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Accepted Manuscripts in Press

Nature Microbiology Valderrama JA, Riestra A, Gao NJ, LaRock CN, Gupta N, Ali SR, Hoffman HM, Ghosh P, Nizet V.  Group A streptococcal M protein activates the NLRP3 inflammasome.  Nat Microbiol 2017.
Nature Communications Sun J, Lei L, Tsai CM, Wang Y, Shi Y, Ouyang M, Lu S, Seong J, Kim T, Wang P, Huang M, Xu X, Nizet V, Chien S, Wang Y. Engineered proteins with sensing and activating modules for automated reprogramming of cellular functions.  Nat Commun 2017
Journal of
                Antibiotics Reynolds KA, Dahesh S, Nizet V, Moore BS.  Isolation and structure elucidation of taromycin B from the activated taromycin biosynthetic gene cluster.  J Antibiot 2017
Immunology & Cell BIology Patras KA, Coady A, Olson J, Ali SR, RamachandraRao S, Varki A, Nizet V.  Tamm-Horsfall glycoprotein engages human Siglec-9 to modulate neutrophil activation in the urinary tract.  Immunol Cell Biol 2017


Submitted Manuscripts in Peer Review



Guichard A, Jain P, Moayeri M, Schwarz R, Chin S, Zhu L, Cruz-Moreno B, Liu JZ, Aguilar B, Hollands A, Leppla SH, Nizet V, Bier E.  Anthrax edema toxin disrupts distinct dteps in Rab11-dependent junctional transport.

Munguia J, Lin L, Olson J, Nonejuie P, Gallo RL, Adams MD, Kirkup BC, Pogliano J, Zurawski DV, Nizet V. Outer membrane lipid modifying protein VacJ contributes to antimicrobial peptide resistance and virulence of multidrug-resistant Acinetobacter baumannii.

Lawrence SM, Corriden R, Nizet V.  The lifecycle of a neutrophil, Part 1: Ontogeny, granulopoiesis and homeostasis .

Lawrence SM, Corriden R, Nizet V.  The lifecycle of a neutrophil, Part 2: Effector functions, cell death regulation and roles in human disease.

Pence MA, Malone C, van Sorge NM, Horswill AR, Nizet V.  The metalloprotease aureolysin is not essential for cathelicidin resistance or virulence of methicillin-resistant Staphylococcus aureus

Kumaraswamy M, Ashlock B, Nizet V, Crotty Alexander L.  Flu Gone Bad:  Asthma, influenza and secondary bacterial pneumonia precipitating diabetic ketoacidosis in a morbidly obese diabetic male.

Ugolini F, Andreoni F, Keller N, Neff A, Nizet V, Hollands A, Marques-Maggio E, Zinkernagel A, Schuepbach R.  Attenuation of streptokinase-mediated virulence in Streptococcus (SDSE) necrotizing fasciitis by immunoglobulin.

Mesci P, Macia A, LaRock CN, Tejwani L, Fernandes IR, Suarez NA, Nizet V, Beltrão-Braga CB, Muotri AR. Differential signature of the Brazilian Zika virus infection in human developing human macrophages.

van den Broek M, Claes I, Nizet V, Lebeer S.  Antimicrobial activity of lactobacilli and lactic acid against key otitis media pathogens.

Sun J, Lei L, Tsai CM, Wang Y, Ouyang M, Lu S, Seong J, Kim T, Huang M, Xu X, Nizet V, Chien S, Wang Y. Engineered proteins with sensing and actuating modules for automated reprogramming of cellular functions.

Yang WH, Heithoff DM, Aziz PV, Sperandio M, Nizet V, Mahan MJ, Marth JD.  Recurrent Salmonella infection progressively disables a homeostatic mechanism of host protection.

Caffrey AR, Timbrook TT, Ali SR, Nizet V, Sakoulas G.  Proton pump inhibitors do not influence clinical outcomes in patients with Staphylococcus aureus bacteremia.

Munguia J, LaRock D, Tsunemoto H, Olson J, Cornax I, Pogliano P, Nizet V. The Mla pathway is critical for Pseudomonas aeruginosa resistance to outer membrane permeabilization and host innate immune clearance.

Monogue M, Sakoulas G, Nizet V, Nicolau D.  Humanized exposures of a β-lactam-β-lactamase inhibitor, tazobactam, versus non-β-lactam-β-lactamase inhibitor, avibactam, with or without colistin, against Acinetobacter baumannii in murine thigh and lung infection models.

Choe D,  Szubin R,  Dahesh S,  Cho; S, Nizet V, Palsson BO, Cho BK. Genome-scale analysis of community-acquired methicillin-resistant Staphylococcus aureus USA300 reveals a tradeoff between pathogenesis mechanisms and antibiotic resistance.

Askarian F, Lapek JD, Tsai CM, Kumaraswamy M, Kousha A, Valderrama JA, Ludviksen JA, Cavanagh PJ, Uchiyama S, Mollnes TE, Gonzalez DJ, Wai SN, Nizet V, Johannessen M.  Staphylococcus aureus membrane-derived vesicles confer immune resistance and proinflammatory properties and serve as a vaccination platform.

Sakoulas G, Kumaraswamy M, Kousha A, Nizet V.  Salmonella enteritidis meningitis in an immunocompetent adult: an ppportunity to examine the interaction of antimicrobial therapy with a critical host innate defense factor.

Schooley R, Biswas B, Gill J, Hernandez-Morales A,  Lancaster J,  Lessor L, Barr J, Reed S, Rohwer F, Benler S, Segall A,  Taplitz R, Smith D, Kerr K, Kumaraswamy M, Nizet V, Lin L, McCauley M, Strathdee S, Benson C, Leroux B, Pope R, Picel A,  Mateczun A, Cilwa K, Regeimbal J, Estrella L, Wolfe D, Henry M, Quinones J, Salka S, Bishop-Lilly K, Young R, Hamilton T. Development and use of personalized .bacteriophage-based therapeutic cocktails to treat a patient with a disseminated resistant Acinetobacter baumannii infection.

Valderrama JA, Nizet V. Group A Streptococcus encounters with host macrophages.

Alisson-Silva F, Liu J, Diaz S, Deng L, Gareau M, Chen X, Nizet V, Varki N, Barrett K, Varki A. Human evolutionary loss of epithelial Neu5Gc expression and the species-specific susceptibility to cholera.

Liu JZ, Ali SR, Bier E, Nizet V.  Innate immune interactions between Bacillus anthracis and host neutrophils.

Corriden R, Liu R, Shin S, Sinha R, Pogliano J, Pogliano K, Griffin J, Nizet V, Gupta N.  MDSCH79797 Improves Outcomes in Murine E. coli Pneumonia by Augmentation of Neutrophil Antibacterial Activity and Direct Antibacterial Action

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