet V. Methicillin-resistant Staphylococcus aureus bacterial nitric oxide synthase affects antibiotic sensitivity and skin abscess development. J Biol Chem 2013; 288:6417-6426. ABSTRACT | PDF | Supplemental |
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Zhu W, Zhang Y, Sinko W, Hensler ME, Olson J, Molohon KJ, Lindert S, Cao R, Li K, Wang K, Wang Y, Liu YL, Sankovsky A, de Oliveira CA, Mitchell DA, Nizet V, McCammon JA, Oldfield E. Antibacterial drug leads targeting isoprenoid biosynthesis. Proc Natl Acad Sci 2013; 110:123-125. ABSTRACT | PDF |
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Crotty Alexander LE, Akong-Moore K, Feldstein S, Johansson P, Nguyen A, McEachern EK, Nicatia S, Cowburn AS, Olson J, Cho JY, Isaacs H, Johnson RS, Broide DH, Nizet V. Myeloid cell HIF-1α regulates asthma airway resistance and eosinophil function. J Mol Med 2013; 91:637-44 ABSTRACT | PDF |
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Hollands A,
Gonzalez DJ, Leire E, Donald C, Gallo RL, Sanderson-Smith M,
Dorrestein PC, Nizet V. A bacterial pathogens co-opts
host plasmin to resist killing by cathelicidin antimicrobial
peptides. J Biol Chem 2012; 287: 40891-40897.
ABSTRACT
| PDF |
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Kuang E, Okumura CY, Sheffy-Levin S, Varzano T, Shu VC, Qi
J, Niesman IR, Olson J, Reed JC, Broday L, Nizet V, Ronai
ZA. Regulation of ATG4B stability by RNF5 limits basal
levels of autophagy and influences susceptibility to
bacterial infection. PLoS Genetics
2012; 8(10):e1003007. ABSTRACT
|
PDF |
| |
Haste NM,
Thienphrapa W, Tran DN, Loesgen S, Sun P, Nam SJ, Jensen PR,
Fenical W, Sakoulas G, Nizet V, Hensler ME. Activity of the
thiopeptide antibiotic nosiheptide against contemporary
strains of methicillin-resistant Staphylococcus aureus.
J Antibiotics 2012; 65: 593-598. ABSTRACT
|
PDF |
| |
Rose WE, Eickhoff JC, Shukla SK, Pantarangi M, Rooijakkers
SH, Cosgrove SE, Nizet V, Sakoulas G. Elevated serum
interleukin-10 (IL-10) at time of hospital admission is
predictive of mortality in patients with Staphylococcus
aureus bacteremia. J Infect Dis 2012;
206:1604-1611. ABSTRACT
|
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| |
Humphries
RM,
Kelesidis T, Tewhey R, Rose W, Schork N, Nizet V, Sakoulas
G. Genotypic and phenotypic evaluation of the
evolution of high-level daptomycin non-susceptibility in
vancomycin-resistant Enterococcus faecium. Antimicrob
Agents Chemother 2012; 56:6051-3. ABSTRACT
|
PDF |
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Cole JN, Aziz
RK, Kuipers K, Timmer AM, Nizet V, van Sorge NM. A
conserved UDP-glucose dehydrogenase outside the hasABC
operon contributes to capsule biogenesis in group A
Streptococcus. J Bacteriol 2012; 194:6154-61.
ABSTRACT
|
PDF |
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Dahesh S, Nizet V, Cole JN. Study of streptococcal hemoprotein receptor (Shr) in iron acquisition and virulence of M1T1 group A Streptococcus. Virulence 2012; 3:566-575. ABSTRACT | PDF | Commentary |
|
Arnold JC, Nizet V. Pharyngitis. In: Principles and Practices of Pediatric Infectious Diseases, 4th Edition (S Long, LK Pickering, CG Prober, eds.). Elsevier, Philadelphia, Chapter 27, pp. 199-205. 2012. PDF |
|
Nizet V, Arnold JC. Streptococcus pyogenes (Group A Streptococcus).
In:
Principles and Practices of Pediatric Infectious Diseases,
4th Edition (S Long, LK Pickering, CG Prober, eds.).
Elsevier, Philadelphia, Chapter 118, pp. 698-707.
2012. |
|
|
Maamary PG, Ben
Zakour NL, Cole JN, Hollands A, Barnett TC, Cork AJ,
Henningham A, Sanderson-Smith M, McArthur JD, Venturini C,
Gillen CM, Kirk JK, Johnson DR, Aziz RK, Taylor WL, Kaplan
EL, Kotb M, Nizet V, Beatson SA, Walker MJ. Evolution
and selection for the pandemic group A streptococcal M1T1
clone. FASEB J 2012; 26:4675-84. ABSTRACT
|
PDF |
|
|
Akong-Moore K,
Chow OA, von Köckritz-Blickwede M, Nizet V.
Influences of chloride and hypochlorite on neutrophil
extracellular extracellular trap formation. PLoS
One 2012 7:e42984. ABSTRACT
|
PDF |
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Branitzki-Heinemann K, Okumura CY, Völlger
L, Kawakami Y, Kawakami T, Naim HY, Nizet V, von
Köckritz-Blickwede M. Novel role of the transcription
factor HIF-1α in
the formation of mast cell extracellular traps. Biochem J 2012;
446:159-163. ABSTRACT
|
PDF |
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Bebien M, Hensler ME, Hsu LC, Karin M,
Park JM, Alexopoulou L, Liu GY, Nizet V, Lawrence T.
The pore-forming toxin ß-hemolysin/cytolysin triggers p38
MAPK-dependent IL-10 production in macrophages and inhibits
innate immunity. PLoS Pathogens 2012; 8:e1002812 ABSTRACT
|
PDF |
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Gonzalez DJ, Xu Y, Yang YL, Esquenazi E,
Liu WT, Edlund A, Duong T, Du L, Molnár I, Gerwick WH,
Jensen PR, Fischbach M, Liaw CC, Straight P, Nizet V,
Dorrestein PC. Observing the invisible through imaging
mass spectrometry, a window into the metabolic exchange
patterns of microbes. J Proteomics 2012;
75:5069-5076. ABSTRACT
|
PDF | Supplemental |
|
Uchiyama S, Andreoni F, Schüpbach RA,
Nizet V, Zinkernagel AS. DNase Sda1 allows invasive
M1T1 group A Streptococcus
to prevent TLR9 recognition. PLoS Pathogens
2012; 8:e1002736
ABSTRACT
|
PDF | Supplemental |
|
Wang X, Mitra N, Secundino-Velasquez I,
Banda K, Cruz P, Padler-Karavani V, Verhagen A, Reid C, Lari
M, Rizzi E, Balsamo C, Corti G, De Bellis G, Longo L, NISC
Comparative Sequencing Program, Beggs W, Caramelli D,
Tishkoff S, Hayakawa T, Green ED, Mulliken JC, Nizet V, Bui
JD, Varki A. Specific inactivation of two
immunomodulatory SIGLEC
genes during human evolution. Proc Natl Acad Sci USA
2012; 109:9935-9940.
ABSTRACT
| PDF |
Supplemental
| Press
Release |
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Fair RJ, Hensler ME, Thienphrapa W, Dam
QN, Nizet V, Tor Y. Selectively guanidinylated
aminoglycosides as antibiotics. ChemMedChem
2012; 7:1237-1244.
ABSTRACT
|
PDF | Supplemental |
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van der Westhuyzen R, Hammons J, Meier J,
Dahesh S, Moolman W, Pelley S, Nizet V, Burkart M, Strauss
E. The antibiotic CJ-15,801 is an antimetabolite which
hijacks and then inhibits CoA biosynthesis. Chem Biol 2012;
19:559-571 (Cover article). ABSTRACT
|
PDF | Commentary |
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Fine AM, Nizet V, Mandl KD. Large-scale validation of the Centor and McIsaac scores to predict group A streptococcal pharyngitis. Arch Intern Med 2012; 172:847-852. ABSTRACT | PDF + Commentary |
|
Sano R, Hou YC, Hedvat M, Correa RG, Shu
CW, Krajewska M, Diaz PW, Quarato G, Gottlieb RA, Yamaguchi
M, Nizet V, Dahl R, Thomas DD, Tait SW, Green DR,
Fisher PB, Matsuzawa SI, Reed JC. Endoplasmic
Reticulum Protein BI-1 regulates Ca2+-mediated bioenergetics
to promote autophagy. Genes Dev 2012; 26:1041-54. ABSTRACT
|
PDF | Supplemental |
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Gonzalez DJ, Okumura CY, Hollands A,
Kersten R, Akong-Moore K, Pence MA, Malone CL, Derieux J,
Moore BS, Horswill, AR, Dixon JE, Dorrestein PC, Nizet V.
Novel phenol soluble modulin derivatives in
community-associated methicillin-resistant Staphylococcus aureus
identified through imaging mass spectrometry. J Biol Chem
2012; 287:13889-13898. ABSTRACT
|
PDF | Supplemental
|
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Liu Y, Haste NM, Thienphrapa W, Nizet V, Hensler ME, Li R. Marinopyrrole derivatives as potential antibiotic agents against methicillin-resistant Staphylococcus aureus. Marine Drugs 2012; 10:953-962. ABSTRACT | PDF |
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Henningham A, Chiarot E, Gillen CM, Cole
JN, Rohde M, Fulde M, Ramachandran V, Cork AJ, Hartas J,
Magor G, Djordjevic SP, Cordwell SJ, Kobe B,
Sriprakash KS, Nizet V, Chhatwal GS, Batzloff MR, Margarit
IR, Walker MJ. Conserved anchorless surface proteins
as group A streptococcal vaccine candidates. J Mol Med 2012;
90:1197-1207.
ABSTRACT
|
PDF | Supplemental |
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Zhang Y, Lin FY, Li K, Zhu W, Liu YL, Cao
R, Pang R, Lee E, Axelson J, Hensler ME, Wang K, Molohon K,
Mitchell D, Nizet V, Oldfield E. HIV integrase
inhibitor-inspired antibacterials targeting isoprenoid
biosynthesis. ACS Med Chem Lett 2012; 3:402-406. ABSTRACT
|
PDF | Supplemental |
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Hertzén E, Johansson L, Kansal R, Hecht A, Dahesh S, Marton J, Nizet V, Kotb M, Norrby-Teglund A. Intracellular Streptococcus pyogenes in human macrophages display an altered gene expression profile. PLoS One 2012; 7:e35218. ABSTRACT | PDF |
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McGillivray SM, Tran DN, Ramadoss NS, Alumasa JN, Okumura CY, Sakoulas G, Vaughn MM, Zhang DX, Keiler KC, Nizet V. Pharmacological inhibition of the ClpXP protease increases bacterial susceptibility to host cathelicidin antimicrobial peptides and cell-envelope active antibiotics. Antimicrob Agents Chemother 2012; 56:1854-1861. ABSTRACT | PDF |
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Chiang CY, Engel A, Opaluch AM, Ramos I,
Maestre AM, Secundino I, De Jesus PD, Nguyen QT, Welch G,
Bonamy GM, Miraglia LJ, Orth AP, Nizet V, Fernandez-Sesma A,
Zhou Y, Barton GM, Chanda SK. Co-factors required for
TLR7 and TLR9- dependent innate immune responses. Cell Host Microbe
2012; 11:306-318. ABSTRACT
|
PDF | Supplemental
| Graphic |
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Okumura CYM, Hollands A, Tran DN, Olson J,
Dahesh S, von Köckritz-Blickwede M, Thienphrapa W, Corle C,
Jeung SN, Kotsakis A, Shalwitz RA, Johnson RS, Nizet V. A
new pharmacological agent (AKB-4924) stabilizes hypoxia
inducible factor (HIF) and increases skin innate defenses
against bacterial infection. J Mol Med 2012;
90:1079-1089.
ABSTRACT
|
PDF |
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Jongerius I, von Köckritz-Blickwede M,
Horsburgh MJ, Ruyken M, Nizet V, Rooijakkers SH. Staphylococcus aureus
virulence is enhanced by secreted factors that block innate
immune defenses. J Innate Immun 2012; 4:301-311. ABSTRACT
|
PDF | Supplemental |
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Lin FY, Zhang Y, Hensler ME, Liu YL, Chow
OA, Zhu W, Wang K, Pan R, Thienphrapa W, Nizet V, Oldfield
E. Dual dehydrosqualene synthase/squalene synthase
inhibitors: Leads for innate immune system based
therapeutics. ChemMedChem 2012; 7:561-564. ABSTRACT
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Sakoulas G, Bayer AS, Pogliano J, Tsuji BT, Yang SJ, Mishra NN, Nizet V, Yeaman MR, Moise PA. Ampicillin enhances daptomycin- and cationic host defense peptide-mediated killing of ampicillin- and vancomycin-resistant Enterococcus faecium. Antimicrob Agents Chemother 2012; 56:838-844. ABSTRACT | PDF |
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Sakoulas G, Nam S-J, Loesgen S, Fenical W, Jensen PR, Nizet V, Hensler M. Novel bacterial metabolite merochlorin A demonstrates activity against multi-drug resistant methicillin-resistant Staphylococcus aureus. PLoS One 2012; 7:e29439. ABSTRACT | PDF |
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Chang YC, Uchiyama S, Varki A, Nizet V. Leukocyte inflammatory responses provoked by pneumococcal sialidase. mBio 2012; 3:e00220-11. ABSTRACT | PDF |
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Guichard A, Nizet V, Bier E. New insights into the biological effects of anthrax toxins: linking cellular to organismal responses. Microb Infect 2012; 14:97-118. ABSTRACT | PDF |
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Carland TM,
Locke JB, Nizet V, Gerwick L. Differential expression
and intrachromosomal evolution of the sghC1q genes in
zebrafish (Danio rerio).
Dev Comp Immunol
2012; 36:31-38. ABSTRACT
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PDF |
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Zinkernagel AS, Hruz P, Uchiyama S, von
Köckritz-Blickwede M, Schuepbach RA, Hayashi T, Carson DA,
Nizet V. Importance of Toll-like receptor 9 in host
defense against M1T1 group A Streptococcus infections. J Innate Immun
2012; 4:213-218. ABSTRACT
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Kho MF,
Bellier A, Balasubramini V, Hu Y, Hsu W, Nielsen-LeRoux C,
McGillivray SM, Nizet V, Aroian RV. The pore-forming protein
Cry5B elicits the pathogenicity of Bacillus sp. against Caenorhabditis elegans.
PLoS One
2011; 6: e29122. ABSTRACT
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PDF |
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Nordström T,
Movert E, Olin A, Ali SR, Nizet V, Varki A, Areschoug
T. Human Siglec-5 inhibitory receptor and
immunoglobulin A (IgA) have separate binding sites in
streptococcal β protein. J Biol Chem 2011; 286:33981-33991. ABSTRACT
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Fine AM, Nizet V, Mandl KD. Improved diagnostic accuracy of group A streptococcal pharyngitis with use of real-time biosurveillance. Ann Intern_Med 2011; 155:345-352. ABSTRACT | PDF | Press Release |
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Cole JN,
Barnett TC, Nizet V, Walker MJ. Molecular insight into group
A streptococcal invasive disease. Nat Rev Microbiol
2011; 9:724-736. ABSTRACT
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PDF |
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Kinjo Y,
Illarionov P, Vela JL, Pei B, Girardi E, Li X, Li Y, Imamura
M, Kaneko Y, Okawara A, Miyazaki Y, Gómez-Velasco A, Rogers
P, Dahesh S, Uchiyama S, Khurana A, Kawahara K, Yesilkaya H,
Andrew PW, Wong CH, Kawakami K, Nizet V, Besra GS, Tsuji M,
Zajonc DM, Kronenberg M. Invariant NKT cells recognize
glycolipids from pathogenic Gram-positive bacteria. Nat Immunol
2011; 12:966-974. ABSTRACT
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PDF | Supplemental |
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Sun P,
Maloney KN, Nam SJ, Haste NM, Raju R, Aalsbersberg W, Jensen
PR, Nizet V, Hensler ME, Fenical W. Fijimycins A-C,
three antibacterial etamycin-class depsipeptides from a
marine-derived Streptomyces
sp. Bioorg
Med Chem 2011; 19:6557-6662. ABSTRACT
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PDF |
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Gonzalez DJ, Haste NM, Hollands A, Fleming T, Hambya M, Pogliano K, Nizet V, Dorrestein PC. Microbial competition between Bacillus subtilis and Staphylococcus aureus monitored by imaging mass spectrometry. Microbiology 2011; 57:2485–2492. ABSTRACT | PDF | Supplemental |
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Sjögren J, Okumura CY, Collin M, Nizet V, Hollands A. Study of the IgG endoglycosidase EndoS in group A streptococcal phagocyte resistance and virulence. BMC Microbiol 2011; 11:120. ABSTRACT | PDF |
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Chang YC,
Wang Z, Flax LA, Xu D, Esko JD Nizet V, Baron MJ.
Glycosaminoglycan binding facilitates entry of a bacterial
pathogen into central nervous systems. PLoS Pathogens
2011; 7:e1002082
ABSTRACT
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Dhand A,
Bayer AS, Pogliano J, Yang SJ, Bolaris M, Nizet V, Wang G,
Sakoulas G. Use of antistaphylococcal β-lactams to
increase daptomycin activity in eradicating persistent
bacteremia due to methicillin-resistant Staphylococcus aureus:
role of enhanced daptomycin binding. Clin Infect Dis
2011; 53: 158-163. ABSTRACT
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PDF |
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Ali SR,
Timmer AM, Bilgrami S, Park EJ, Eckmann L, Nizet V, Karin M.
Anthrax toxin induces macrophage death by p38 MAPK
inhibition but leads to inflammasome activation via ATP
leakage. Immunity
2011; 35:34-44. ABSTRACT
| PDF | Supplemental
| Press
Release |
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Haste NM, Hughes CC, Tran DN, Fenical W, Jensen PR, Nizet V, Hensler ME. Pharmacological properties of the marine natural product marinopyrrole A against methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 2011; 55:3305-3312. ABSTRACT | PDF |
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Amelung S,
Nerlick A, Rohde M, Spellerberg B, Cole JN, Nizet V,
Chhatwal GS, Talay SR. The FbaB-type fibronectin-binding
protein of Streptococcus
pyogenes promotes specific invasion into
endothelial cells. Cell Microbiol 2011; 13:1200-1211. ABSTRACT
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Haste NM, Farnaes L, Perera VR, Fenical W, Nizet V, Hensler ME. Bactericidal kinetics of marine-derived napyradiomycins against contemporary methicillin-resistant Staphylococcus aureus. Marine Drugs 2011; 9:680-689. ABSTRACT | PDF |
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Kisseleva T,
von Köckritz-Blickwede M, Reichart D, McGillvray SM,
Wingender G, Kronenberg M, Glass CK, Nizet V, Brenner DA.
Fibrocyte-like cells recruited to the spleen support innate
and adaptive immune responses to acute injury or
infection. J
Mol Med 2011; 89:997-1013. ABSTRACT
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Macheboeuf P, Buffalo C, Fu CY, Zinkernagel AS, Cole JN, Johnson JE, Nizet V, Ghosh P. Streptococcal M1 protein constructs a pathological host fibrinogen network. Nature 2011; 472:64-68. ABSTRACT | PDF | Supplemental | Movie | Press Release |
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Yang H,
Sikavi C, Tran K, McGillivray SM, Nizet V, Yung M, Chang A,
Miller JH. Papillation in Bacillus anthracis colonies: a tool for
finding new mutators. Mol Microbiol 2011;
79:1276-1293. ABSTRACT
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Reiß A, Braun JS, Jäger K, Freyer D, Laube G, Bührer C, Felderhoff-Müser U, Nizet V, Weber JR. Bacterial pore-forming cytolysins induce neuronal damage in a rat model of neonatal meningitis. J Infect Dis 2011; 3:393-400. ABSTRACT | PDF |
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Hsu LC,
Enzler T, Seita J, Timmer AM, Lee CY, Lai TY, Yu GY, Lai LC,
Temkin V, Nizet V, Weissman IL, Karin M. IL-1β-driven
neutrophilia preserves antibacterial defense in the absence
of the kinase IKKβ. Nat Immunol
2011; 12:144-50. ABSTRACT
|
PDF | Supplemental |
Press
Release | Russian
Podcast |
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Nizet V, Bradley JS. Staphylococcal infections. In: Infectious Diseases of the Fetus and Newborn Infant, 7th Edition. (J Remington, JO Klein, CB Wilson, V. Nizet, B. Maldonado, eds.) Elsevier, Philadelphia, p. 489-515, 2011. PDF |
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Edwards MS, Nizet V, Baker CJ. Group B streptococcal infections. In: Infectious Diseases of the Fetus and Newborn Infant, 7th Edition (J Remington, JO Klein, CB Wilson, V. Nizet, B. Maldonado, eds.) Elsevier, Philadelphia, p. 419-469, 2011. PDF |
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Nizet V, Klein JO. Bacterial sepsis and meningitis. In: Infectious Diseases of the Fetus and Newborn Infant, 7th Edition. (J Remington, JO Klein, CB Wilson, V. Nizet, B. Maldonado, eds.) Elsevier, Philadelphia, p. 222-275, 2011. PDF |
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Nicolaou KC,
Simmons NL, Chen JS, Haste NM, Nizet V. Total
synthesis and biological evaluation of marinopyrrole A and
analogs. Tetrahed
Lett 2011; 52:2041-2043. ABSTRACT
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Chow OA, von
Köckritz-Blickwede M, Bright AT, Hensler ME, Zinkernagel AS,
Cogen AL, Gallo RL, Monestier M, Wang Y, Glass CK, Nizet
V. Statins enhance formation of phagocyte
extracellular traps. Cell Host Microbe 2010; 8:445-454.
ABSTRACT
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| Press
Release |
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Guichard A,
McGillivray SM, Moreno BC, van Sorge NM, Nizet V, Bier
E. Anthrax toxins cooperatively inhibit endocytic
recycling by the Rab11/Sec15 exocyst. Nature 2010;
467:854-858. ABSTRACT
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PDF | Supplemental
| Press
Release | Analizy
i
Komentarze |
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von
Köckritz-Blickwede M, Chow O, Ghochani M, Nizet V.
Visualization and functional evaluation of phagocyte
extracellular traps. In: Methods in Microbiology (Volume 37)
Immunology of Infection, 3rd Edition (D Kabelitz and SH
Kaufmann, eds). Academic Press, London, p. 139-160,
2010. PDF |
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Nizet
V. Bacteria and phagocytes: Mortal enemies. J Innate Immun
2010;
2:505-507. PDF |
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Berends ET, Horswill AR, Haste NM, Nizet V, von Köckritz-Blickwede M. Nuclease expression by Staphylococcus aureus facilitates escape from neutrophil extracellular traps. J Innate Immun 2010; 2:576-586. ABSTRACT | PDF | Supplemental |
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Cole JN,
Pence MA, von Köckritz-Blickwede M, Hollands A, Gallo RL,
Walker MJ, Nizet V. M protein and hyaluronic acid
capsule are essential for in
vivo selection of covR/S mutations characteristic of
invasive M1T1 group A Streptococcus. MBio 2010; 1:
e00191-10. ABSTRACT
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PDF |
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Maamary P, Sanderson-Smith M, Aziz R, Hollands A, McKay F, Cole J, McArthur J, Kirk J, Cork A, Keefe R, Kansal R, Sun H, Taylor W, Chhatwal C, Ginsburg D, Nizet V, Kotb M, Walker MJ. Parameters governing invasive disease propensity of non-M1 serotype group A streptococci. J Innate Immun 2010; 2:596-606 ABSTRACT | PDF | Supplemental |
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Pence MA,
Rooijakkers SH, Cogen AL, Cole JN, Hollands A, Gallo RL,
Nizet V. Streptococcal inhibitor of complement (SIC)
promotes innate immune resistance phenotypes of invasive
M1T1 group A Streptococcus.
J Innate Immun
2010; 2:587-595. ABSTRACT
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PDF | Supplemental |
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Liu WT, Yang
YL, Xu Y, Lamsa A, Haste NM, Yang JY, Ng J, Gonzalez DJ,
Ellermeier CD, Straight PD, Pevzner P, Pogliano J, Nizet V,
Pogliano K, Dorrestein PC. Imaging mass spectrometry
of intraspecies metabolic exchange revealed the
cannibalistic factors of Bacillus
subtilis. Proc Natl Acad Sci USA 2010; 107:16286-16290. ABSTRACT
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PDF | Supplemental
| Movie |
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Derbal S,
Hensler M, Fang W, Nizet V, Ghedira K, Nefzi A. On
resin amino acid side chain attachment strategy for the head
to tail synthesis of new glutamine containing gramicidin-S
analogs and their antimicrobial activity. Bioorg Med Chem Lett
2010; 20:5701-5704. ABSTRACT
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Zhao HW, Zhou
D, Nizet V, Haddad GG. Experimental selection for Drosophila survival in
extremely high O2 environments. PLoS One 2010; 5:e11701.
ABSTRACT | PDF |
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Taylor RE,
Gregg C, Padler-Karavani V, Ghaderi D, Yu H, Sorensen RU,
Chen X, Inostroza J, Nizet V, Varki A. Novel
mechanism for the generation of human xeno-auto-antibodies
against the non-human sialic acid N-glycolylneuraminic acid. J Exp Med 2010;
207:1637-1646. ABSTRACT
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Rooijakkers
SM, Rasmussen SL, McGillivray SM, Bartnikas TB, Mason AB,
Friedlander AM, Nizet V. Human transferrin confers
serum resistance against Bacillus
anthracis. J Biol Chem 2010;
285:27609-27613. ABSTRACT
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PDF |
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Hollands A,
Pence MA, Timmer AM, Osvath SR, Turnbull L, Whitchurch CB,
Walker MJ, Nizet V. Genetic switch to hypervirulence
reduces colonization phenotypes of the globally disseminated
group A Streptococcus
M1T1 clone. J
Infect Dis 2010; 202:11-19. ABSTRACT
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PDF |
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Gonzalez DJ,
Lee SW, Hensler ME, Dahesh S, Markley AL, Mitchell DA,
Bandeira N, Nizet V, Dixon JE, Dorrestein PC.
Clostridiolysin S: A post-translationally modified biotoxin
from Clostridium
botulinum. J Biol Chem 2010;
285:27798-27805. ABSTRACT
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Kaur SJ,
Nerlich A, Rohde M, Fulde MA, Zähner D, Hanski E,
Zinkernagel A, Nizet V, Chhatwal GS, Talay SR. The CXC
chemokine-degrading protease SpyCep of Streptococcus pyogenes
promotes its uptake into endothelial cells. J Biol Chem
2010; 285: 27798-27805. ABSTRACT
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Haste NM,
Perera V, Maloney KN, Tran DN, Jensen PR, Fenical W, Nizet V
and Hensler ME. Activity of the streptogramin
antibiotic etamycin against methicillin-resistant Staphylococcus aureus.
J Antibiotics
2010; 63:219-224.
ABSTRACT
| PDF | Supplemental |
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Weiman S, Uchiyama S, Lin FY, Chaffin D, Varki A, Nizet V, Lewis AL. O-Acetylation of sialic acid on group B Streptococcus inhibits neutrophil suppression and virulence. Biochem J 2010; 428:163-168. ABSTRACT | PDF |
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Aziz RK,
Nizet V. Pathogen microevolution in high resolution. Sci Transl Med
2010; 2:16ps4
ABSTRACT
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Stockmann C,
Kerdiles Y, Nomaksteinsky M, Weidemman A, Takeda N, Doedens
A, Torres-Collado AX, Iruela-Arispe L, Nizet V, Johnson
RS. Loss of inflammatory cell-derived vascular
endothelial growth factor accelerates fibrosis. Proc Natl Acad Sci USA
2010; 107:4329-4334. ABSTRACT
| PDF | Supplemental |
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Locke JB,
Ostland VE, Vicknair MR, Nizet V, Buchanan JT. Evaluation of
Streptococcus iniae
killed bacterin and live-attenuated vaccines in hybrid
striped bass through injection and bath immersion. Dis Aquat Org
2010; 89:117-123. ABSTRACT
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Nizet
V. Accentuate the (Gram) positive. J Mol Med 2010;
88:93-95. PDF |
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Kurupati P,
Turner CE, Tziona I, Nohadani M, Stamp GW, Zinkernagel AS,
Nizet V, Edwards RJ, Sriskandan S. Chemokine-cleaving
Streptococcus pyogenes
protease SpyCEP is necessary and sufficient for bacterial
dissemination within soft tissues and the respiratory
tract. Mol
Microbiol 2010; 76:1387-1397. ABSTRACT
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Crotty-Alexander LE, Maisey HC, Timmer AM, Rooijakkers SHM, Gallo RL, von Köckritz-Blickwede M, Nizet V. M1T1 group A streptococcal pili promote epithelial colonization but diminish systemic virulence through neutrophil extracellular entrapment. J Mol Med 2010:88:371-881. ABSTRACT | PDF |
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Milani CJ, Aziz RK, Locke JB, Dahesh S, Nizet V, Buchanan JT. The novel polysaccharide deacetylase homologue Pdi contributes to virulence of the aquatic pathogen Streptococcus iniae. Microbiology 2010; 156:543-554. ABSTRACT | PDF |
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Cogen AL,
Yamasaki K, Muto J, Sanchez KM, Crotty-Alexander L, Tanios
J, Lai Y, Kim JE, Nizet V, Gallo RL. Staphylococcus epidermidis
antimicrobial δ-toxin (phenol soluble
modulin-γ) cooperates with host antimicrobial
peptides to kill Group A Streptococcus.
PLoS One 2010; 5:e8557.
ABSTRACT
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Cogen AL, Yamasaki K, Sanchez KM, Dorschner RA, Lai Y, McLeod D, Torpey J, Otto M, Nizet V, Kim JE, Gallo RL. Selective antimicrobial action is provided by phenol soluble modulins derived from Staphylococcus epidermidis, a normal resident of the skin. J Invest Derm 2010; 130:192-200. ABSTRACT | PDF |
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von Köckritz-Blickwede M, Chow OA, Nizet V. Fetal calf serum contains heat-stable nucleases that degrade neutrophil extracellular traps. Blood 2009; 114:5245-5246. PDF |
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Liu GY, Nizet
V. Color me bad: Microbial pigments as virulence
factors. Trends
Microbiol 2009; 17:406-413. ABSTRACT
| PDF | Arsenio
Explains Title |
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Nizet V, Johnson RS. Interdependence of hypoxic and innate immune responses. Nat Rev Immunol 2009; 9:609-617. ABSTRACT | PDF | About the Cover |
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Uchiyama S,
Carlin AF, Khosravi A, Weiman S, Banerjee A, Quach D,
Hightower G, Mitchell TJ, Doran KS, Nizet V. The
surface-anchored NanA protein promotes pneumococcal brain
endothelial cell invasion. J Exp Med 2009;
206:1845-1852. ABSTRACT
| PDF | Supplemental
| Commentary
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Release |
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Lewis A, Desa
N, Hansen E, Knirel Y, Gordon J, Gagneux P, Nizet V, Varki
A. Innovations in host and microbial sialic acid
biosynthesis revealed by phylogenomic prediction of
nonulosonic acid structure. Proc Natl Acad Sci USA 2009;
106:13552-13557. ABSTRACT
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Carlin AF,
Chang YC, Areschoug T, Lindahl G, Hurtado-Ziola N, King CC,
Varki A, Nizet V. Group B Streptococcus
suppression of phagocyte functions by protein-mediated
engagement of human Siglec 5. J Exp Med 2009;
206:1691-1699. ABSTRACT
|
PDF | Supplemental
| Commentary
| Press
Release | About
the
Cover | Podcast |
 |
Weiman S,
Dahesh S, Carlin AF, Varki A, Nizet V, Lewis AL. Genetic and
biochemical modulation of sialic acid O-acetylation on group
B Streptococcus:
phenotypic and functional impact. Glycobiology
2009; 19:1204-1213. ABSTRACT
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PDF |
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Tseng CW,
Kyme P, Low J, Rocha MA, Alsabeh R, Miller LG, Otto M,
Arditi M, Diep BA, Nizet V, Doherty TM, Beenhouwer DO, Liu
GY. Staphylococcus
aureus Panton-Valentine leukocidin contributes to
inflammation and muscle tissue injury. PLoS One 2009;
4:e6837. ABSTRACT
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Jann N,
Schmaler M, Kristian S, Gallo R, Nizet V, Peschel A,
Landmann R. Neutrophil antimicrobial defense against Staphylococcus aureus
mediated by phagolysosomal but not extracellular
trap-associated cathelicidin. J Leukocyte Biol 2009;
86:1159-1169. ABSTRACT
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Hruz P,
Zinkernagel AS, Jenikova G, Botwin G, Hugot JP, Karin M,
Nizet V, Eckmann L. NOD2 contributes to cutaneous defense
against Staphylococcus
aureus through α-toxin-dependent innate immune
activation. Proc
Natl Acad Sci USA 2009; 106:12873-12878. ABSTRACT
|
PDF | Supplemental |
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McGillivray
SM, Ebrahimi CM, Fisher N, Sabet M, Chen Y, Haste NM, Aroian
RV, Gallo RL, Guiney DG, Friedlander AM, Koehler TM, Nizet
V. ClpX contributes to innate defense peptide resistance and
virulence phenotypes of Bacillus
anthracis. J Innate Immun 2009; 1:494-506. ABSTRACT
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von
Köckritz-Blickwede M, Nizet V. Innate immunity turned
inside-out: Antimicrobial defense by phagocyte extracellular
traps. J
Mol Med 2009; 87:775–783. ABSTRACT
| PDF |
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Song Y, Liu
CI, Lin FY, No JH, Hensler ME, Liu YL, Jeng WY, Low J, Liu
GY, Nizet V, Wang AHJ, Oldfield EO. Inhibition of
staphyloxanthin virulence factor biosynthesis in Staphylococcus aureus: In vitro, in vivo, and
crystallographic results. J Med Chem
2009; 52:3869-80.
ABSTRACT
| PDF |
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van Sorge NM,
Quach D, Gurney MA, Sullam PM, Nizet V, Doran KS. The group
B streptococcal Srr-1 glycoprotein mediates penetration of
the blood-brain barrier. J Infect Dis 2009; 199:1479-1487.
ABSTRACT
| PDF |
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Navarini-Meury
AA,
Lang KS, Verschoor A, Recher M, Zinkernagel AS, Nizet V,
Odermatt B, Hengartner H, Zinkernagel RM. Innate
immune-induced depletion of bone marrow neutrophils
aggravates systemic bacterial infections. Proc Natl Acad Sci USA
2009; 106:7107-7112. ABSTRACT
|
PDF | Supplemental
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Commentary |
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Pinheiro da
Silva F, Gallo RL, Nizet V. Differing effects of
exogenous or endogenous cathelicidin on macrophage Toll-like
receptor signaling. Immunol Cell Biol 2009; 87:496-500. ABSTRACT
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Cox KH,
Ruiz-Bustos E, Courtney HS, Dale JB, Pence MA, Nizet V, Aziz
RK, Gerling I, Price SM, Hasty DL. Inactivation of
DltABCD modulates virulence factor expression in Streptococcus pyogenes.
PLoS One
2009: e5366. ABSTRACT
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Lauth X, von
Köckritz-Blickwede M, McNamara CW, Myskowski S, Zinkernagel
AS, Beall B, Ghosh P, Gallo RL, Nizet V. M1 protein
allows group A streptococcal survival in phagocyte
extracellular traps through cathelicidin inhibition. J Innate Immun
2009; 1:202 - 214. ABSTRACT
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PDF |
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Mitchell DA,
Lee SW, Pence MA, Markley AL, Limm JD, Nizet V, Dixon JE.
Structural and functional dissection of the heterocycle
peptide cytolysin streptolysin S. J Biol Chem
2009; 284:13004-12. ABSTRACT
| PDF |
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Pinheiro da
Silva F, Nizet V. Cell death during sepsis:
Integration of disintegration in the inflammatory response
to overwhelming infection. Apoptosis 2009;
14:509-521.
ABSTRACT
|
PDF |
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Carlin AF, Uchiyama S, Chang YC, Lewis AL, Nizet V, Varki A. Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response. Blood 2009; 113:3333-3336. ABSTRACT | PDF |
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Song Y, Lin
FY, Yin F, Hensler M, Rodrigues Poveda CA, Mukkamala D, Cao
R, Morita CT, González-Pacanowska, Nizet V, Oldfield
E. Phosphonosulfonates are potent, selective
inhibitors of dehydrosqualene synthase and staphyloxanthin
biosynthesis in Staphylococcus
aureus. J
Med Chem 2009; 52:976-988. ABSTRACT
|
PDF |
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Sendi P, Johansson L, Dahesh S, van Sorge NM, Darenberg J, Norgren M, Sjölin J, Nizet V, Norrby-Teglund A. Bacterial phenotype variants in group B streptococcal toxic shock syndrome. Emerg Infect Dis 2009; 15:223-232. ABSTRACT | PDF |
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Courtney HS,
Ofek I, Penfound T, Nizet V, Pence MA, Kreikemeyer B,
Podbielbski A, Hasty DL, Dale JB. Relationship between
expression of the family of M proteins and lipoteichoic acid
to hydrophobicity and biofilm formation in Streptococcus pyogenes.
PLoS One
2009; 4:e4166. ABSTRACT
|
PDF |
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Timmer AM,
Timmer JC, Pence MA, Hsu LC, Ghochani M, Frey TG, Karin M,
Salvesen GS, Nizet V. Streptolysin O promotes group A Streptococcus immune
evasion by accelerated macrophage apoptosis. J Biol Chem
2009; 284:862-871. ABSTRACT
|
PDF |
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Nizet V, Esko J. Bacterial and viral infections. Chapter 39 In: Essentials of Glycobiology, 2nd Edition (A Varki, R Cummings, J Esko, H Freeze, G Hart, J Marth, eds.) Cold Spring Harbor Press, Boston, 2009. PubMed | Online Book | PDF |
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Hollands A, Aziz RK, Kansal R, Kotb M, Nizet V, Walker MJ. A naturally occurring mutation in ropB suppresses SpeB expression and reduces M1T1 group A streptococcal systemic virulence. PLoS One 2008 3:e4102. ABSTRACT | PDF |
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Maisey HC,
Doran KS, Nizet V. Recent advances in understanding
the molecular basis of group B streptococcal
virulence. Exp
Rev Mol Med 2008; 10:e27. ABSTRACT
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PDF |
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Nizet V, Rothenberg ME. Mitochondrial missile defense. Nat Med 2008; 9: 910-912. ABSTRACT | PDF |
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Zinkernagel
AC, Timmer AM, Pence MA, Locke JB, Buchanan JT, Turner CE,
Mishalian I, Sriskandan S, Hanski E, Nizet V. IL-8 protease
SpyCEP/ScpC promotes group A streptococcal resistance to
neutrophil killing. Cell Host Microbe 2008;
4:170-178. ABSTRACT
|
PDF | Supplemental
| Press
Release |
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Gallo RL, Nizet V. Innate barriers against skin infection and associated disorders. Drug Disc Today Dis Mech 2008; 5:e145-e152. ABSTRACT | PDF |
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Locke JB, Aziz RK, Vicknair MR, Nizet V, Buchanan JT. Streptococcus iniae M-like protein contributes to virulence in fish and is a target for live-attenuated vaccine development. 2008; 3:e2824. ABSTRACT | PDF |
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Hensler ME, Miyamoto S, Nizet V. Group B streptococcal β-hemolysin/ cytolysin directly impairs cardiomyocyte viability and function. PLoS One 2008 3:e2446. ABSTRACT | PDF |
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Dahesh S, Hensler ME, van Sorge NM, Gertz, RE, Schrag S, Nizet V, Beall BW. Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to β-lactam antibiotics. Antimicrob Agent Chemother 2008 52:2915-2918 ABSTRACT | PDF |
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Timmer AM,
Nizet V. IKKβ/NF-κB and the miscreant
macrophage. J
Exp Med 2008 205:1255-1259. ABSTRACT
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Hsu LC, Ali
R, McGillivray S, Tseng PH, Mariathasan S, Humke E, Eckmann
L, Powell J, Nizet V, Dixit V, Karin M. A NOD2-NALP1 complex
mediates caspase-1 dependent IL-1β secretion in response to
Bacillus anthracis
infection and muramyl dipeptide. Proc Natl Acad Sci USA
2008 105:7803-7808.
ABSTRACT
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PDF | Supplemental |
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Grewal PK,
Uchiyama S, Ditto D, Varki N, Le DT, Nizet V, Marth
JD. The Ashwell receptor mitigates the lethal
coagulopathy of sepsis. Nature Med 2008 14:648-655. ABSTRACT
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PDF | Commentary |
Press
Release |
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Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V, Johnson RS, Haddad GG, Karin M. NF-kB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α. Nature 2008 454:807-811. ABSTRACT | PDF | Supplemental | Press Release |
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Lee SW, Mitchell DA, Markley AL, Hensler ME, Gonzalez D, Wohlrab A, Dorrestein PC, Nizet V, Dixon JE. Discovery of a widely distributed toxin biosynthetic gene cluster. Proc Natl Acad Sci USA 2008 105:5879-5884. ABSTRACT | PDF | Supplemental | Commentary |
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McNamara CW, Zinkernagel AS, Macheboeuf P, Cunningham MW, Nizet V, Ghosh P. Coiled-coil irregularities and instabilities in Group A Streptococcus M1 are required for virulence functions. Science 2008; 319:1405-1408. ABSTRACT | PDF | Supplemental | Press Release |
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Liu C-I, Liu GY, Song Y, Yin F, Hensler ME, Jeng WY, Nizet V*, Wang AH*, Oldfield E*. A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence. Science 2008; 319:391-394. *share senior authorship ABSTRACT | PDF | Supplemental | Press Release | Naked Scientists | NRDD | NEJM | Superbugs Bunny | Angew Chem |
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Buchanan JT, Colvin KM, Vicknair MR, Patel SK, Timmer AM, Nizet V. Strain-associated virulence patterns of Streptococcus iniae in hybrid-striped bass. Vet Microbiol 2008; 131:145-153. ABSTRACT | PDF |
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Nizet V,
Jackson MA. Localized lymphadenitis, lymphadenopathy
and lymphangitis. In: Principles and Practices of
Pediatric Infectious Diseases, 3rd Edition (S Long, LK
Pickering, CG Prober, eds.). Churchill Livingstone, New
York, p. 463-467, 2008. Preview |
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Kraus D,
Herbert S, Kristian S, Nizet V, Götz F, Peschel A. The GraRS
regulatory system controls in vivo susceptibility of Staphylococcus aureus
to antimicrobial host defenses. BMC Microbiol
2008; 8:85. ABSTRACT
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Peyssonnaux C, Boutin A, Zinkernagel A, Datta V, Nizet V, Johnson RS. Critical role of HIF-1α in keratinocyte defense against bacterial infection. J Invest Dermatol 2008; 128:1964-1968. ABSTRACT | PDF |
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Maisey HC, Hensler ME, Quach D, Liu GY, Gallo RL, Nizet V, Doran KS. A group B streptococcal pilus protein promotes phagocyte resistance and systemic virulence. FASEB J 2008 22:1715-1724. ABSTRACT | PDF |
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Zinkernagel AC, Peyssonnaux C, Johnson RS, Nizet V. Pharmacological augmentation of HIF-1α with mimosine boosts the bactericidal capacity of phagocytes. J Infect Dis 2008; 197:214-217. ABSTRACT | PDF |
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Park B, Nizet V, Liu GY. Role of Staphylococcus aureus catalase in niche competition against Streptococcus pneumoniae. J Bacteriol 2008; 190:2275-2278. ABSTRACT | PDF |
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Gillen CM, Courtney HS, Schulze K, Rohde M, Wilson MR, Timmer AM, Guzman CA, Nizet V, Chhatwal GS, and Walker MJ. Opacity factor activity and epithelial cell binding by the serum opacity factor protein of Streptococcus pyogenes are functionally discrete. J Biol Chem 2008; 283:6359-6366. ABSTRACT | PDF |
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Cogen AL, Nizet V, Gallo RL. Skin microbiota: A source of disease or defence? Br J Dermatol 2008 158:442-455. ABSTRACT | PDF |
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Peyssonnaux C, Nizet V, Johnson R. Role of the hypoxia-inducible factors in iron metabolism. Cell Cycle 2008 7:28-32. ABSTRACT | PDF |
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Meluzzi D, Zheng W, Hensler M, Nizet V, Dorrestein PC. Top-down mass spectrometry on low-resolution instruments: characterization of phosphopantheteinylated carrier domains in polyketide and non-ribosomal biosynthetic pathways. Bioorg Med Chem Lett 2008 18:3107-3111. ABSTRACT | PDF |
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Hensler ME, Quach D, Hsieh C.-J., Doran KS, Nizet V. CAMP factor is not essential for systemic virulence of Group B Streptococcus. Microb Pathog 2008 44:84-88 ABSTRACT | PDF |
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Zinkernagel
AS, Johnson RS, Nizet V. Hypoxia inducible factor (HIF)
function in innate immunity and infection. J Mol Med
2007 85:1139-1146. ABSTRACT
| PDF |
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Cole JN,
Aquilina JA, Hains PJ, Henningham A, Sriprakash KS, Caparon
MG, Pancholi V, Nizet V, Kotb M, Cordwell SJ, Djordjevic SP,
Walker MJ. Role of group A Streptococcus HrtA in the maturation of
SpeB protease. Proteomics 2007
7:4488-4498. ABSTRACT
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PDF |
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Walker MJ,
Hollands A, Sanderson-Smith M, Cole JN, Kirk JK, Henningham
A, McArthur JD, Dinkla K, Aziz RK, Kansal RG, Simpson
AJ, Buchanan JT, Chhatwal GS, Kotb M, Nizet V. DNase Sda1
provides selection pressure for a switch to invasive group A
streptococcal infection. Nat Med 2007 13:981-985. ABSTRACT
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PDF | Supplemental | News & Views
| Press
Release |
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Lewis AL, Cao H, Patel SK, Diaz S, Ryan W, Carlin AF, Thon V, Lewis WG, Varki A, Chen X, Nizet V. NeuA O-acetylesterase activity modulates O-acetylation of capsular polysaccharides in group B Streptococcus. J Biol Chem 2007 282:27562-27571 ABSTRACT | PDF |
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Bayele HK,
Peyssonnaux C, Giatromanolaki A, Arrais-Silva WW, Mohamed
HS, Collins H, Giorgio S, Koukourakis M, Johnson RS,
Blackwell JM, Nizet V, Sria SK. HIF-1α regulates
heritable variation and allele expression phenotypes of the
macrophage immune response gene SLC11A1 from a Z DNA forming
microsatellite. Blood 2007 110:3039-3048. ABSTRACT
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PDF |
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Nizet
V. Understanding how leading bacterial pathogens
subvert innate immunity to reveal novel therapeutic
targets. J
Allergy Clin Immunol 2007 120:13-22. ABSTRACT
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PDF |
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Peyssonnaux
C, Zinkernagel AS, Scheupbach RA, Rankin E, Vaulont S, Haase
VH, Nizet V*, Johnson RS*. Regulation of iron
homeostasis by the hypoxia inducible transcription factors
(HIF)
J Clin Invest
2007 117:1926-1932. *share
senior authorship ABSTRACT
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PDF | Press
Release |
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Peyssonnaux C, Cejudo-Martin P, Doedens A, Zinkernagel AS, Johnson RS, Nizet V. Cutting edge: Essential role of hypoxia inducible factor-1α in development of LPS-induced sepsis. J Immunol 2007 178:7516–7519. ABSTRACT | PDF |
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Locke JB, Colvin KM, Varki N, Vicknair MR, Nizet V, Buchanan JT. The Streptococcus iniae beta-hemolysin streptolysin S is a virulence factor in fish infection. Dis Aquat Organ 2007 76:17-26. ABSTRACT | PDF |
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Zinkernagel
AS, Nizet V. Staphylococcus
aureus: A blemish on skin immunity. Cell Host &
Microbe 2007 1:161-162. ABSTRACT
| PDF |
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Carlin AF, Lewis AL, Varki A, Nizet V. Group B streptococcal capsular sialic acid interacts with Siglecs (immunoglobulin-like lectins) on human leukocytes. J Bacteriol 2007 189:1231-1237. ABSTRACT | PDF |
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Kwinn LA, Khosravi A, Aziz RK, Timmer AM, Doran KS, Kotb M, Nizet V. Genetic characterization and virulence role of the RALP3/LSA locus upstream of the streptolysin S operon in invasive M1T1 group A Streptococcus. J Bacteriol 2007 189:1322-1329. ABSTRACT | PDF |
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Kristian SA,
Timmer AM, Liu GY, Lauth X, Sal-Man N, Rosenfeld Y, Shai Y,
Gallo RL, Nizet V. Impairment of innate immune killing
mechanisms by bacteriostatic antibiotics. FASEB J 2007
21:1107-1116. ABSTRACT
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PDF |
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Maisey HC, Hensler MC, Nizet V, Doran KS. Group B streptococcal pili proteins contribute to adherence and invasion of brain microvascular endothelial cells. J Bacteriol 2007 189:1464-1467. ABSTRACT | PDF |
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Kwinn
LA, Nizet V. How group A Streptococcus circumvents host phagocyte
defenses. Future
Microbiol 2007 2:75-84. ABSTRACT
| PDF |
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Locke JB, Colvin KM, Datta AK, Patel SK, Naidu NN, Neely MN, Nizet V, Buchanan JT. Streptococcus iniae capsule impairs phagocytic clearance and contributes to virulence in fish. J Bacteriol 2007 189:1279-1287. ABSTRACT | PDF |
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Timmer AM, Kristian SA, Datta V, Jeng A, Gillen CM, Walker MJ, Beall B, Nizet V. Serum opacity factor promotes group A streptococcal epithelial cell invasion and virulence. Mol Microbiol 2006 62:15-25. ABSTRACT | PDF |
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Buchanan JT, Simpson AJ, Aziz RK, Liu GY, Kristian SA, Kotb M, Feramisco J, Nizet V. DNase expression allows the pathogen group A Streptococcus to escape killing in neutrophil extracellular traps. Curr Biol 2006 16:396-400. ABSTRACT | PDF | Press Release |
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Lewis ML, Hensler ME, Varki A, Nizet V. The group B streptococcal sialic acid O-acetyltransferase is encoded by neuD, a conserved component of bacterial sialic acid biosynthetic gene clusters. J Biol Chem 2006 281:11186-11192. ABSTRACT | PDF |
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Chen Y,
Corriden R, Inoie Y, Yip L, Hashiguchi N, Zinkernagel
A, Nizet V, Insel PA, Junger WG. ATP release
guides neutrophil chemotaxis via P2Y2 and A3
receptors. Science
2006 314:1792-1795.
ABSTRACT
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PDF | Supplemental
| Press
Release |
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Dehority W, Uchiyama S, Khosravi A, Nizet V. Brain abscess caused by Streptococcus pyogenes in a previously healthy child. J Clin Microbiol 2006 44:4613-4615. ABSTRACT | PDF |
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Hamilton A,
Popham DL, Carl DJ, Lauth X, Nizet V, Jones AL.
Penicillin-binding protein 1a promotes resistance of group B
streptococcus to antimicrobial peptides. Infect Immun
2006 74:6179-6187. ABSTRACT
| PDF |
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Hidalgo-Grass C, Mishalian I, Dan-Goor M, Belotserkovsky I, Eran Y, Nizet V, Peled A Hanski E. A streptococcal protease that locally degrades CXC chemokines subverting innate immune responses in the skin. EMBO J 2006 25:4628-4637. ABSTRACT | PDF |
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Hensler ME, Bernstein G, Nizet V, Nefzi A. Pyrrolidine bis-cyclic guanidines with antimicrobial activity against drug resistant Gram-positive pathogens identified from a mixture-based combinatorial library. Bioorg Med Chem Lett 2006 16:5073-5079. ABSTRACT | PDF |
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Cole JN,
McArthur JD, McKay FC, Sanderson-Smith ML, Cork AJ, Ranson
M, Rohde M, Itzek A, Sun H, Ginsburg D, Kotb M, Nizet V,
Chhatwal GS, Walker MJ. Trigger for group A
streptococcal M1T1 invasive infection. FASEB J 2006
20:1745-1747. ABSTRACT
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PDF |
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Karin M, Lawrence T, Nizet V. Innate immunity gone awry: Linking microbial infections to chronic inflammatory diseases and cancer. Cell 2006 124:823-8235. ABSTRACT | PDF |
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Peyssonnaux
C, Zinkernagel AS, Datta V, Lauth X, Johnson RS, Nizet
V. TLR4-dependent hepcidin expression by myeloid cells
in response to bacterial pathogens. Blood 2006
107:3727-3732. ABSTRACT
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PDF |
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Liu GY, Nizet
V. The group B streptococcal
ß-hemolysin/cytolysin. In: The Comprehensive
Sourcebook of Bacterial Protein Toxins, 3rd Edition.
Eds: J Alouf, M Popoff. Elsevier. 2006 PDF |
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Nizet
V. Antimicrobial peptide resistance mechanisms of
human bacterial pathogens. Curr Issues Mol Biol
2006 8:11-26. ABSTRACT
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PDF |
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Kristian SA,
Datta V, Weidenmaier C, Kansal R, Fedtke I, Peschel A, Gallo
RL, Nizet V. DltABCD mediated D-alanylation of
teichoic acids in group A Streptococcus confers innate
immune resistance. In Streptococci - New Insights Into
an Old Enemy. International Congress Series 129. Elsevier.
Amsterdam, p. 254-256. 2006. PDF |
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Dorschner RA,
Lopez-Garcia B, Peschel A, Kraus D, Morikawa K, Nizet V,
Gallo RL. The mammalian ionic environment dictates
microbial susceptibility to antimicrobial defense
peptides. FASEB
J 2006 20:35-42. ABSTRACT
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PDF |
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Timmer AM,
Datta V, Kristian S, Jeng A, Beall B, Nizet V. The
contribution of serum opacity factor to group A
streptococcal epithelial cell invasion. In Streptococci -
New Insights Into an Old Enemy. International Congress
Series 129. Elsevier. Amsterdam, p. 246-249. 2006. PDF |
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Nizet V, Rubens CE. Pathogenic mechanisms and virulence factors of group B streptococci. In: Gram-positive pathogens, 2nd Edition. Eds: VA Fischetti, RP Novick, JJ Ferretti, DA Portnoy, JI Rood. ASM Press 2006; pp. 152-168. |
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Maisey HC,
Hensler ME, Khosravi A, Liu GY, Nizet V, Doran KS. A
single streptococcal gene can confer innate immune
resistance and virulence to a nonpathogenic bacterium. In
Streptococci - New Insights Into an Old Enemy. International
Congress Series 129. Elsevier. Amsterdam, p. 223-226.
2006. PDF |
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Buchanan JT, Stannard JA, Lauth X, Ostland VE, Powell HC, Westerman ME, Nizet V. Streptococcus iniae phosphoglucomutase is a virulence factor and target for vaccine development. Infect Immun 2005 73:6935-6944. ABSTRACT | PDF |
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Kristian SA,
Datta V, Weidenmaier C, Kansal R, Fedtke I, Peschel A, Gallo
RL, Nizet V. D-alanylation of teichoic acids promotes
group A Streptococcus
antimicrobial peptide resistance, neutrophil survival and
epithelial cell invasion. J Bacteriol
2005 187:6719-6725. ABSTRACT
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PDF |
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Doran KS, Engelson EJ, Khosravi A, Maisey HC, Fedtke I, Equils O, Michelsen KS, Arditi M, Peschel A, Nizet V. Group B Streptococcus blood-brain barrier invasion depends upon proper cell surface anchoring of lipoteichoic acid. J Clin Invest 2005 115:2499-2507. ABSTRACT | PDF | JCI Commentary: Abstract | PDF | Press Release |
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Liu GY, Essex
A, Buchanan JT, Datta V, Hoffman HA, Bastian J, Fierer J,
Nizet V. Staphylococcus
aureus golden
pigment impairs neutrophil killing and promotes virulence
through its antioxidant activity. J Exp Med
2005 202: 209-215. ABSTRACT
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PDF | About
the
Cover | Press
Release | ASM
News |
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Peyssonnaux
C, Datta V, Cramer T, Doedens A, Theodorakis E, Gallo R,
Hurtado-Ziola N, Nizet V*, Johnson RS*. HIF-1alpha
expression regulates the bactericidal capacity of
phagocytes. J
Clin Invest 2005 115:1806-1815. *share senior authorship ABSTRACT
|
PDF | JCI
Commentary: Abstract
PDF | Press
Release | Audio Clip |
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Datta V,
Myskowski SM, Kwinn LA, Chiem DN, Varki N, Kansal R, Kotb M,
Nizet V. Mutational analysis of the group A
streptococcal operon encoding streptolysin S and its
virulence role in invasive infection. Mol Microbiol
2005 56:681-95. ABSTRACT
| PDF |
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Lawrence T,
Bebien M, Liu GY, Nizet V, Karin M. IKKalpha limits
macrophage NF-kB activation and contributes to the
resolution of inflammation. Nature
2005 434:1138-1143. ABSTRACT
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PDF | Press
Release |
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Edwards MS, Nizet V, Baker CJ. Group B streptococcal infections. In: Infectious Diseases of the Fetus and Newborn Infant, 6th Edition. Eds: J Remington, J Klein, CJ Baker, CB Wilson. Elselvier Saunders, Philadelphia. pp. 404-464. 2006. |
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Braff MH, Zaiou M, Fierer J, Nizet V, Gallo R. Keratinocyte production of cathelicidin provides direct antimicrobial activity against bacterial skin pathogens. Infect Immun 2005 73:6771-6781. ABSTRACT | PDF |
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Hensler ME,
Liu GY, Sobczak S, Benirshcke K, Nizet V, Heldt GP.
Virulence role of the group B streptococcal
ß-hemolysin/cytolysin in a neonatal rabbit model of early
onset pulmonary infection. J Infect Dis 2005
191:1287-91. ABSTRACT
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PDF |
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Georgel P, Crozat K, Lauth X, Makrantonaki E, Seltmann H, Sovath S, Heobe K, Du X, Rutschmann S, Jiang Z, Bigby T, Nizet V, Zouboulis CC, Beutler B. A TLR2-responsive lipid effector pathway protects mammals against Gram-positive bacterial skin infections. Infect Immun 2005 73:4512-4521. ABSTRACT | PDF |
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Braff MH, Bardan A, Nizet V, Gallo RL. Cutaneous defense mechanisms by antimicrobial peptides. J Invest Dermatol 2005 125:9-13. ABSTRACT | PDF |
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Lauth X, Babon J, Stannard JA, Singh S, Nizet V, Carlberg JM, Ostland VE, Pennington MW, Norton RS, Westerman ME. Bass hepcidin: synthesis, solution structure, antimicrobial activities and synergism, and in vivo hepatic response to bacterial infections. J Biol Chem 2005; 280:9272-9282. ABSTRACT | PDF |
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Nizet V. Antimicrobial peptide resistance in human bacterial pathogens. In: Antimicrobial Peptides in Human Health and Disease. Ed: RL Gallo. Horizon Press, Norwich UK pp. 277-304. 2005. ABSTRACT |
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